iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000133135.13	ENST00000324342.7	ENSP00000316127.3
ENSG00000133135.13	ENST00000255499.2	ENSP00000255499.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19542455; 20493730

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.40e-05	26.4	277	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e +   d +++l C+H+fh++C+  w         + +CP C+
   Q: 277  CAVCIELYkpNDLVRILTCNHIFHKTCVDPW------LLEHRTCPMCK 318
           *****9985545499****************......9999******6 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

Protein Sequence
(Fasta)

MGPPPGAGVS CRGGCGFSRL LAWCFLLALS PQAPGSRGAE AVWTAYLNVS WRVPHTGVNR 60
TVWELSEEGV YGQDSPLEPV AGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI 120

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Nucleotide Sequence
(Fasta)

TGGAGGAGGG GCAAGCAAAG GGGAATGTAG ATAACTAAAG TGAAATAGAG CTGATGTATC 60
CAGAGGTTAT GTTGCTAGAG GTGAGATCAG TTACCTACGT GCAACTGAAA TTTCAAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042036--P:negative regulation of cytokine biosynthetic process
GO:1904352--P:positive regulation of protein catabolic process in the vacuole
GO:0016579--P:protein deubiquitination
GO:0061462--P:protein localization to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031647--P:regulation of protein stability

KEGG

hsa:79589

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000408	Aegilops tauschii	48.21	1.00e-12	66.20
IUUC-Aml-001674	Ailuropoda melanoleuca	96.29	0.00e+00	830.00
IUUC-Apl-003776	Anas platyrhynchos	66.56	3.00e-106	377.00
IUUC-Aca-004318	Anolis carolinensis	68.17	8.00e-117	413.00
IUUC-Ame-011286	Astyanax mexicanus	45.89	1.00e-84	306.00
IUUC-Bta-013454	Bos taurus	94.20	0.00e+00	813.00
IUUC-Cja-019864	Callithrix jacchus	98.13	0.00e+00	842.00
IUUC-Cfa-020185	Canis familiaris	96.06	0.00e+00	825.00
IUUC-Csa-023224	Chlorocebus sabaeus	97.20	0.00e+00	806.00
IUUC-Cho-024710	Choloepus hoffmanni	79.83	9.00e-146	509.00
IUUC-Cne-026951	Cryptococcus neoformans	34.69	8.00e-11	61.60
IUUC-Dre-028249	Danio rerio	52.73	2.00e-89	323.00
IUUC-Dno-029216	Dasypus novemcinctus	95.94	4.00e-136	477.00
IUUC-Dor-030487	Dipodomys ordii	82.73	0.00e+00	660.00
IUUC-Dse-031357	Dothistroma septosporum	45.21	2.00e-12	67.40
IUUC-Ete-032376	Echinops telfairi	94.58	6.00e-135	473.00
IUUC-Eca-034264	Equus caballus	96.06	0.00e+00	827.00
IUUC-Eeu-034606	Erinaceus europaeus	92.55	4.00e-129	454.00
IUUC-Fca-036503	Felis catus	96.52	0.00e+00	830.00
IUUC-Fal-036671	Ficedula albicollis	60.32	3.00e-112	398.00
IUUC-Gmo-039483	Gadus morhua	47.35	3.00e-80	291.00
IUUC-Gga-040248	Gallus gallus	66.57	1.00e-130	459.00
IUUC-Itr-048362	Ictidomys tridecemlineatus	96.96	0.00e+00	833.00
IUUC-Lch-050549	Latimeria chalumnae	56.97	9.00e-121	426.00
IUUC-Loc-051929	Lepisosteus oculatus	56.25	3.00e-96	345.00
IUUC-Laf-054197	Loxodonta africana	93.97	0.00e+00	781.00
IUUC-Mcc-055146	Macaca mulatta	97.66	0.00e+00	812.00
IUUC-Meu-056649	Macropus eugenii	75.98	2.00e-162	565.00
IUUC-Mga-059520	Meleagris gallopavo	65.68	1.00e-130	459.00
IUUC-Mmr-061502	Microcebus murinus	96.50	0.00e+00	800.00
IUUC-Mdo-062875	Monodelphis domestica	64.95	3.00e-122	431.00
IUUC-Mmu-064235	Mus musculus	95.33	0.00e+00	822.00
IUUC-Mpu-066452	Mustela putorius furo	91.52	7.00e-170	589.00
IUUC-Mlu-067189	Myotis lucifugus	94.66	0.00e+00	799.00
IUUC-Ncr-068771	Neurospora crassa	41.18	2.00e-13	70.90
IUUC-Nle-070026	Nomascus leucogenys	98.60	0.00e+00	818.00
IUUC-Opr-070435	Ochotona princeps	71.05	2.00e-94	338.00
IUUC-Oan-073238	Ornithorhynchus anatinus	74.83	6.00e-117	413.00
IUUC-Ocu-074960	Oryctolagus cuniculus	95.79	0.00e+00	786.00
IUUC-Ola-086348	Oryzias latipes	47.04	3.00e-77	281.00
IUUC-Oga-088543	Otolemur garnettii	94.86	0.00e+00	816.00
IUUC-Oar-089599	Ovis aries	94.20	0.00e+00	813.00
IUUC-Ptr-091576	Pan troglodytes	95.61	6.00e-174	603.00
IUUC-Pan-091690	Papio anubis	97.44	0.00e+00	807.00
IUUC-Psi-093642	Pelodiscus sinensis	77.82	8.00e-106	376.00
IUUC-Pfo-096270	Poecilia formosa	41.64	7.00e-76	277.00
IUUC-Pab-097965	Pongo abelii	98.36	0.00e+00	814.00
IUUC-Pva-102991	Pteropus vampyrus	84.97	4.00e-175	607.00
IUUC-Rno-105667	Rattus norvegicus	95.33	0.00e+00	823.00
IUUC-Sha-107293	Sarcophilus harrisii	77.48	1.00e-154	539.00
IUUC-Ssl-108451	Sclerotinia sclerotiorum	54.00	1.00e-12	67.80
IUUC-Sar-113682	Sorex araneus	95.49	6.00e-143	499.00
IUUC-Ssc-115583	Sus scrofa	96.29	0.00e+00	826.00
IUUC-Tgu-117406	Taeniopygia guttata	58.33	2.00e-81	295.00
IUUC-Tru-118147	Takifugu rubripes	44.05	9.00e-74	270.00
IUUC-Tsy-118918	Tarsius syrichta	95.33	0.00e+00	769.00
IUUC-Tni-120865	Tetraodon nigroviridis	45.91	6.00e-70	257.00
IUUC-Ttr-128640	Tursiops truncatus	96.29	0.00e+00	803.00
IUUC-Vpa-130536	Vicugna pacos	88.19	0.00e+00	736.00
IUUC-Xma-133114	Xiphophorus maculatus	48.14	8.00e-78	283.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence