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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046765
UUCD1 version UUC-HoS-00109
Ensembl Protein ID ENSP00000471303.1
UniProt Accession Q13263; O00677; Q7Z632; Q93040; Q96IM1; TIF1B_HUMAN
Genbank Protein ID AAB37341.1; CAA66150.1; AAB51517.1; AAH04978.1; AAH07390.2; AAH52986.1; AAA74954.1
Protein Name Transcription intermediary factor 1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KRAB-interacting protein 1; Nuclear corepressor KAP-1; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; Tripartite motif-containing protein 28
Genbank Nucleotide ID U78773; X97548; U95040; BC004978; BC007390; BC052986; U31657
Gene Name TRIM28; KAP1; RNF96; TIF1B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130726.11 ENST00000593582.5 ENSP00000472586.1
ENSG00000130726.11 ENST00000253024.9 ENSP00000253024.4
ENSG00000130726.11 ENST00000341753.10 ENSP00000342232.5
ENSG00000130726.11 ENST00000597136.1 ENSP00000471303.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18082607; 18406149; 18488044; 19584288
E3 activity/RING/PHD PHD 18082607; 18406149; 18488044; 19584288
Classification
Family E-value Score Start End
E3 activity/RING/PHD 2.70e-08 35.5 251 295
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vC+++g+    lv+C++C+ +fH +C+ ++  +++p++e w C+ C+
   Q: 251  TICRVCQKPGD----LVMCNQCEFCFHLDCHLPA-LQDVPGEE-WSCSLCH 295
           68*********....*******************.*******8.******7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).
 Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) (PubMed:23543754). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). Acts as a corepressor for ZFP568 (By similarity).
Protein Sequence
(Fasta)
IYFQLHRALK MIVDPVEPHG EMKFQWDLNA WTKSAEAFGK IVAERPGTNS TGPAPMAPPR 60
APGPLSKQGS GSSQPMEVQE GYGFGSEPHV SGVKRSRSGE GEVSGLMRKV PRVSLERLDL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046765|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGGCGGCGA AGAGACGCGG GTTGAGGAAG AGGGACGGAT TGCCCATGCG CTTGGGCGCA 60
CAGCGGCCCG CTTCTGTGTG GTCTGGAGGT GGAGCTGAGA GGGGAATCAC ACTCTATAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046765|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF00643--zf-B_box
PF14634--zf-RING_5
SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING
Gene Ontology

GO:0005719--C:nuclear euchromatin
GO:0005720--C:nuclear heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0070087--F:chromo shadow domain binding
GO:0003677--F:DNA binding
GO:0035851--F:Krueppel-associated box domain binding
GO:1990841--F:promoter-specific chromatin binding
GO:0004672--F:protein kinase activity
GO:0003723--F:RNA binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060028--P:convergent extension involved in axis elongation
GO:0016569--P:covalent chromatin modification
GO:0043045--P:DNA methylation involved in embryo development
GO:0006281--P:DNA repair
GO:0007566--P:embryo implantation
GO:0060669--P:embryonic placenta morphogenesis
GO:0001837--P:epithelial to mesenchymal transition
GO:0045087--P:innate immune response
GO:1901536--P:negative regulation of DNA demethylation
GO:0045869--P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1902187--P:negative regulation of viral release from host cell
GO:0043388--P:positive regulation of DNA binding
GO:0045739--P:positive regulation of DNA repair
GO:0090309--P:positive regulation of methylation-dependent chromatin silencing
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0046777--P:protein autophosphorylation
GO:0051259--P:protein oligomerization
GO:0016925--P:protein sumoylation
GO:0007265--P:Ras protein signal transduction
GO:2000653--P:regulation of genetic imprinting
GO:0006367--P:transcription initiation from RNA polymerase II promoter
KEGG hsa:10155
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Dor-030744 Dipodomys ordii 90.19 0.00e+00 733.00
Created Date 25-Jun-2017

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