iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19906849; 19077536; 17205079; 9267026

Classification

Family	E-value	Score	Start	End
E2/UBC	2.10e-56	189.6	5	139
UBD/UBC-like/UBD_UBC	9.40e-84	278.5	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R++kel++l +dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+t+i+hPn+++nG++Cl+il+  ++Wspal++
   Q: 5    RINKELQDLGRDPPAQCSAGPVGD-DLFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--SQWSPALTI 99
           89**********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vllsi+sll++pnp++pl  e+a+++k++re+y++ +r
   Q: 100  SKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAR 139
           ************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskv 98
           ri+kel+dl rd++aq+sa++v+ddlf+++ati+gppdspy+ggvfflti++ptdypfkppkvaf+t+iyhpninsngsicldilrsqws+alt+skv
   Q: 5    RINKELQDLGRDPPAQCSAGPVGDDLFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKV 102
           8************************************************************************************************* PP
   S: 99   llslcslladaepddplvaeiariyktdkekykriarewt 138
           lls+csll+d++pddplv+eiariyktd+eky++ arewt
   Q: 103  LLSICSLLCDPNPDDPLVPEIARIYKTDREKYNELAREWT 142
           ***************************************8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes.

Protein Sequence
(Fasta)

MALKRINKEL QDLGRDPPAQ CSAGPVGDDL FHWQATIMGP PDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTGAATT GGCACGTCGG CCTTGCCAGA CCAGCGCTCT GGAGTGAATT TAAATTTTAA 60
AATAACGCCC TGTCAATTCA GTTGTAGAAC TCAGTAGCTA GTCGGAAAGT TTTCAAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005875--C:microtubule associated complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051276--P:chromosome organization
GO:0001745--P:compound eye morphogenesis
GO:0001751--P:compound eye photoreceptor cell differentiation
GO:0048132--P:female germ-line stem cell asymmetric division
GO:0030718--P:germ-line stem cell population maintenance
GO:0007140--P:male meiosis
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0016322--P:neuron remodeling
GO:0097039--P:protein linear polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031647--P:regulation of protein stability
GO:0045676--P:regulation of R7 cell differentiation
GO:0007286--P:spermatid development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG7425

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000142	Aegilops tauschii	78.91	2.00e-69	253.00
IUUC-Aml-001563	Ailuropoda melanoleuca	89.12	3.00e-78	282.00
IUUC-Atr-002782	Amborella trichopoda	80.27	3.00e-70	255.00
IUUC-Apl-004043	Anas platyrhynchos	91.84	4.00e-79	285.00
IUUC-Aca-005236	Anolis carolinensis	94.56	1.00e-81	293.00
IUUC-Aly-006221	Arabidopsis lyrata	80.27	7.00e-71	258.00
IUUC-Ath-007700	Arabidopsis thaliana	80.27	5.00e-70	255.00
IUUC-Ago-007967	Ashbya gossypii	82.31	3.00e-73	265.00
IUUC-Acl-008266	Aspergillus clavatus	87.76	9.00e-76	274.00
IUUC-Afl-008709	Aspergillus flavus	80.28	8.00e-69	253.00
IUUC-Afu-008956	Aspergillus fumigatus	88.44	4.00e-76	275.00
IUUC-Ani-009401	Aspergillus nidulans	86.39	1.00e-74	270.00
IUUC-Ang-009725	Aspergillus niger	86.40	1.00e-62	231.00
IUUC-Aor-010157	Aspergillus oryzae	87.07	2.00e-75	273.00
IUUC-Ate-010438	Aspergillus terreus	87.07	5.00e-75	271.00
IUUC-Ame-011657	Astyanax mexicanus	95.89	3.00e-81	292.00
IUUC-Bgr-012238	Blumeria graminis	81.63	7.00e-71	258.00
IUUC-Bta-013158	Bos taurus	94.56	1.00e-81	293.00
IUUC-Bci-013661	Botrytis cinerea	86.39	7.00e-76	274.00
IUUC-Bdi-014561	Brachypodium distachyon	78.91	7.00e-70	254.00
IUUC-Bol-015722	Brassica oleracea	80.95	1.00e-70	257.00
IUUC-Bra-017985	Brassica rapa	80.27	1.00e-70	257.00
IUUC-Cel-018362	Caenorhabditis elegans	96.60	1.00e-83	300.00
IUUC-Cja-019886	Callithrix jacchus	94.56	1.00e-81	293.00
IUUC-Cfa-020436	Canis familiaris	94.56	1.00e-81	293.00
IUUC-Cpo-021714	Cavia porcellus	92.52	7.00e-80	288.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	81.63	7.00e-71	258.00
IUUC-Csa-023668	Chlorocebus sabaeus	89.12	3.00e-78	282.00
IUUC-Cho-024987	Choloepus hoffmanni	89.12	3.00e-78	282.00
IUUC-Cin-025379	Ciona intestinalis	89.04	3.00e-78	282.00
IUUC-Csv-025835	Ciona savignyi	83.56	8.00e-65	238.00
IUUC-Cgl-026490	Colletotrichum gloeosporioides	87.07	2.00e-75	273.00
IUUC-Cne-026957	Cryptococcus neoformans	82.88	1.00e-71	260.00
IUUC-Cme-027220	Cyanidioschyzon merolae	86.39	2.00e-74	270.00
IUUC-Dre-027758	Danio rerio	95.24	3.00e-82	296.00
IUUC-Dno-028952	Dasypus novemcinctus	95.00	3.00e-78	282.00
IUUC-Dor-030323	Dipodomys ordii	91.84	2.00e-79	286.00
IUUC-Dse-031397	Dothistroma septosporum	87.07	1.00e-75	274.00
IUUC-Ete-032540	Echinops telfairi	89.12	3.00e-78	282.00
IUUC-Eca-034167	Equus caballus	89.12	3.00e-78	282.00
IUUC-Eeu-034766	Erinaceus europaeus	94.29	7.00e-76	274.00
IUUC-Fca-035917	Felis catus	93.88	2.00e-81	293.00
IUUC-Fal-036904	Ficedula albicollis	93.57	3.00e-77	279.00
IUUC-Fox-038021	Fusarium oxysporum	87.07	3.00e-75	272.00
IUUC-Fso-038297	Fusarium solani	86.39	7.00e-75	271.00
IUUC-Gmo-038898	Gadus morhua	93.71	1.00e-78	283.00
IUUC-Ggr-039912	Gaeumannomyces graminis	82.24	3.00e-71	259.00
IUUC-Gga-041015	Gallus gallus	95.24	5.00e-82	295.00
IUUC-Gac-042516	Gasterosteus aculeatus	93.20	8.00e-80	287.00
IUUC-Gma-043923	Glycine max	80.27	3.00e-70	256.00
IUUC-Ggo-045361	Gorilla gorilla	92.52	1.00e-79	287.00
IUUC-Hsa-045885	Homo sapiens	94.56	1.00e-81	293.00
IUUC-Hvu-047546	Hordeum vulgare	76.87	6.00e-68	248.00
IUUC-Itr-048882	Ictidomys tridecemlineatus	92.57	4.00e-79	285.00
IUUC-Kpa-049290	Komagataella pastoris	80.95	1.00e-71	260.00
IUUC-Lch-050109	Latimeria chalumnae	87.76	2.00e-77	279.00
IUUC-Lpe-051194	Leersia perrieri	78.91	2.00e-69	254.00
IUUC-Loc-052838	Lepisosteus oculatus	92.52	1.00e-79	287.00
IUUC-Lma-053121	Leptosphaeria maculans	87.07	5.00e-76	275.00
IUUC-Laf-053580	Loxodonta africana	95.00	4.00e-78	282.00
IUUC-Mcc-055421	Macaca mulatta	92.52	1.00e-79	287.00
IUUC-Meu-056462	Macropus eugenii	92.09	1.00e-75	273.00
IUUC-Mor-057235	Magnaporthe oryzae	86.39	7.00e-75	271.00
IUUC-Mpo-057596	Magnaporthe poae	82.24	7.00e-71	258.00
IUUC-Mtr-058532	Medicago truncatula	78.91	4.00e-69	252.00
IUUC-Mla-059189	Melampsora laricipopulina	82.31	3.00e-70	256.00
IUUC-Mga-059237	Meleagris gallopavo	93.57	4.00e-77	278.00
IUUC-Mvi-060397	Microbotryum violaceum	83.67	5.00e-73	265.00
IUUC-Mmr-060889	Microcebus murinus	95.24	5.00e-82	295.00
IUUC-Mdo-062962	Monodelphis domestica	94.56	1.00e-81	293.00
IUUC-Mmu-063796	Mus musculus	95.24	5.00e-82	295.00
IUUC-Mac-065211	Musa acuminata	80.27	3.00e-70	256.00
IUUC-Mpu-066604	Mustela putorius furo	91.10	9.00e-79	284.00
IUUC-Mlu-067573	Myotis lucifugus	88.57	2.00e-74	269.00
IUUC-Nfi-068599	Neosartorya fischeri	88.44	4.00e-76	275.00
IUUC-Ncr-068677	Neurospora crassa	85.71	2.00e-74	270.00
IUUC-Nle-069715	Nomascus leucogenys	92.52	1.00e-79	287.00
IUUC-Opr-070191	Ochotona princeps	93.53	1.00e-76	276.00
IUUC-Ont-071766	Oreochromis niloticus	93.88	3.00e-81	292.00
IUUC-Oan-073026	Ornithorhynchus anatinus	91.49	9.00e-76	275.00
IUUC-Ocu-074315	Oryctolagus cuniculus	94.56	1.00e-81	293.00
IUUC-Oba-075411	Oryza barthii	78.91	2.00e-69	253.00
IUUC-Obr-076658	Oryza brachyantha	78.91	2.00e-69	253.00
IUUC-Ogl-076968	Oryza glaberrima	79.59	6.00e-70	254.00
IUUC-Ogu-078981	Oryza glumaepatula	78.91	2.00e-69	253.00
IUUC-Oin-079659	Oryza indica	79.59	6.00e-70	254.00
IUUC-Olo-080786	Oryza longistaminata	78.91	2.00e-69	253.00
IUUC-Ome-081967	Oryza meridionalis	78.91	4.00e-69	252.00
IUUC-Oni-082391	Oryza nivara	79.59	6.00e-70	256.00
IUUC-Opu-083833	Oryza punctata	78.91	3.00e-69	253.00
IUUC-Oru-085167	Oryza rufipogon	79.59	8.00e-70	256.00
IUUC-Osa-086003	Oryza sativa	79.59	6.00e-70	254.00
IUUC-Ola-086331	Oryzias latipes	93.88	3.00e-81	292.00
IUUC-Olu-087615	Ostreococcus lucimarinus	78.23	1.00e-66	244.00
IUUC-Oga-088477	Otolemur garnettii	92.47	1.00e-79	287.00
IUUC-Oar-090038	Ovis aries	93.88	2.00e-81	293.00
IUUC-Ptr-090707	Pan troglodytes	94.56	1.00e-81	293.00
IUUC-Pan-092143	Papio anubis	94.56	1.00e-81	293.00
IUUC-Psi-094076	Pelodiscus sinensis	93.88	2.00e-81	293.00
IUUC-Pma-094405	Petromyzon marinus	94.81	3.00e-74	269.00
IUUC-Pno-094765	Phaeosphaeria nodorum	87.07	5.00e-76	275.00
IUUC-Ppa-095564	Physcomitrella patens	80.27	3.00e-70	256.00
IUUC-Pfo-096753	Poecilia formosa	93.88	3.00e-81	292.00
IUUC-Pab-097764	Pongo abelii	94.56	1.00e-81	293.00
IUUC-Pop-099586	Populus trichocarpa	80.27	4.00e-70	255.00
IUUC-Pca-100678	Procavia capensis	89.12	3.00e-78	282.00
IUUC-Ppe-101431	Prunus persica	80.95	8.00e-71	258.00
IUUC-Pva-102770	Pteropus vampyrus	89.12	3.00e-78	282.00
IUUC-Pgr-103381	Puccinia graminis	83.67	7.00e-71	259.00
IUUC-Ptt-103723	Puccinia triticina	79.29	2.00e-62	230.00
IUUC-Pte-104015	Pyrenophora teres	87.07	9.00e-76	274.00
IUUC-Pyt-104701	Pyrenophora triticirepentis	87.07	9.00e-76	274.00
IUUC-Rno-105498	Rattus norvegicus	93.88	2.00e-81	293.00
IUUC-Sce-106153	Saccharomyces cerevisiae	81.94	6.00e-71	258.00
IUUC-Sha-106489	Sarcophilus harrisii	85.52	3.00e-75	272.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	87.07	3.00e-75	272.00
IUUC-Spo-108032	Schizosaccharomyces pombe	87.07	3.00e-75	272.00
IUUC-Ssl-108443	Sclerotinia sclerotiorum	87.07	3.00e-76	276.00
IUUC-Smo-109317	Selaginella moellendorffii	80.27	4.00e-70	255.00
IUUC-Sit-109936	Setaria italica	78.23	2.00e-69	254.00
IUUC-Sly-111055	Solanum lycopersicum	80.95	7.00e-71	258.00
IUUC-Stu-112192	Solanum tuberosum	80.95	2.00e-70	256.00
IUUC-Sar-113302	Sorex araneus	94.96	2.00e-77	279.00
IUUC-Sbi-114840	Sorghum bicolor	79.59	5.00e-70	255.00
IUUC-Sre-115037	Sporisorium reilianum	81.94	6.00e-71	258.00
IUUC-Ssc-115391	Sus scrofa	92.52	1.00e-79	287.00
IUUC-Tgu-116727	Taeniopygia guttata	93.88	2.00e-81	293.00
IUUC-Tru-118272	Takifugu rubripes	93.88	8.00e-81	291.00
IUUC-Tsy-118832	Tarsius syrichta	89.80	1.00e-76	277.00
IUUC-Tni-120056	Tetraodon nigroviridis	93.88	8.00e-81	291.00
IUUC-Tca-121413	Theobroma cacao	80.27	3.00e-70	256.00
IUUC-Tre-122125	Trichoderma reesei	85.03	2.00e-73	266.00
IUUC-Tvi-122296	Trichoderma virens	85.03	2.00e-73	266.00
IUUC-Tae-123340	Triticum aestivum	80.27	7.00e-71	258.00
IUUC-Tur-126518	Triticum urartu	78.91	4.00e-70	256.00
IUUC-Tme-126912	Tuber melanosporum	84.35	9.00e-74	267.00
IUUC-Tbe-128122	Tupaia belangeri	91.13	4.00e-57	212.00
IUUC-Ttr-128363	Tursiops truncatus	89.12	3.00e-78	282.00
IUUC-Uma-129648	Ustilago maydis	82.99	8.00e-73	264.00
IUUC-Vda-129695	Verticillium dahliae	87.07	2.00e-75	273.00
IUUC-Vpa-130446	Vicugna pacos	94.29	2.00e-76	278.00
IUUC-Vvi-131016	Vitis vinifera	79.59	3.00e-70	256.00
IUUC-Xtr-132329	Xenopus tropicalis	94.56	1.00e-81	293.00
IUUC-Xma-133829	Xiphophorus maculatus	93.88	3.00e-81	292.00
IUUC-Yli-134353	Yarrowia lipolytica	80.95	2.00e-72	263.00
IUUC-Zma-135569	Zea mays	78.91	2.00e-69	253.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence