iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130429.12	ENST00000252725.9	ENSP00000252725.5
ENSG00000130429.12	ENST00000445924.5	ENSP00000408508.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-16	61.6	51	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H++ vt++++ ++ +++v+++ D + +vW 
   Q: 51   HNGQVTGIDWaPEsNRIVTCGTDRNAYVWT 80
           9**********888***************6 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the WD repeat ARPC1 family.

Protein Sequence
(Fasta)

MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE HNGQVTGIDW 60
APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGCCTGC ACAGTTGGCG CCCACCGGCA TCAGCGTGAA GGGAGCTCCT CGCTGGCTGC 60
CGACGGGGCT GCAGGGCTCG CTAGCCGCTC ACCTGCGTGT GAGCGCGGAG CCCGCAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR030141--ARC1B
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0036284--C:tubulobulbar complex
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0006928--P:movement of cell or subcellular component
GO:0032355--P:response to estradiol
GO:0043627--P:response to estrogen

KEGG

hsa:10095

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000669	Aegilops tauschii	44.84	2.00e-64	239.00
IUUC-Aml-001709	Ailuropoda melanoleuca	96.54	0.00e+00	730.00
IUUC-Aly-006568	Arabidopsis lyrata	41.08	1.00e-79	290.00
IUUC-Ath-006683	Arabidopsis thaliana	41.62	6.00e-80	291.00
IUUC-Ame-011512	Astyanax mexicanus	80.86	0.00e+00	655.00
IUUC-Bta-012442	Bos taurus	95.96	0.00e+00	723.00
IUUC-Bol-016274	Brassica oleracea	40.97	4.00e-82	298.00
IUUC-Bra-016790	Brassica rapa	40.70	1.00e-80	293.00
IUUC-Cja-019899	Callithrix jacchus	97.86	0.00e+00	756.00
IUUC-Cfa-020067	Canis familiaris	96.24	0.00e+00	728.00
IUUC-Cpo-022461	Cavia porcellus	98.92	0.00e+00	739.00
IUUC-Cre-022590	Chlamydomonas reinhardtii	35.20	3.00e-35	141.00
IUUC-Csa-023277	Chlorocebus sabaeus	90.59	0.00e+00	694.00
IUUC-Dre-028141	Danio rerio	80.59	0.00e+00	647.00
IUUC-Dor-030559	Dipodomys ordii	96.77	0.00e+00	736.00
IUUC-Ete-032299	Echinops telfairi	94.35	0.00e+00	739.00
IUUC-Eca-033593	Equus caballus	96.25	0.00e+00	726.00
IUUC-Fca-036254	Felis catus	97.85	0.00e+00	738.00
IUUC-Fal-037453	Ficedula albicollis	88.50	0.00e+00	696.00
IUUC-Gmo-038471	Gadus morhua	70.05	1.00e-162	565.00
IUUC-Gga-040898	Gallus gallus	87.90	0.00e+00	698.00
IUUC-Gac-042236	Gasterosteus aculeatus	74.80	6.00e-177	613.00
IUUC-Gma-042803	Glycine max	40.80	3.00e-79	288.00
IUUC-Ggo-045355	Gorilla gorilla	83.38	2.00e-171	595.00
IUUC-Itr-048596	Ictidomys tridecemlineatus	97.85	0.00e+00	744.00
IUUC-Kpa-049288	Komagataella pastoris	41.64	9.00e-76	277.00
IUUC-Lch-049679	Latimeria chalumnae	78.98	0.00e+00	637.00
IUUC-Lpe-050869	Leersia perrieri	41.23	5.00e-78	285.00
IUUC-Loc-052140	Lepisosteus oculatus	80.59	0.00e+00	633.00
IUUC-Laf-054287	Loxodonta africana	93.09	0.00e+00	693.00
IUUC-Meu-056302	Macropus eugenii	90.59	0.00e+00	713.00
IUUC-Mtr-057659	Medicago truncatula	40.21	6.00e-82	297.00
IUUC-Mga-059279	Meleagris gallopavo	87.90	0.00e+00	699.00
IUUC-Mmr-060752	Microcebus murinus	97.51	0.00e+00	725.00
IUUC-Mdo-062836	Monodelphis domestica	86.56	0.00e+00	673.00
IUUC-Mmu-064099	Mus musculus	96.28	0.00e+00	728.00
IUUC-Mpu-066247	Mustela putorius furo	97.04	0.00e+00	717.00
IUUC-Mlu-067571	Myotis lucifugus	96.77	0.00e+00	748.00
IUUC-Nle-069492	Nomascus leucogenys	85.48	4.00e-174	603.00
IUUC-Opr-070519	Ochotona princeps	99.12	4.00e-135	474.00
IUUC-Ont-071316	Oreochromis niloticus	76.38	3.00e-176	611.00
IUUC-Oan-072692	Ornithorhynchus anatinus	88.98	0.00e+00	703.00
IUUC-Ocu-074187	Oryctolagus cuniculus	93.28	0.00e+00	714.00
IUUC-Oba-075379	Oryza barthii	41.37	1.00e-78	287.00
IUUC-Obr-076404	Oryza brachyantha	41.76	2.00e-79	289.00
IUUC-Ogl-077409	Oryza glaberrima	38.96	1.00e-72	266.00
IUUC-Ogu-078759	Oryza glumaepatula	41.37	1.00e-78	286.00
IUUC-Oin-079118	Oryza indica	41.42	2.00e-79	289.00
IUUC-Olo-081055	Oryza longistaminata	40.73	2.00e-69	256.00
IUUC-Ome-081281	Oryza meridionalis	41.37	2.00e-78	286.00
IUUC-Oni-083043	Oryza nivara	41.37	1.00e-78	287.00
IUUC-Oru-084839	Oryza rufipogon	41.37	1.00e-78	287.00
IUUC-Osa-085377	Oryza sativa	41.42	2.00e-79	289.00
IUUC-Oga-088610	Otolemur garnettii	97.85	0.00e+00	738.00
IUUC-Oar-089639	Ovis aries	94.61	0.00e+00	707.00
IUUC-Ptr-091023	Pan troglodytes	99.73	0.00e+00	745.00
IUUC-Pan-091727	Papio anubis	99.46	0.00e+00	754.00
IUUC-Pfo-097058	Poecilia formosa	74.54	4.00e-176	610.00
IUUC-Pab-098238	Pongo abelii	99.73	0.00e+00	750.00
IUUC-Pca-100580	Procavia capensis	94.35	0.00e+00	712.00
IUUC-Ppe-101681	Prunus persica	41.69	3.00e-81	295.00
IUUC-Pva-102928	Pteropus vampyrus	94.62	0.00e+00	699.00
IUUC-Rno-104846	Rattus norvegicus	96.77	0.00e+00	730.00
IUUC-Sly-111048	Solanum lycopersicum	42.32	2.00e-78	286.00
IUUC-Sar-113404	Sorex araneus	78.57	6.00e-158	550.00
IUUC-Sbi-114685	Sorghum bicolor	41.53	4.00e-78	285.00
IUUC-Tru-118106	Takifugu rubripes	74.47	5.00e-178	616.00
IUUC-Tni-120079	Tetraodon nigroviridis	75.79	1.00e-179	622.00
IUUC-Tae-125810	Triticum aestivum	37.23	4.00e-71	261.00
IUUC-Tur-126640	Triticum urartu	39.50	4.00e-69	255.00
IUUC-Ttr-128698	Tursiops truncatus	97.04	0.00e+00	734.00
IUUC-Vvi-131647	Vitis vinifera	41.76	1.00e-80	293.00
IUUC-Xtr-131893	Xenopus tropicalis	83.60	0.00e+00	663.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence