iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046952

UUCD1 version

UUC-HoS-00100

Ensembl Protein ID

ENSP00000247668.2

UniProt Accession

Q12933; A8K107; B4DPJ7; Q7Z337; Q96NT2; TRAF2_HUMAN

Genbank Protein ID

AAA87706.1; BAB70792.1; BAF82411.1; BAG60609.1; CAD98040.1; AAT27320.1; CAI12703.1; CAI12703.1; CAI15106.1; CAI15106.1; EAW88299.1; AAH32410.1; AAH33810.1; AAH43492.1; AAH64662.1

Protein Name

TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

Genbank Nucleotide ID

U12597; AK054686; AK289722; AK298370; BX538160; AY623660; AL355987; AL449425; AL449425; AL355987; CH471090; BC032410; BC033810; BC043492; BC064662

Gene Name

TRAF2; TRAP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000127191.17	ENST00000247668.6	ENSP00000247668.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17878343; 12591926; 20047764; 18671942; 19854138; 18997792; 16936264

Organism

Homo sapiens

Functional Description
(View)

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Protein Sequence
(Fasta)

MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS 60
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGACTGC AGAGTGAGAG TGAAACCAGC TTCCCTCGGA GGCTGCAGCA CAGGGCTGAC 60
ATGCAAACGT CTGAAAAAGA GGCAAGCTCT CGGTGTGAGC AAGTGGACTG CGGCTATTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0005174--F:CD40 receptor binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0004871--F:signal transducer activity
GO:0046625--F:sphingolipid binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:0071550--P:death-inducing signaling complex assembly
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:1901215--P:negative regulation of neuron death
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0050870--P:positive regulation of T cell activation
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0006461--P:protein complex assembly
GO:0016579--P:protein deubiquitination
GO:0051291--P:protein heterooligomerization
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051023--P:regulation of immunoglobulin secretion
GO:0060544--P:regulation of necroptotic process
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress
GO:0007165--P:signal transduction
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG

hsa:7186

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000744	Aegilops tauschii	27.12	8.00e-06	46.60
IUUC-Aml-002344	Ailuropoda melanoleuca	85.85	0.00e+00	904.00
IUUC-Apl-004202	Anas platyrhynchos	74.48	0.00e+00	832.00
IUUC-Aca-005029	Anolis carolinensis	58.47	7.00e-148	516.00
IUUC-Ame-011841	Astyanax mexicanus	55.59	0.00e+00	642.00
IUUC-Bta-013180	Bos taurus	85.94	0.00e+00	891.00
IUUC-Cja-019813	Callithrix jacchus	97.01	0.00e+00	1014.00
IUUC-Cfa-021205	Canis familiaris	90.42	0.00e+00	920.00
IUUC-Cpo-021346	Cavia porcellus	89.42	0.00e+00	926.00
IUUC-Csa-023809	Chlorocebus sabaeus	97.31	0.00e+00	902.00
IUUC-Dre-027669	Danio rerio	58.73	2.00e-178	619.00
IUUC-Dno-029458	Dasypus novemcinctus	84.14	0.00e+00	894.00
IUUC-Dor-030338	Dipodomys ordii	86.83	0.00e+00	835.00
IUUC-Eca-034401	Equus caballus	90.10	0.00e+00	945.00
IUUC-Eeu-034668	Erinaceus europaeus	70.36	2.00e-107	382.00
IUUC-Fca-036057	Felis catus	86.62	0.00e+00	930.00
IUUC-Fal-037560	Ficedula albicollis	72.83	0.00e+00	738.00
IUUC-Gmo-038964	Gadus morhua	62.82	0.00e+00	667.00
IUUC-Gga-040425	Gallus gallus	75.33	0.00e+00	829.00
IUUC-Gac-041908	Gasterosteus aculeatus	64.09	0.00e+00	684.00
IUUC-Ggo-044606	Gorilla gorilla	91.22	0.00e+00	936.00
IUUC-Hvu-047095	Hordeum vulgare	26.27	3.00e-05	44.70
IUUC-Itr-049016	Ictidomys tridecemlineatus	76.25	0.00e+00	780.00
IUUC-Lch-049571	Latimeria chalumnae	59.76	0.00e+00	712.00
IUUC-Loc-051973	Lepisosteus oculatus	62.98	0.00e+00	635.00
IUUC-Laf-053815	Loxodonta africana	83.89	0.00e+00	854.00
IUUC-Mcc-054888	Macaca mulatta	98.40	0.00e+00	1022.00
IUUC-Meu-056547	Macropus eugenii	74.43	0.00e+00	671.00
IUUC-Mga-059819	Meleagris gallopavo	75.25	0.00e+00	786.00
IUUC-Mdo-062570	Monodelphis domestica	82.87	0.00e+00	858.00
IUUC-Mmu-063133	Mus musculus	86.83	0.00e+00	873.00
IUUC-Mac-064547	Musa acuminata	32.65	5.00e-06	47.40
IUUC-Mpu-065802	Mustela putorius furo	87.50	0.00e+00	925.00
IUUC-Nle-070155	Nomascus leucogenys	98.80	0.00e+00	1028.00
IUUC-Opr-070856	Ochotona princeps	85.96	8.00e-114	404.00
IUUC-Ont-071930	Oreochromis niloticus	64.10	0.00e+00	711.00
IUUC-Ola-087397	Oryzias latipes	61.08	0.00e+00	688.00
IUUC-Oga-088109	Otolemur garnettii	94.41	0.00e+00	992.00
IUUC-Oar-090310	Ovis aries	76.49	0.00e+00	793.00
IUUC-Ptr-090643	Pan troglodytes	99.40	0.00e+00	1031.00
IUUC-Pan-091933	Papio anubis	98.20	0.00e+00	1020.00
IUUC-Psi-093681	Pelodiscus sinensis	73.53	0.00e+00	786.00
IUUC-Pfo-096148	Poecilia formosa	60.52	0.00e+00	694.00
IUUC-Pab-098631	Pongo abelii	99.20	0.00e+00	1032.00
IUUC-Pca-100582	Procavia capensis	67.44	7.00e-90	324.00
IUUC-Pva-102396	Pteropus vampyrus	75.05	0.00e+00	744.00
IUUC-Rno-106120	Rattus norvegicus	86.63	0.00e+00	860.00
IUUC-Sha-106493	Sarcophilus harrisii	82.87	0.00e+00	882.00
IUUC-Sit-110103	Setaria italica	26.27	6.00e-05	43.90
IUUC-Sar-113570	Sorex araneus	93.37	7.00e-100	357.00
IUUC-Ssc-115843	Sus scrofa	85.19	0.00e+00	918.00
IUUC-Tgu-117144	Taeniopygia guttata	70.28	0.00e+00	706.00
IUUC-Tru-117853	Takifugu rubripes	62.14	0.00e+00	691.00
IUUC-Tni-120256	Tetraodon nigroviridis	65.07	0.00e+00	719.00
IUUC-Tae-123531	Triticum aestivum	27.12	9.00e-06	46.60
IUUC-Tur-126325	Triticum urartu	26.27	3.00e-05	45.10
IUUC-Tbe-127943	Tupaia belangeri	66.33	2.00e-101	361.00
IUUC-Ttr-129246	Tursiops truncatus	89.09	0.00e+00	904.00
IUUC-Xtr-132279	Xenopus tropicalis	60.60	4.00e-175	607.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence