iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16275324; 19578373; 19204001

Classification

Family	E-value	Score	Start	End
E2/UBC	2.20e-55	184.7	6	140
UBD/UBC-like/UBD_UBC	2.10e-76	253.1	6	143

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           R++kel++l +dpp+++sa+pv + dl++w++ i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv+f+tki+hPn++++G++Cl+ilk  ++Wspal++++vl
   Q: 6    RIAKELSDLGRDPPASCSAGPVGD-DLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILK--DQWSPALTLSKVL 104
           89**********************.9************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lsi+sll+++np++pl  e+a+++k+++++y+ +++
   Q: 105  LSICSLLTDANPDDPLVPEIAQIYKTDKAKYEATAK 140
           ********************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskvllsl 102
           ri kel+dl rd++a +sa++v+ddl++++a i+gp+dspy ggvffl i++ptdypfkppkv+f+tkiyhpnins+g icldil++qws+altlskvlls+
   Q: 6    RIAKELSDLGRDPPASCSAGPVGDDLYHWQASIMGPSDSPYAGGVFFLSIHFPTDYPFKPPKVNFTTKIYHPNINSSGNICLDILKDQWSPALTLSKVLLSI 107
           89**************************************************************************************************** PP
   S: 103  cslladaepddplvaeiariyktdkekykriarewt 138
           csll+da+pddplv+eia+iyktdk ky+ +a+ewt
   Q: 108  CSLLTDANPDDPLVPEIAQIYKTDKAKYEATAKEWT 143
           ***********************************8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MSSSKRIAKE LSDLGRDPPA SCSAGPVGDD LYHWQASIMG PSDSPYAGGV FFLSIHFPTD 60
YPFKPPKVNF TTKIYHPNIN SSGNICLDIL KDQWSPALTL SKVLLSICSL LTDANPDDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTCCT CCAAGCGTAT TGCCAAGGAA TTAAGTGATT TAGGGAGGTA TGTTAAAAAT 60
AAAATGAATG ATTTTTCTTG ATCTGTAAAG AAAAAGGATT ACTAACATGA GTTTCTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000502--C:proteasome complex
GO:0005524--F:ATP binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034605--P:cellular response to heat
GO:0000209--P:protein polyubiquitination

KEGG

sce:YDR059C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001563	Ailuropoda melanoleuca	80.56	2.00e-69	251.00
IUUC-Apl-004043	Anas platyrhynchos	80.28	2.00e-69	252.00
IUUC-Aca-005236	Anolis carolinensis	80.56	9.00e-71	256.00
IUUC-Aor-010157	Aspergillus oryzae	84.03	3.00e-75	271.00
IUUC-Ame-011657	Astyanax mexicanus	81.94	6.00e-71	257.00
IUUC-Bgr-012238	Blumeria graminis	79.17	9.00e-71	256.00
IUUC-Bta-013158	Bos taurus	80.56	9.00e-71	256.00
IUUC-Cel-018362	Caenorhabditis elegans	80.56	8.00e-71	256.00
IUUC-Cja-019886	Callithrix jacchus	80.56	9.00e-71	256.00
IUUC-Cfa-020436	Canis familiaris	80.56	9.00e-71	256.00
IUUC-Cpo-021714	Cavia porcellus	80.56	3.00e-70	254.00
IUUC-Csa-023668	Chlorocebus sabaeus	80.56	2.00e-69	251.00
IUUC-Cho-024987	Choloepus hoffmanni	80.56	2.00e-69	251.00
IUUC-Cin-025379	Ciona intestinalis	77.78	3.00e-68	248.00
IUUC-Csv-026311	Ciona savignyi	76.39	4.00e-65	237.00
IUUC-Cgl-026490	Colletotrichum gloeosporioides	84.03	2.00e-75	272.00
IUUC-Cme-027220	Cyanidioschyzon merolae	80.56	9.00e-71	256.00
IUUC-Dre-028804	Danio rerio	81.94	3.00e-71	258.00
IUUC-Dno-028952	Dasypus novemcinctus	80.71	4.00e-69	251.00
IUUC-Dse-031397	Dothistroma septosporum	83.33	2.00e-75	271.00
IUUC-Dme-031594	Drosophila melanogaster	81.94	2.00e-71	258.00
IUUC-Ete-032540	Echinops telfairi	80.56	2.00e-69	251.00
IUUC-Eca-034167	Equus caballus	80.56	2.00e-69	251.00
IUUC-Eeu-034766	Erinaceus europaeus	80.71	4.00e-67	244.00
IUUC-Gga-041015	Gallus gallus	81.25	8.00e-71	256.00
IUUC-Gac-041400	Gasterosteus aculeatus	81.25	1.00e-70	256.00
IUUC-Hsa-045885	Homo sapiens	80.56	9.00e-71	256.00
IUUC-Itr-048743	Ictidomys tridecemlineatus	80.56	2.00e-69	251.00
IUUC-Kpa-049290	Komagataella pastoris	92.47	9.00e-79	283.00
IUUC-Lch-050109	Latimeria chalumnae	79.17	3.00e-68	248.00
IUUC-Lma-053121	Leptosphaeria maculans	83.33	2.00e-75	272.00
IUUC-Laf-053580	Loxodonta africana	80.71	6.00e-69	250.00
IUUC-Mor-057235	Magnaporthe oryzae	84.03	4.00e-75	271.00
IUUC-Mpo-057596	Magnaporthe poae	79.19	3.00e-70	254.00
IUUC-Mmr-060889	Microcebus murinus	81.25	8.00e-71	256.00
IUUC-Mmu-063796	Mus musculus	81.25	8.00e-71	256.00
IUUC-Mpu-065724	Mustela putorius furo	80.56	2.00e-69	251.00
IUUC-Mlu-067573	Myotis lucifugus	80.00	4.00e-67	244.00
IUUC-Opr-070191	Ochotona princeps	80.58	3.00e-68	248.00
IUUC-Ont-071403	Oreochromis niloticus	81.94	7.00e-71	256.00
IUUC-Ocu-074315	Oryctolagus cuniculus	80.56	9.00e-71	256.00
IUUC-Ola-086493	Oryzias latipes	81.25	5.00e-70	254.00
IUUC-Olu-087615	Ostreococcus lucimarinus	75.51	2.00e-65	238.00
IUUC-Ptr-090707	Pan troglodytes	80.56	9.00e-71	256.00
IUUC-Pan-092143	Papio anubis	80.56	9.00e-71	256.00
IUUC-Pma-094405	Petromyzon marinus	78.01	5.00e-66	241.00
IUUC-Pno-094765	Phaeosphaeria nodorum	83.33	2.00e-75	272.00
IUUC-Pfo-096323	Poecilia formosa	81.94	1.00e-70	255.00
IUUC-Pab-097764	Pongo abelii	80.56	9.00e-71	256.00
IUUC-Pca-100678	Procavia capensis	80.56	2.00e-69	251.00
IUUC-Pva-102770	Pteropus vampyrus	80.56	2.00e-69	251.00
IUUC-Pgr-103381	Puccinia graminis	80.56	6.00e-69	251.00
IUUC-Ptt-103723	Puccinia triticina	78.57	2.00e-63	232.00
IUUC-Pte-104015	Pyrenophora teres	82.64	5.00e-75	270.00
IUUC-Pyt-104701	Pyrenophora triticirepentis	82.64	5.00e-75	270.00
IUUC-Sha-106489	Sarcophilus harrisii	76.87	1.00e-67	246.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	84.03	6.00e-75	270.00
IUUC-Sar-113302	Sorex araneus	80.58	2.00e-68	248.00
IUUC-Tru-118628	Takifugu rubripes	81.25	3.00e-70	254.00
IUUC-Tni-120056	Tetraodon nigroviridis	79.86	8.00e-70	253.00
IUUC-Ttr-128363	Tursiops truncatus	80.56	2.00e-69	251.00
IUUC-Vda-129695	Verticillium dahliae	84.03	2.00e-75	272.00
IUUC-Vpa-130446	Vicugna pacos	80.00	2.00e-67	246.00
IUUC-Xtr-132284	Xenopus tropicalis	81.94	1.00e-70	256.00
IUUC-Xma-133673	Xiphophorus maculatus	80.56	2.00e-70	255.00
IUUC-Yli-134353	Yarrowia lipolytica	82.64	1.00e-72	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence