iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054507

UUCD1 version

UUC-LoA-00033

Ensembl Protein ID

ENSLAFP00000000769.3

UniProt Accession

G3SML6; G3SML6_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000000918.3	ENSLAFT00000000919.3	ENSLAFP00000000769.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.50e-75	252.4	527	854

Active Site

Position(s)	Description	Evidence
823	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 527  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 615
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      ++++++d++f ++ +    l++++++eL+pgG+ i V +e+++++
   Q: 616  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVME-----GMDKETFDFKFGKELTFttvLSDQQVVELIPGGAGIVVGYEDRSRF 699
           **************************************.....556677788887443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++ v ++rl+e  keq++a+++G+ +v+p+ +l+l+t++ele  +cG++e++v +l+k t++++ ++++++ +q+Fwe+l++f++e+r+
   Q: 700  IQMVQKARLEE-SKEQLAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVAALRKLTRFED-FEKSDKRVQYFWEALNNFTNEDRS 786
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeY.sskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y ss ++++ekL+yA  ++ +++
   Q: 787  RFLRFVTGRSRLPA--------RIYIYPDklgYETTDALPESSTCSSTLFLPHYaSSAKVCEEKLRYAAYNCVAID 854
           *************5........6667777799999*******************5567899*********998776 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAGPSPGATL ESPRQLLGRV RFLAEAARNL RAGRPLPEAL AFVPREVLYK LYKDPAGPSR 60
VLLPVWEAEG LGLRVGAAGP APSTGSGPLR AARDSIELRR GACVRTTGEE LCNGYGLWVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGGTC CAAGCCCGGG CGCGACGCTG GAGTCCCCCA GGCAGCTGTT GGGCCGCGTG 60
CGCTTCCTGG CGGAGGCAGC GCGAAACCTC CGCGCGGGGC GGCCACTGCC GGAGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	96.64	0.00e+00	1654.00
IUUC-Apl-003715	Anas platyrhynchos	84.73	0.00e+00	1305.00
IUUC-Aca-004377	Anolis carolinensis	78.36	0.00e+00	1371.00
IUUC-Ame-011918	Astyanax mexicanus	64.34	0.00e+00	1119.00
IUUC-Bta-012736	Bos taurus	97.10	0.00e+00	1674.00
IUUC-Cja-019926	Callithrix jacchus	96.98	0.00e+00	1657.00
IUUC-Cfa-020753	Canis familiaris	97.23	0.00e+00	1158.00
IUUC-Cpo-021415	Cavia porcellus	96.40	0.00e+00	1652.00
IUUC-Csa-023096	Chlorocebus sabaeus	97.10	0.00e+00	1659.00
IUUC-Dre-028746	Danio rerio	69.32	0.00e+00	1194.00
IUUC-Dno-029293	Dasypus novemcinctus	96.62	0.00e+00	1059.00
IUUC-Dor-031113	Dipodomys ordii	97.21	0.00e+00	1225.00
IUUC-Ete-032601	Echinops telfairi	88.81	0.00e+00	1409.00
IUUC-Eca-034198	Equus caballus	94.78	0.00e+00	1623.00
IUUC-Eeu-034708	Erinaceus europaeus	95.99	0.00e+00	886.00
IUUC-Fca-035478	Felis catus	97.46	0.00e+00	1639.00
IUUC-Fal-037366	Ficedula albicollis	76.55	0.00e+00	1330.00
IUUC-Gmo-039020	Gadus morhua	75.19	0.00e+00	1041.00
IUUC-Gga-040332	Gallus gallus	79.27	0.00e+00	1391.00
IUUC-Gac-042336	Gasterosteus aculeatus	69.66	0.00e+00	1237.00
IUUC-Ggo-045382	Gorilla gorilla	97.33	0.00e+00	1663.00
IUUC-Hsa-046562	Homo sapiens	97.33	0.00e+00	1663.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	96.98	0.00e+00	1665.00
IUUC-Lch-049606	Latimeria chalumnae	64.80	0.00e+00	834.00
IUUC-Loc-052448	Lepisosteus oculatus	62.54	0.00e+00	1073.00
IUUC-Mcc-055690	Macaca mulatta	97.10	0.00e+00	1662.00
IUUC-Meu-055970	Macropus eugenii	84.57	0.00e+00	1428.00
IUUC-Mga-059654	Meleagris gallopavo	84.93	0.00e+00	1290.00
IUUC-Mmr-061069	Microcebus murinus	97.33	0.00e+00	1664.00
IUUC-Mdo-062547	Monodelphis domestica	90.80	0.00e+00	778.00
IUUC-Mmu-063096	Mus musculus	96.52	0.00e+00	1655.00
IUUC-Mpu-065846	Mustela putorius furo	96.75	0.00e+00	1667.00
IUUC-Mlu-067992	Myotis lucifugus	96.18	0.00e+00	1556.00
IUUC-Nle-069565	Nomascus leucogenys	97.28	0.00e+00	1560.00
IUUC-Opr-070853	Ochotona princeps	82.84	0.00e+00	999.00
IUUC-Ont-071628	Oreochromis niloticus	69.16	0.00e+00	1204.00
IUUC-Ocu-074094	Oryctolagus cuniculus	97.10	0.00e+00	1664.00
IUUC-Ola-087384	Oryzias latipes	69.18	0.00e+00	1250.00
IUUC-Oga-088224	Otolemur garnettii	96.75	0.00e+00	1664.00
IUUC-Oar-090043	Ovis aries	91.18	0.00e+00	1556.00
IUUC-Ptr-090852	Pan troglodytes	97.10	0.00e+00	1655.00
IUUC-Pan-092787	Papio anubis	97.10	0.00e+00	1661.00
IUUC-Psi-092986	Pelodiscus sinensis	72.46	0.00e+00	969.00
IUUC-Pma-094416	Petromyzon marinus	39.62	2.00e-172	599.00
IUUC-Pfo-096720	Poecilia formosa	69.24	0.00e+00	1244.00
IUUC-Pab-098325	Pongo abelii	97.02	0.00e+00	1289.00
IUUC-Pca-100885	Procavia capensis	83.03	0.00e+00	1191.00
IUUC-Pva-102829	Pteropus vampyrus	85.43	0.00e+00	1054.00
IUUC-Rno-104882	Rattus norvegicus	96.75	0.00e+00	1659.00
IUUC-Sha-106811	Sarcophilus harrisii	90.57	2.00e-115	409.00
IUUC-Sar-113020	Sorex araneus	82.70	0.00e+00	702.00
IUUC-Ssc-115436	Sus scrofa	97.78	7.00e-159	553.00
IUUC-Tgu-117042	Taeniopygia guttata	78.97	0.00e+00	1378.00
IUUC-Tru-118419	Takifugu rubripes	67.01	0.00e+00	1161.00
IUUC-Tsy-118829	Tarsius syrichta	97.73	0.00e+00	991.00
IUUC-Tni-120410	Tetraodon nigroviridis	56.13	0.00e+00	915.00
IUUC-Tbe-128113	Tupaia belangeri	97.13	0.00e+00	768.00
IUUC-Ttr-128167	Tursiops truncatus	92.69	0.00e+00	1595.00
IUUC-Xtr-132910	Xenopus tropicalis	64.58	0.00e+00	1078.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence