iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134253.9	ENST00000497970.5	ENSP00000431261.1
ENSG00000134253.9	ENST00000256649.8	ENSP00000256649.4
ENSG00000134253.9	ENST00000369464.7	ENSP00000358476.3
ENSG00000134253.9	ENST00000369461.3	ENSP00000358473.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	5.40e-08	34.9	29	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.........................pglknssskefrCPlCr 46
           C++Cl  fk  p++lpC H+ +++Cl+++                         + ++ +s+  ++CP+C+
   Q: 29   CPLCLGLFKA-PRLLPCLHTVCTTCLEQLepfsvvdirggdsdtssegsifqelKPRSLQSQIGILCPVCD 98
           ********99.***************999999****************999999777778999999****5 PP

Organism

Homo sapiens

Functional Description
(View)

May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Protein Sequence
(Fasta)

MSENRKPLLG FVSKLTSGTA LGNSGKTHCP LCLGLFKAPR LLPCLHTVCT TCLEQLEPFS 60
VVDIRGGDSD TSSEGSIFQE LKPRSLQSQI GILCPVCDAQ VDLPMGGVKA LTIDHLAVND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTACACAGG ACTGTGGAAT CCCGGGTGAC ATTCAACTCC TTAGGTCATC TGCACTCCCC 60
CCGGACCGGA AAACAAAGCC TTCCCGAGCC CGACAAGGAG GGTGGCGCTC CCTGGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027267--AH/BAR-dom
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0060348--P:bone development

KEGG

hsa:80263

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002020	Ailuropoda melanoleuca	91.55	0.00e+00	1028.00
IUUC-Ame-010865	Astyanax mexicanus	47.62	3.00e-131	462.00
IUUC-Bta-012744	Bos taurus	88.97	0.00e+00	1010.00
IUUC-Cel-018225	Caenorhabditis elegans	22.96	5.00e-17	84.00
IUUC-Cja-019162	Callithrix jacchus	93.10	0.00e+00	1043.00
IUUC-Cfa-020163	Canis familiaris	91.38	0.00e+00	1021.00
IUUC-Csa-023746	Chlorocebus sabaeus	96.55	0.00e+00	1087.00
IUUC-Cho-024414	Choloepus hoffmanni	78.69	0.00e+00	758.00
IUUC-Dre-028598	Danio rerio	48.34	4.00e-119	421.00
IUUC-Dno-029616	Dasypus novemcinctus	88.81	0.00e+00	998.00
IUUC-Dor-030216	Dipodomys ordii	82.04	6.00e-69	254.00
IUUC-Dme-031817	Drosophila melanogaster	29.89	8.00e-67	249.00
IUUC-Ete-032434	Echinops telfairi	85.71	0.00e+00	901.00
IUUC-Eca-034410	Equus caballus	90.34	0.00e+00	1012.00
IUUC-Eeu-034954	Erinaceus europaeus	86.57	0.00e+00	977.00
IUUC-Fca-035410	Felis catus	91.55	0.00e+00	1030.00
IUUC-Gmo-039232	Gadus morhua	47.87	3.00e-134	472.00
IUUC-Gac-042350	Gasterosteus aculeatus	45.00	5.00e-107	381.00
IUUC-Ggo-045080	Gorilla gorilla	97.93	0.00e+00	1101.00
IUUC-Itr-048145	Ictidomys tridecemlineatus	88.62	0.00e+00	999.00
IUUC-Lch-049464	Latimeria chalumnae	57.49	0.00e+00	661.00
IUUC-Loc-052772	Lepisosteus oculatus	52.48	8.00e-74	271.00
IUUC-Mcc-055349	Macaca mulatta	94.83	0.00e+00	1060.00
IUUC-Meu-056674	Macropus eugenii	65.86	0.00e+00	742.00
IUUC-Mmr-061225	Microcebus murinus	90.96	0.00e+00	1015.00
IUUC-Mdo-062597	Monodelphis domestica	62.52	0.00e+00	682.00
IUUC-Mmu-063099	Mus musculus	86.03	0.00e+00	972.00
IUUC-Mlu-067034	Myotis lucifugus	88.10	0.00e+00	989.00
IUUC-Nle-069855	Nomascus leucogenys	97.24	0.00e+00	1124.00
IUUC-Opr-070954	Ochotona princeps	89.27	0.00e+00	989.00
IUUC-Ont-071292	Oreochromis niloticus	49.29	6.00e-132	464.00
IUUC-Oga-087909	Otolemur garnettii	87.59	0.00e+00	995.00
IUUC-Oar-089619	Ovis aries	88.97	0.00e+00	1007.00
IUUC-Ptr-090712	Pan troglodytes	98.28	0.00e+00	1108.00
IUUC-Pan-092806	Papio anubis	96.21	0.00e+00	1080.00
IUUC-Psi-093414	Pelodiscus sinensis	64.45	0.00e+00	707.00
IUUC-Pfo-096848	Poecilia formosa	46.96	2.00e-130	459.00
IUUC-Pab-098353	Pongo abelii	95.86	0.00e+00	1080.00
IUUC-Pca-100183	Procavia capensis	87.44	0.00e+00	979.00
IUUC-Pva-102140	Pteropus vampyrus	87.24	0.00e+00	992.00
IUUC-Rno-105886	Rattus norvegicus	86.03	0.00e+00	962.00
IUUC-Sha-107458	Sarcophilus harrisii	64.72	0.00e+00	693.00
IUUC-Sar-112944	Sorex araneus	67.59	0.00e+00	679.00
IUUC-Ssc-116231	Sus scrofa	89.14	0.00e+00	1003.00
IUUC-Tgu-116859	Taeniopygia guttata	56.60	5.00e-158	550.00
IUUC-Tru-118209	Takifugu rubripes	48.93	7.00e-132	464.00
IUUC-Tni-120290	Tetraodon nigroviridis	48.57	5.00e-118	418.00
IUUC-Tbe-128111	Tupaia belangeri	91.00	0.00e+00	886.00
IUUC-Ttr-128584	Tursiops truncatus	87.07	0.00e+00	940.00
IUUC-Vvi-131620	Vitis vinifera	30.00	5.00e-05	40.80
IUUC-Xtr-132137	Xenopus tropicalis	43.28	6.00e-104	371.00
IUUC-Xma-134298	Xiphophorus maculatus	47.96	9.00e-133	467.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence