iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000052752.15	ENSMUST00000176652.7	ENSMUSP00000134759.1
ENSMUSG00000052752.15	ENSMUST00000176353.7	ENSMUSP00000135267.1
ENSMUSG00000052752.15	ENSMUST00000176668.7	ENSMUSP00000135586.1
ENSMUSG00000052752.15	ENSMUST00000176086.7	ENSMUSP00000135845.1
ENSMUSG00000052752.15	ENSMUST00000175698.7	ENSMUSP00000135456.1
ENSMUSG00000052752.15	ENSMUST00000177502.7	ENSMUSP00000134970.1
ENSMUSG00000052752.15	ENSMUST00000176237.7	ENSMUSP00000134946.1
ENSMUSG00000052752.15	ENSMUST00000177154.7	ENSMUSP00000135874.1
ENSMUSG00000052752.15	ENSMUST00000177401.7	ENSMUSP00000135341.1
ENSMUSG00000052752.15	ENSMUST00000176178.7	ENSMUSP00000134808.1
ENSMUSG00000052752.15	ENSMUST00000177405.7	ENSMUSP00000135127.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
iRefIndex
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-31	106.2	393	424
UBD/Beta-Prp	3.40e-48	165.5	393	669

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+++v+cl+  s  +ll sGs D+tikvWD+
   Q: 393  GHQGPVWCLCVySMgDLLFSGSSDKTIKVWDT 424
           8*********778889***************6 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           gh+  ++ c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++     l +gs D ti vwd+++ + v t+++h+
   Q: 393  GHQG-PVWCLCVYSMGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGC--KLYSGSADCTIIVWDIQNLQKVNTIRAHD 478
           5555.55569999*******************846678899***************99..6**************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           + v++l +s   + l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v  +  ++l sGs+ +t+++Wd++t ++++ l+    +s
   Q: 479  NPVCTLVSSH--NMLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSY-QTIKIWDIRTLDCIHVLQT-SGGS 560
           *****99999..9******.9*******7368888888**************99..*******9.79***************99.**** PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           vys++++    ++v g + + + +wd++++e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv++
   Q: 561  VYSIAVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTA 647
           *******9..8***********************************99888************************************** PP
   S: 270  vavlsfgdnvlvlgsedskvniwkl 294
            av   ++  l++g+ ds+v++w +
   Q: 648  LAV---SRGRLFSGAVDSTVKVWTC 669
           **9...*****************86 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSSAKSARYD RFSGGPANLP SSDSSGTRME TTFGPTFSTV TTITKADGTG TYKQHRRTPS 60
SSSTLAYSPR DEEDGMPPIN TPRRSDSAIS VRSLHSESSM SLRSTFSLPE EEEEPEPLVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGCTCAA AGCGTGAAGC AGCACCTAGA GTTCCTGAAG TCCGTGAACT ACAAGTTCCG 60
ACCTGCCCCG GGACTTCCGG CTCCTGTATC CTGAAACCTT TCCCGGCCGC GGGCCGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway

KEGG

mmu:224619

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001971	Ailuropoda melanoleuca	95.99	0.00e+00	1243.00
IUUC-Apl-004098	Anas platyrhynchos	95.01	0.00e+00	1201.00
IUUC-Aca-004852	Anolis carolinensis	87.99	0.00e+00	969.00
IUUC-Ame-011275	Astyanax mexicanus	82.94	0.00e+00	935.00
IUUC-Bta-013153	Bos taurus	96.86	0.00e+00	1267.00
IUUC-Cja-019243	Callithrix jacchus	95.72	0.00e+00	1218.00
IUUC-Cfa-020036	Canis familiaris	97.31	0.00e+00	1274.00
IUUC-Cpo-022194	Cavia porcellus	97.30	0.00e+00	1267.00
IUUC-Csa-023363	Chlorocebus sabaeus	97.16	0.00e+00	1273.00
IUUC-Cin-025279	Ciona intestinalis	58.92	0.00e+00	801.00
IUUC-Csv-026163	Ciona savignyi	64.73	0.00e+00	772.00
IUUC-Dre-027998	Danio rerio	90.64	0.00e+00	1114.00
IUUC-Dno-029356	Dasypus novemcinctus	95.98	2.00e-130	457.00
IUUC-Dor-030750	Dipodomys ordii	95.37	0.00e+00	1228.00
IUUC-Eca-033671	Equus caballus	81.45	0.00e+00	978.00
IUUC-Eeu-034765	Erinaceus europaeus	97.70	5.00e-166	577.00
IUUC-Fca-035843	Felis catus	97.31	0.00e+00	1277.00
IUUC-Fal-037237	Ficedula albicollis	93.28	0.00e+00	1235.00
IUUC-Gmo-038779	Gadus morhua	81.83	0.00e+00	1010.00
IUUC-Gga-040579	Gallus gallus	92.84	0.00e+00	1226.00
IUUC-Gac-042233	Gasterosteus aculeatus	86.13	0.00e+00	1121.00
IUUC-Gma-042711	Glycine max	26.81	3.00e-19	89.40
IUUC-Ggo-045147	Gorilla gorilla	96.57	0.00e+00	1265.00
IUUC-Hsa-046117	Homo sapiens	96.57	0.00e+00	1267.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	97.46	0.00e+00	1274.00
IUUC-Lch-050593	Latimeria chalumnae	90.76	0.00e+00	1181.00
IUUC-Loc-052444	Lepisosteus oculatus	90.22	0.00e+00	1217.00
IUUC-Laf-053499	Loxodonta africana	90.67	0.00e+00	1172.00
IUUC-Mcc-055038	Macaca mulatta	97.01	0.00e+00	1270.00
IUUC-Meu-056610	Macropus eugenii	94.81	0.00e+00	941.00
IUUC-Mtr-057641	Medicago truncatula	27.73	3.00e-19	89.70
IUUC-Mga-060183	Meleagris gallopavo	92.41	0.00e+00	1219.00
IUUC-Mmr-061133	Microcebus murinus	95.22	0.00e+00	1196.00
IUUC-Mdo-062312	Monodelphis domestica	95.83	0.00e+00	1259.00
IUUC-Mpu-066552	Mustela putorius furo	96.72	0.00e+00	1240.00
IUUC-Mlu-067719	Myotis lucifugus	96.87	0.00e+00	1239.00
IUUC-Nle-070045	Nomascus leucogenys	97.60	0.00e+00	1192.00
IUUC-Opr-070927	Ochotona princeps	94.33	0.00e+00	1215.00
IUUC-Ont-072680	Oreochromis niloticus	85.59	0.00e+00	1140.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	2.00e-52	196.00
IUUC-Ogu-077987	Oryza glumaepatula	25.86	4.00e-19	89.40
IUUC-Oru-085210	Oryza rufipogon	25.60	2.00e-19	90.10
IUUC-Ola-087454	Oryzias latipes	89.47	0.00e+00	1185.00
IUUC-Oga-088380	Otolemur garnettii	96.72	0.00e+00	1268.00
IUUC-Oar-089558	Ovis aries	79.59	0.00e+00	1004.00
IUUC-Ptr-091606	Pan troglodytes	96.57	0.00e+00	1265.00
IUUC-Pan-092227	Papio anubis	97.01	0.00e+00	1270.00
IUUC-Psi-093853	Pelodiscus sinensis	86.62	0.00e+00	1020.00
IUUC-Pma-094541	Petromyzon marinus	82.28	1.00e-156	545.00
IUUC-Pfo-096237	Poecilia formosa	85.69	0.00e+00	1137.00
IUUC-Pab-097589	Pongo abelii	96.72	0.00e+00	1267.00
IUUC-Pca-100375	Procavia capensis	93.68	0.00e+00	1182.00
IUUC-Pva-102434	Pteropus vampyrus	97.31	0.00e+00	1273.00
IUUC-Rno-105443	Rattus norvegicus	99.40	0.00e+00	1272.00
IUUC-Sha-106517	Sarcophilus harrisii	95.54	0.00e+00	1254.00
IUUC-Ssc-115990	Sus scrofa	96.12	0.00e+00	1258.00
IUUC-Tgu-117222	Taeniopygia guttata	92.95	0.00e+00	1222.00
IUUC-Tru-118392	Takifugu rubripes	89.04	0.00e+00	1145.00
IUUC-Tni-120220	Tetraodon nigroviridis	88.50	0.00e+00	1135.00
IUUC-Tca-121793	Theobroma cacao	27.11	1.00e-20	94.40
IUUC-Tur-126339	Triticum urartu	26.69	2.00e-17	84.00
IUUC-Tbe-128045	Tupaia belangeri	99.31	2.00e-161	562.00
IUUC-Ttr-128203	Tursiops truncatus	93.58	0.00e+00	1207.00
IUUC-Xtr-132043	Xenopus tropicalis	91.64	0.00e+00	1241.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence