iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135870.11	ENST00000367696.6	ENSP00000356669.2
ENSG00000135870.11	ENST00000367694.2	ENSP00000356667.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18036806; 19221396

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00047	22.3	14	51

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCP 43
           C+iC + f    + p++l+CgH+ ++ Cl+k+         +  CP
   Q: 14   CPICTQTFdetIRKPISLGCGHTVCKMCLNKL--------HRKACP 51
           ****9999555333999************999........344566 PP

Organism

Homo sapiens

Functional Description
(View)

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).

Protein Sequence
(Fasta)

MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD 60
IELLPVNSAL LQLVGAQVPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGCCCCTGC TGCAGGAGCA GCCTCAGCAG CAGCAGGTGG GAGGCCGGAG GCGGTGCTGG 60
CGGTGGCGGC GGCAGCCGTG GCCCGGCGGC CTGGGACAGA ATCAGAGTCA ACGGTGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032671--RC3H1
IPR027370--Znf-RING_LisH
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00642--zf-CCCH
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0010494--C:cytoplasmic stress granule
GO:0000932--C:P-body
GO:0003730--F:mRNA 3'-UTR binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001782--P:B cell homeostasis
GO:0071347--P:cellular response to interleukin-1
GO:0033962--P:cytoplasmic mRNA processing body assembly
GO:0048535--P:lymph node development
GO:0046007--P:negative regulation of activated T cell proliferation
GO:0030889--P:negative regulation of B cell proliferation
GO:0002635--P:negative regulation of germinal center formation
GO:0045623--P:negative regulation of T-helper cell differentiation
GO:0000956--P:nuclear-transcribed mRNA catabolic process
GO:0000288--P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0002634--P:regulation of germinal center formation
GO:0043488--P:regulation of mRNA stability
GO:0050856--P:regulation of T cell receptor signaling pathway
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0061470--P:T follicular helper cell differentiation

KEGG

hsa:149041

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001700	Ailuropoda melanoleuca	96.91	0.00e+00	1959.00
IUUC-Apl-003290	Anas platyrhynchos	86.82	0.00e+00	1842.00
IUUC-Aca-004905	Anolis carolinensis	84.99	0.00e+00	1754.00
IUUC-Ame-011475	Astyanax mexicanus	64.18	0.00e+00	1211.00
IUUC-Cja-019907	Callithrix jacchus	98.50	0.00e+00	2054.00
IUUC-Cfa-020679	Canis familiaris	96.82	0.00e+00	1959.00
IUUC-Cpo-022110	Cavia porcellus	91.90	0.00e+00	1942.00
IUUC-Csa-024166	Chlorocebus sabaeus	99.08	0.00e+00	1991.00
IUUC-Dno-029870	Dasypus novemcinctus	95.18	0.00e+00	981.00
IUUC-Dor-030934	Dipodomys ordii	87.34	0.00e+00	1490.00
IUUC-Dme-031708	Drosophila melanogaster	64.51	8.00e-163	567.00
IUUC-Ete-032652	Echinops telfairi	95.93	0.00e+00	1389.00
IUUC-Eca-033236	Equus caballus	96.56	0.00e+00	1927.00
IUUC-Eeu-035091	Erinaceus europaeus	83.30	0.00e+00	877.00
IUUC-Fca-035773	Felis catus	97.18	0.00e+00	1965.00
IUUC-Fal-036972	Ficedula albicollis	86.64	0.00e+00	1850.00
IUUC-Gmo-039303	Gadus morhua	80.03	0.00e+00	892.00
IUUC-Ggo-044691	Gorilla gorilla	93.33	0.00e+00	1914.00
IUUC-Itr-048266	Ictidomys tridecemlineatus	94.11	0.00e+00	1061.00
IUUC-Lch-050667	Latimeria chalumnae	74.50	0.00e+00	1536.00
IUUC-Loc-052404	Lepisosteus oculatus	69.11	0.00e+00	1327.00
IUUC-Laf-053618	Loxodonta africana	97.54	0.00e+00	1916.00
IUUC-Mcc-054692	Macaca mulatta	99.12	0.00e+00	2074.00
IUUC-Meu-056025	Macropus eugenii	85.34	0.00e+00	941.00
IUUC-Mmr-061188	Microcebus murinus	97.44	0.00e+00	1968.00
IUUC-Mdo-063035	Monodelphis domestica	92.24	0.00e+00	1893.00
IUUC-Mmu-064146	Mus musculus	92.85	0.00e+00	1946.00
IUUC-Mpu-066217	Mustela putorius furo	96.29	0.00e+00	1944.00
IUUC-Mlu-068023	Myotis lucifugus	95.59	0.00e+00	1954.00
IUUC-Nle-069506	Nomascus leucogenys	99.38	0.00e+00	2078.00
IUUC-Opr-070587	Ochotona princeps	83.02	0.00e+00	1597.00
IUUC-Ont-071278	Oreochromis niloticus	62.91	0.00e+00	1198.00
IUUC-Oan-073500	Ornithorhynchus anatinus	91.44	0.00e+00	1954.00
IUUC-Ocu-074299	Oryctolagus cuniculus	96.15	0.00e+00	1847.00
IUUC-Ola-086665	Oryzias latipes	61.56	0.00e+00	1214.00
IUUC-Oga-088519	Otolemur garnettii	90.22	0.00e+00	1758.00
IUUC-Oar-089246	Ovis aries	96.49	0.00e+00	1847.00
IUUC-Ptr-091102	Pan troglodytes	99.91	0.00e+00	2088.00
IUUC-Pan-091952	Papio anubis	99.03	0.00e+00	2071.00
IUUC-Pfo-097227	Poecilia formosa	61.75	0.00e+00	1171.00
IUUC-Pab-097975	Pongo abelii	96.03	0.00e+00	1979.00
IUUC-Pca-101127	Procavia capensis	91.54	0.00e+00	1319.00
IUUC-Pva-102431	Pteropus vampyrus	88.17	0.00e+00	1748.00
IUUC-Sha-106690	Sarcophilus harrisii	91.45	0.00e+00	1914.00
IUUC-Ssc-116189	Sus scrofa	97.35	0.00e+00	1909.00
IUUC-Tgu-116527	Taeniopygia guttata	87.63	0.00e+00	1862.00
IUUC-Tru-118389	Takifugu rubripes	62.19	0.00e+00	1220.00
IUUC-Tsy-119193	Tarsius syrichta	93.47	0.00e+00	1887.00
IUUC-Tni-119790	Tetraodon nigroviridis	64.12	0.00e+00	1115.00
IUUC-Tbe-127445	Tupaia belangeri	90.80	0.00e+00	1538.00
IUUC-Ttr-128877	Tursiops truncatus	96.56	0.00e+00	1899.00
IUUC-Vpa-130054	Vicugna pacos	94.76	0.00e+00	914.00
IUUC-Xtr-132274	Xenopus tropicalis	78.75	0.00e+00	1602.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence