iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135686.12	ENST00000564996.5	ENSP00000456743.1
ENSG00000135686.12	ENST00000258157.9	ENSP00000258157.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.40e-12	48.2	46	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv+lv ++++++ah+  La +S++F+++f+ +++e   +++ve+ + ++  ++a+++FlY g+l 
   Q: 46   CDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAF-QKEVELIGASYIGLKAVVDFLYGGELV 110
           8************************************9.************************996 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH 60
RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTGGCGGA GCCATGGCTG CGCAGCGGGC TGGCCGGGGG TCTCCTGAAC CCGGGCCCCG 60
CCGCCCCGAC CGCCCGGCCC CGCCGCCGGG GCTGTCCCCG CCGCGTCCGT AGCGCGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030585--KLHL36
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:79786

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001869	Ailuropoda melanoleuca	96.43	0.00e+00	1140.00
IUUC-Apl-003806	Anas platyrhynchos	85.85	0.00e+00	1067.00
IUUC-Ame-010908	Astyanax mexicanus	65.94	0.00e+00	765.00
IUUC-Bta-013146	Bos taurus	94.64	0.00e+00	1133.00
IUUC-Cja-019679	Callithrix jacchus	98.71	0.00e+00	1060.00
IUUC-Cfa-021265	Canis familiaris	96.59	0.00e+00	1138.00
IUUC-Cpo-021740	Cavia porcellus	88.13	0.00e+00	1042.00
IUUC-Csa-023308	Chlorocebus sabaeus	99.68	0.00e+00	1207.00
IUUC-Dre-028415	Danio rerio	63.65	0.00e+00	736.00
IUUC-Dno-029110	Dasypus novemcinctus	94.80	0.00e+00	1185.00
IUUC-Dor-030909	Dipodomys ordii	93.82	0.00e+00	1139.00
IUUC-Ete-032401	Echinops telfairi	86.83	0.00e+00	1039.00
IUUC-Eca-033226	Equus caballus	96.26	0.00e+00	1134.00
IUUC-Eeu-035083	Erinaceus europaeus	88.58	0.00e+00	979.00
IUUC-Fca-036492	Felis catus	95.60	0.00e+00	1117.00
IUUC-Fal-036853	Ficedula albicollis	81.30	0.00e+00	998.00
IUUC-Gga-040333	Gallus gallus	85.53	0.00e+00	1066.00
IUUC-Ggo-044986	Gorilla gorilla	99.68	0.00e+00	1206.00
IUUC-Itr-048578	Ictidomys tridecemlineatus	95.33	0.00e+00	1143.00
IUUC-Lch-050297	Latimeria chalumnae	78.86	0.00e+00	989.00
IUUC-Loc-052521	Lepisosteus oculatus	77.17	0.00e+00	971.00
IUUC-Laf-054504	Loxodonta africana	95.61	0.00e+00	1163.00
IUUC-Mcc-055755	Macaca mulatta	99.68	0.00e+00	1207.00
IUUC-Mga-059643	Meleagris gallopavo	85.85	0.00e+00	1068.00
IUUC-Mmr-061423	Microcebus murinus	82.73	0.00e+00	852.00
IUUC-Mdo-062792	Monodelphis domestica	89.08	0.00e+00	1064.00
IUUC-Mmu-063252	Mus musculus	85.53	0.00e+00	1065.00
IUUC-Mpu-065736	Mustela putorius furo	93.99	0.00e+00	1172.00
IUUC-Mlu-068053	Myotis lucifugus	95.45	0.00e+00	1163.00
IUUC-Nle-069092	Nomascus leucogenys	87.34	0.00e+00	1041.00
IUUC-Opr-070407	Ochotona princeps	88.57	0.00e+00	1053.00
IUUC-Ont-071640	Oreochromis niloticus	65.27	0.00e+00	768.00
IUUC-Oan-073279	Ornithorhynchus anatinus	87.18	0.00e+00	1116.00
IUUC-Ocu-074611	Oryctolagus cuniculus	93.18	0.00e+00	1147.00
IUUC-Ola-086508	Oryzias latipes	63.84	0.00e+00	790.00
IUUC-Oga-088008	Otolemur garnettii	96.42	0.00e+00	1164.00
IUUC-Oar-089990	Ovis aries	92.89	0.00e+00	1063.00
IUUC-Ptr-091303	Pan troglodytes	99.84	0.00e+00	1208.00
IUUC-Pan-092647	Papio anubis	99.68	0.00e+00	1207.00
IUUC-Pfo-096164	Poecilia formosa	56.60	0.00e+00	704.00
IUUC-Pab-097655	Pongo abelii	99.51	0.00e+00	1201.00
IUUC-Pca-101101	Procavia capensis	93.99	0.00e+00	1142.00
IUUC-Rno-105423	Rattus norvegicus	86.34	0.00e+00	1067.00
IUUC-Sha-107381	Sarcophilus harrisii	89.45	0.00e+00	1120.00
IUUC-Tgu-116910	Taeniopygia guttata	84.90	0.00e+00	1038.00
IUUC-Tru-117937	Takifugu rubripes	61.11	0.00e+00	728.00
IUUC-Tsy-119012	Tarsius syrichta	92.53	0.00e+00	937.00
IUUC-Tni-120541	Tetraodon nigroviridis	61.89	0.00e+00	765.00
IUUC-Tbe-127500	Tupaia belangeri	96.26	0.00e+00	1165.00
IUUC-Ttr-128572	Tursiops truncatus	94.97	0.00e+00	1144.00
IUUC-Xtr-132103	Xenopus tropicalis	76.95	0.00e+00	1012.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence