iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019223.3	ENSMMUT00000027006.3	ENSMMUP00000025265.2
ENSMMUG00000019223.3	ENSMMUT00000066563.1	ENSMMUP00000043382.1
ENSMMUG00000019223.3	ENSMMUT00000078051.1	ENSMMUP00000041622.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-31	106.2	394	425
UBD/Beta-Prp	3.40e-48	165.4	394	670

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+++v+cl+  s  +ll sGs D+tikvWD+
   Q: 394  GHQGPVWCLCVySMgDLLFSGSSDKTIKVWDT 425
           8*********778889***************6 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           gh+  ++ c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++     l +gs D ti vwd+++ + v t+++h+
   Q: 394  GHQG-PVWCLCVYSMGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGC--KLYSGSADCTIIVWDIQNLQKVNTIRAHD 479
           5555.55569999*******************846678899***************99..6**************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           + v++l +s   + l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v  +  ++l sGs+ +t+++Wd++t ++++ l+    +s
   Q: 480  NPVCTLVSSH--NMLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSY-QTIKIWDIRTLDCIHVLQT-SGGS 561
           *****99999..9******.9*******7368888888**************99..*******9.79***************99.**** PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           vys++++    ++v g + + + +wd++++e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv++
   Q: 562  VYSIAVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTA 648
           *******9..8***********************************99888************************************** PP
   S: 270  vavlsfgdnvlvlgsedskvniwkl 294
            av   ++  l++g+ ds+v++w +
   Q: 649  LAV---SRGRLFSGAVDSTVKVWTC 670
           **9...*****************86 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT STYKQHCRTP 60
SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEEEEPEPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCCGAG GGGGCATCAT GAAGCGGGCT GGCAGTGCTG CCGCTCCCGG GCGGCCGCGG 60
GCGGGTGAGT GTCCCCGCGG CGCGCCCGAC CCGGAGCTCG CGCCTCGGGG CCGCGCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

mcc:695415

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001971	Ailuropoda melanoleuca	97.62	0.00e+00	1262.00
IUUC-Apl-004098	Anas platyrhynchos	95.01	0.00e+00	1200.00
IUUC-Aca-004852	Anolis carolinensis	87.99	0.00e+00	978.00
IUUC-Ame-011275	Astyanax mexicanus	82.86	0.00e+00	936.00
IUUC-Bta-013153	Bos taurus	98.36	0.00e+00	1281.00
IUUC-Cja-019243	Callithrix jacchus	98.01	0.00e+00	1253.00
IUUC-Cfa-020036	Canis familiaris	98.81	0.00e+00	1300.00
IUUC-Cpo-022194	Cavia porcellus	97.90	0.00e+00	1278.00
IUUC-Csa-023363	Chlorocebus sabaeus	99.85	0.00e+00	1311.00
IUUC-Cin-025279	Ciona intestinalis	58.98	0.00e+00	797.00
IUUC-Csv-026163	Ciona savignyi	64.73	0.00e+00	771.00
IUUC-Dre-027998	Danio rerio	90.48	0.00e+00	1110.00
IUUC-Dno-029356	Dasypus novemcinctus	95.98	1.00e-130	458.00
IUUC-Dor-030750	Dipodomys ordii	95.37	0.00e+00	1234.00
IUUC-Eca-033671	Equus caballus	82.64	0.00e+00	992.00
IUUC-Eeu-034765	Erinaceus europaeus	97.70	9.00e-166	577.00
IUUC-Fca-035843	Felis catus	98.51	0.00e+00	1293.00
IUUC-Fal-037237	Ficedula albicollis	93.43	0.00e+00	1238.00
IUUC-Gmo-038779	Gadus morhua	81.37	0.00e+00	1004.00
IUUC-Gga-040579	Gallus gallus	92.99	0.00e+00	1230.00
IUUC-Gac-042233	Gasterosteus aculeatus	85.82	0.00e+00	1116.00
IUUC-Gma-044293	Glycine max	26.81	3.00e-19	89.40
IUUC-Ggo-045147	Gorilla gorilla	99.55	0.00e+00	1306.00
IUUC-Hsa-046117	Homo sapiens	99.40	0.00e+00	1305.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	98.06	0.00e+00	1291.00
IUUC-Lch-050593	Latimeria chalumnae	91.21	0.00e+00	1187.00
IUUC-Loc-052444	Lepisosteus oculatus	90.22	0.00e+00	1214.00
IUUC-Laf-053499	Loxodonta africana	91.14	0.00e+00	1174.00
IUUC-Meu-056610	Macropus eugenii	95.41	0.00e+00	948.00
IUUC-Mtr-057641	Medicago truncatula	27.73	2.00e-19	90.10
IUUC-Mga-060183	Meleagris gallopavo	92.71	0.00e+00	1226.00
IUUC-Mmr-061133	Microcebus murinus	97.07	0.00e+00	1221.00
IUUC-Mdo-062312	Monodelphis domestica	96.13	0.00e+00	1263.00
IUUC-Mmu-063844	Mus musculus	97.01	0.00e+00	1241.00
IUUC-Mpu-066552	Mustela putorius furo	97.76	0.00e+00	1258.00
IUUC-Mlu-067719	Myotis lucifugus	97.61	0.00e+00	1251.00
IUUC-Nle-070045	Nomascus leucogenys	99.20	0.00e+00	1211.00
IUUC-Opr-070927	Ochotona princeps	94.93	0.00e+00	1225.00
IUUC-Ont-072680	Oreochromis niloticus	85.73	0.00e+00	1140.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	3.00e-52	196.00
IUUC-Ogu-077987	Oryza glumaepatula	25.86	3.00e-19	89.70
IUUC-Oru-085210	Oryza rufipogon	25.60	2.00e-19	90.10
IUUC-Ola-087454	Oryzias latipes	86.97	0.00e+00	1177.00
IUUC-Oga-088380	Otolemur garnettii	97.91	0.00e+00	1286.00
IUUC-Oar-089558	Ovis aries	80.79	0.00e+00	1014.00
IUUC-Ptr-091606	Pan troglodytes	99.55	0.00e+00	1306.00
IUUC-Pan-092227	Papio anubis	100.00	0.00e+00	1312.00
IUUC-Psi-093853	Pelodiscus sinensis	86.46	0.00e+00	1020.00
IUUC-Pma-094541	Petromyzon marinus	81.65	7.00e-154	536.00
IUUC-Pfo-096237	Poecilia formosa	88.69	0.00e+00	1128.00
IUUC-Pab-097589	Pongo abelii	99.70	0.00e+00	1309.00
IUUC-Pca-100375	Procavia capensis	94.14	0.00e+00	1182.00
IUUC-Pva-102434	Pteropus vampyrus	98.51	0.00e+00	1289.00
IUUC-Rno-105443	Rattus norvegicus	97.46	0.00e+00	1248.00
IUUC-Sha-106517	Sarcophilus harrisii	95.83	0.00e+00	1258.00
IUUC-Ssc-115990	Sus scrofa	97.46	0.00e+00	1278.00
IUUC-Tgu-117222	Taeniopygia guttata	93.25	0.00e+00	1228.00
IUUC-Tru-118392	Takifugu rubripes	88.43	0.00e+00	1135.00
IUUC-Tni-120220	Tetraodon nigroviridis	87.65	0.00e+00	1128.00
IUUC-Tca-121793	Theobroma cacao	27.11	1.00e-20	94.40
IUUC-Tbe-128045	Tupaia belangeri	99.31	2.00e-161	562.00
IUUC-Ttr-128203	Tursiops truncatus	95.22	0.00e+00	1231.00
IUUC-Xtr-132043	Xenopus tropicalis	91.94	0.00e+00	1243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence