iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21285945; 20061341

Classification

Family	E-value	Score	Start	End
DUB/USP	4.30e-88	297.4	285	884

Active Site

Position(s)	Description	Evidence
294	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
840	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqq 90
           +G+ NlgNtCYmN+vLQ+L++ip+++++ll+   + +++e    p ++l+++l++l++     ++k k     +++k+++++ae fsg++q+
   Q: 285  QGFPNLGNTCYMNAVLQSLFAIPSFADDLLT---QGVPWE--YIPFEALIMTLTQLLALKDfcSTKIKRELLGNVKKVISAVAEIFSGNMQN 371
           59*****************************...*****9..68************976645577777777788****************** PP
   S: 91   DaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkee 181
           Da+Efl ++ldql+e+++k +++ ++ +e+++++s+ +++  +  +k   ++++ +F+++l+ +++c++c++   + ep+++ls++++++++
   Q: 372  DAHEFLGQCLDQLKEDMEKlNATLNTGKECGDENSSPQMHVGSAATKVFVCPVVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETK 463
           *****************8888999999***************************************************************** PP
   S: 182  tkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...... 267
             ++s+q++L+ f+keeele    y+c+ ck+k+ ++ ++++++l++vLi+hLkR+sf+++ +   k+n++v++p++L+ls++c++      
   Q: 464  PLPLSIQNSLDLFFKEEELE----YNCQMCKQKS-CVARHTFSRLSRVLIIHLKRYSFNNA-WLLVKNNEQVYIPKSLSLSSYCNEstkppl 549
           *******************9....*******999.8999*******************998.************************999999 PP
   S: 268  ............................................................................................ 267
                                                                                                       
   Q: 550  plsssapvgkcevlevsqemiseinspltpsmkltsessdslvlpvepdknadlqrfqrdcgdasqeqhqrdlengsaleselvhfrdraig 641
           99999999999999999999999999999999999888888888888888888888888888887777777777777777777777777777 PP
   S: 268  ..................................................................................peekqke... 274
                                                                                             p     e   
   Q: 642  ekelpvadslmdqgdislpvmyedggklisspdtrlvevhlqevpqhpelqkyektntfvefnfdsvtestngfydckenriP-----Egsq 728
           77777777777777777777777777777666666666666666666666666666555555555555555555555555550.....0555 PP
   S: 275  ...........................................................................................k 275
                                                                                                       
   Q: 729  gmaeqlqqcieesiideflqqapppgvrkldaqehteetlnqstelrlqkadlnhlgalgsdnpgnknildaentrgeakeltrnvkmgdpL 820
           5555555555556666666666666666666666666666677777777788888888888888888888888888889999999999999* PP
   S: 276  kkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + Y+Li+vv+H G s++sGHY+++v++ +++ W++++D  V+e++e++++e + +++Y++fY++
   Q: 821  QAYRLISVVSHIGsSPNSGHYISDVYDFQKQaWFTYNDLCVSEISETKMQEARLHSGYIFFYMH 884
           ***************************88888*******************999********98 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI FQLSNNIRSV 60
VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD IIHQNKSQQP MKSDDDWSVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGCCCAG GCACCACGCG ACTCTAAGCG CGCCCAAAGC GACCCTCTGC GCAAACTACC 60
CCCGGGGACG ACGTCACCCG TGAGGTCCCG CGGCGCCTCC TCCTAAAGCT CGGCTGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:57663

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019561	Callithrix jacchus	80.04	0.00e+00	1456.00
IUUC-Csa-023566	Chlorocebus sabaeus	91.89	0.00e+00	1724.00
IUUC-Dno-028968	Dasypus novemcinctus	56.89	0.00e+00	956.00
IUUC-Ete-032723	Echinops telfairi	40.67	3.00e-111	395.00
IUUC-Eca-034298	Equus caballus	62.24	0.00e+00	1074.00
IUUC-Ggo-045549	Gorilla gorilla	97.81	0.00e+00	1794.00
IUUC-Laf-054521	Loxodonta africana	56.55	0.00e+00	968.00
IUUC-Mcc-055452	Macaca mulatta	90.78	0.00e+00	1721.00
IUUC-Mmr-061514	Microcebus murinus	63.56	0.00e+00	1129.00
IUUC-Nle-069425	Nomascus leucogenys	93.09	0.00e+00	1761.00
IUUC-Opr-070989	Ochotona princeps	39.33	8.00e-146	511.00
IUUC-Ocu-073810	Oryctolagus cuniculus	49.89	0.00e+00	808.00
IUUC-Oga-088883	Otolemur garnettii	63.68	0.00e+00	1123.00
IUUC-Pca-100925	Procavia capensis	53.25	0.00e+00	875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence