iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000036352.16	ENSMUST00000036509.13	ENSMUSP00000040220.7
ENSMUSG00000036352.16	ENSMUST00000136750.2	ENSMUSP00000123115.1
ENSMUSG00000036352.16	ENSMUST00000146363.7	ENSMUSP00000117683.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	1.40e-18	67.5	298	330
ULD/UDP/UBQ/UBQ_PIM	1.50e-15	58.0	14	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraannnleaAveyLl 39
           +  l+eMGFd++e++ aLr +nn+ +aA+e+Ll
   Q: 298  VISLMEMGFDEKEVIDALRVNNNQQNAACEWLL 330
           5679****************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vp....peqqkLIyaG..kiLkDdttLselgikdgsvvhlvvkksk 75
           ++l++++ +g+e+ +e++ed++ve+lKe + k+     ++    ++++kLI+a+  ++L+D++t+ e +i+d++v++l++k+ +
   Q: 14   LRLHICAADGAEWLEEATEDTSVEKLKESCLKHGAhgsLEdpknVTHHKLIHAAseRVLSDSKTILEENIQDQDVLLLIKKRVP 97
           589******************************66767447778***********************************99865 PP

Organism

Mus musculus

Functional Description
(View)

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).

Protein Sequence
(Fasta)

MFVQEEKIFA GKVLRLHICA ADGAEWLEEA TEDTSVEKLK ESCLKHGAHG SLEDPKNVTH 60
HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRVPSPL PKMADVSAEE KKKQEQKAPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCTCCGGG CGGCTACGGC GACACGGGCA GTGGCAGCAA GGGTACAGCT CCTGCCCCTT 60
CAGTGACGGG CGGCGGAGCT GACAGGAGCC GGGGCGGGGC GGCGGCGGCC AGCGAAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50030--UBA

Pfam

PF00627--UBA

SMART

SM00727--STI1
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016567--P:protein ubiquitination

KEGG

mmu:98766

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002260	Ailuropoda melanoleuca	84.91	1.00e-163	568.00
IUUC-Apl-003707	Anas platyrhynchos	81.42	6.00e-133	466.00
IUUC-Aca-004298	Anolis carolinensis	76.60	4.00e-16	75.90
IUUC-Ame-010990	Astyanax mexicanus	75.59	2.00e-153	535.00
IUUC-Bta-012350	Bos taurus	83.86	4.00e-179	620.00
IUUC-Cja-019641	Callithrix jacchus	80.94	6.00e-142	496.00
IUUC-Cfa-020817	Canis familiaris	87.35	0.00e+00	662.00
IUUC-Cpo-022281	Cavia porcellus	87.25	1.00e-179	622.00
IUUC-Csa-023235	Chlorocebus sabaeus	87.78	0.00e+00	660.00
IUUC-Cho-024473	Choloepus hoffmanni	84.11	1.00e-130	459.00
IUUC-Cin-025423	Ciona intestinalis	31.31	4.00e-43	168.00
IUUC-Csv-026357	Ciona savignyi	31.38	3.00e-35	142.00
IUUC-Dre-028611	Danio rerio	76.39	3.00e-162	564.00
IUUC-Dno-029898	Dasypus novemcinctus	84.11	1.00e-159	555.00
IUUC-Dor-030157	Dipodomys ordii	89.50	8.00e-157	546.00
IUUC-Dme-032139	Drosophila melanogaster	28.70	1.00e-22	100.00
IUUC-Ete-032241	Echinops telfairi	78.50	5.00e-35	141.00
IUUC-Eca-033465	Equus caballus	86.63	0.00e+00	636.00
IUUC-Eeu-034757	Erinaceus europaeus	89.40	1.00e-92	333.00
IUUC-Fca-035878	Felis catus	81.71	1.00e-166	579.00
IUUC-Fal-037270	Ficedula albicollis	80.38	2.00e-151	528.00
IUUC-Gmo-038625	Gadus morhua	77.62	5.00e-167	580.00
IUUC-Gga-041270	Gallus gallus	79.71	2.00e-174	604.00
IUUC-Gac-041881	Gasterosteus aculeatus	76.39	3.00e-165	574.00
IUUC-Ggo-045434	Gorilla gorilla	87.29	0.00e+00	658.00
IUUC-Hsa-046531	Homo sapiens	87.53	0.00e+00	658.00
IUUC-Itr-048688	Ictidomys tridecemlineatus	88.67	2.00e-163	568.00
IUUC-Lch-050375	Latimeria chalumnae	79.95	3.00e-166	578.00
IUUC-Loc-052806	Lepisosteus oculatus	78.47	3.00e-162	564.00
IUUC-Laf-054021	Loxodonta africana	83.86	0.00e+00	661.00
IUUC-Mcc-054798	Macaca mulatta	85.64	0.00e+00	628.00
IUUC-Meu-056193	Macropus eugenii	61.37	1.00e-101	363.00
IUUC-Mga-059853	Meleagris gallopavo	74.94	8.00e-156	543.00
IUUC-Mmr-061109	Microcebus murinus	87.50	0.00e+00	652.00
IUUC-Mdo-062799	Monodelphis domestica	81.66	1.00e-167	582.00
IUUC-Mpu-066105	Mustela putorius furo	83.99	2.00e-122	431.00
IUUC-Mlu-067997	Myotis lucifugus	84.82	7.00e-99	353.00
IUUC-Nle-070022	Nomascus leucogenys	87.53	0.00e+00	659.00
IUUC-Ont-072395	Oreochromis niloticus	76.60	2.00e-162	565.00
IUUC-Oan-073631	Ornithorhynchus anatinus	83.10	2.00e-142	498.00
IUUC-Ola-086861	Oryzias latipes	76.37	6.00e-74	271.00
IUUC-Oga-088505	Otolemur garnettii	85.33	0.00e+00	655.00
IUUC-Oar-090395	Ovis aries	83.37	2.00e-180	624.00
IUUC-Ptr-091265	Pan troglodytes	86.55	0.00e+00	644.00
IUUC-Pan-091760	Papio anubis	87.78	0.00e+00	660.00
IUUC-Psi-092977	Pelodiscus sinensis	81.14	8.00e-119	419.00
IUUC-Pfo-097495	Poecilia formosa	77.78	2.00e-96	345.00
IUUC-Pab-097995	Pongo abelii	85.41	2.00e-163	568.00
IUUC-Pca-100468	Procavia capensis	64.36	2.00e-103	369.00
IUUC-Pva-102145	Pteropus vampyrus	85.82	7.00e-179	619.00
IUUC-Rno-105119	Rattus norvegicus	98.53	0.00e+00	690.00
IUUC-Sha-106496	Sarcophilus harrisii	82.89	8.00e-164	569.00
IUUC-Tgu-116846	Taeniopygia guttata	79.60	7.00e-163	566.00
IUUC-Tru-118687	Takifugu rubripes	75.30	4.00e-162	564.00
IUUC-Tni-119838	Tetraodon nigroviridis	77.26	2.00e-162	565.00
IUUC-Tbe-127323	Tupaia belangeri	68.52	7.00e-107	380.00
IUUC-Ttr-129174	Tursiops truncatus	71.15	8.00e-143	499.00
IUUC-Vpa-130792	Vicugna pacos	71.77	3.00e-125	441.00
IUUC-Xtr-132912	Xenopus tropicalis	73.20	3.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence