iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005370

UUCD1 version

UUC-AnC-01010

Ensembl Protein ID

ENSACAP00000002401.3

UniProt Accession

G1KAT4; G1KAT4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

usp37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000002348.3	ENSACAT00000002462.3	ENSACAP00000002401.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-81	273.9	330	943
UBD/Alpha-Helix/UIM	2.30e-06	27.0	821	839

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G+ NlgNtCYmN++LQ+L++i++l+++ll+   ++++++  k p ++l++ +  l+++    + + k+   +++++a++++ae+fsgy
   Q: 330  QGFANLGNTCYMNAILQSLFSIQSLANDLLK---QNIPWK--KVPCNALIRRFSVLLAKKDvcSFEAKKELLKKVKNAISATAERFSGY 413
           59*****************************...*****9..5799***********99877799999999****************** PP
   S: 88   eqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +k+++ e +++ed+s    + + + ++ ++++i ++++++++++i+c+ c+++ +++e+f+dls++
   Q: 414  MQNDAHEFLSQCLDQLKEDMEKlNKTWKSEPSSGEDSSVGRISDDLSATRVYTCPIITNLEFEVQHSIICKMCGETVTKREQFNDLSID 502
           ********************77444444444555555555555788999999************************************* PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++  ++ s+qd+L+ f+++ee+e    y+cekc++k+ a  ++k+++lP+vLilhLkR+s++ + + ++k+ ++v +p+ L+l++
   Q: 503  LPRRKKLLPSrSIQDSLDLFFRAEEIE----YSCEKCNGKS-ALVTHKFSRLPRVLILHLKRYSYNVALSLNHKVGQQVVIPRFLTLQS 586
           **9998876569**************9....********99.99********************************************* PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 587  HCTEstrpplnlgwsaqstisrplkvsqmvnscsvspstpsrkytfkfkgpvvstmdsdseeeplkrpvtnspkqcdkeqqrddlekss 675
           ****9999999999999999999999999999999999999999999999999999999999999999999999888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 676  krvrtesekasestnagfdgmnedellaavlemskketslslshdedkptnspdtgfgdeelqdlpdntepmdvekprvsaesgfatft 764
           88888887777777777777777777777777777777777777777777777777777777777666666666666666666666666 PP
   S: 268  ...............................peekqke................................................... 274
                                          +     e                                                   
   Q: 765  eitkdfdenkenktpegaqgdidwlqqydleR-----Ereeqelqqalaqslqeqqeareqkedddlkratelslqefnnslldslasd 848
           66666666555555555555555555555550.....0555555556666666666666677777778888888888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+L++vv+H G ++ssGHY+++v++ +++ W++++D  V+ ++e++v++++++++Y
   Q: 849  edsgnedfldmeyseaeaeelkrnaetgelPNSYRLTSVVSHIGdTSSSGHYISDVYDIRKQaWFTCNDLAVSRIQEASVQSDRDRSGY 937
           888888888888888889999999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 938  IFFYMH 943
           ****98 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ed++L +A +lSlqE ++
   Q: 821  KEDDDLKRATELSLQEFNN 839
           69**************876 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MTLLKLCGSI RMHSMQTGTT KWKEGTFEIV DKDSKVTLVI HYNAGGIPKM FQLNRNIKKV 60
VVQPNKGKLC RLMITLKDSS FLMVDKIPLK DAEEMKLFLE GVQNGTHAAV KIPLGSGSFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTTGCGTT TCCTATCAGA TTTAATTTCA TAAATTATTT GTATGAAAAC ATGACTCTGC 60
TGAAATTATG TGGATCTATT CGCATGCATA GCATGCAGAC TGGGACTACC AAATGGAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100552832

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	70.04	0.00e+00	1265.00
IUUC-Apl-004033	Anas platyrhynchos	75.41	0.00e+00	1366.00
IUUC-Ame-011884	Astyanax mexicanus	56.81	0.00e+00	939.00
IUUC-Bta-012725	Bos taurus	68.78	0.00e+00	1236.00
IUUC-Cja-019939	Callithrix jacchus	69.61	0.00e+00	1199.00
IUUC-Cfa-020835	Canis familiaris	70.99	0.00e+00	1285.00
IUUC-Cpo-022067	Cavia porcellus	69.36	0.00e+00	1134.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.88	2.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	70.67	0.00e+00	1241.00
IUUC-Cho-024390	Choloepus hoffmanni	55.87	2.00e-101	363.00
IUUC-Cin-025496	Ciona intestinalis	37.26	1.00e-43	171.00
IUUC-Csv-025812	Ciona savignyi	34.85	5.00e-41	162.00
IUUC-Dre-028255	Danio rerio	55.96	0.00e+00	909.00
IUUC-Dno-028986	Dasypus novemcinctus	69.15	0.00e+00	1212.00
IUUC-Dor-031062	Dipodomys ordii	62.65	0.00e+00	676.00
IUUC-Ete-032359	Echinops telfairi	62.20	5.00e-172	598.00
IUUC-Eca-033964	Equus caballus	69.42	0.00e+00	1249.00
IUUC-Eeu-034492	Erinaceus europaeus	67.21	2.00e-176	612.00
IUUC-Fca-036359	Felis catus	70.25	0.00e+00	1264.00
IUUC-Fal-037640	Ficedula albicollis	75.67	0.00e+00	1359.00
IUUC-Gmo-039600	Gadus morhua	53.70	0.00e+00	902.00
IUUC-Gga-040126	Gallus gallus	74.64	0.00e+00	1313.00
IUUC-Gac-041557	Gasterosteus aculeatus	53.89	0.00e+00	864.00
IUUC-Ggo-045571	Gorilla gorilla	67.97	0.00e+00	1084.00
IUUC-Hsa-046043	Homo sapiens	69.44	0.00e+00	1214.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	69.77	0.00e+00	1212.00
IUUC-Lch-050357	Latimeria chalumnae	62.36	0.00e+00	986.00
IUUC-Loc-052849	Lepisosteus oculatus	59.67	0.00e+00	993.00
IUUC-Laf-054570	Loxodonta africana	70.02	0.00e+00	1219.00
IUUC-Mcc-054989	Macaca mulatta	69.40	0.00e+00	1142.00
IUUC-Meu-056273	Macropus eugenii	64.90	2.00e-74	274.00
IUUC-Mga-059814	Meleagris gallopavo	72.44	0.00e+00	1305.00
IUUC-Mmr-061726	Microcebus murinus	69.96	0.00e+00	1231.00
IUUC-Mdo-062974	Monodelphis domestica	72.96	0.00e+00	1322.00
IUUC-Mmu-064069	Mus musculus	68.88	0.00e+00	1199.00
IUUC-Mpu-066008	Mustela putorius furo	69.50	0.00e+00	1234.00
IUUC-Mlu-068224	Myotis lucifugus	37.01	4.00e-137	482.00
IUUC-Nle-069259	Nomascus leucogenys	69.40	0.00e+00	1212.00
IUUC-Opr-070882	Ochotona princeps	64.07	8.00e-110	391.00
IUUC-Ont-072441	Oreochromis niloticus	54.30	0.00e+00	887.00
IUUC-Oan-073151	Ornithorhynchus anatinus	78.88	3.00e-116	411.00
IUUC-Ocu-074879	Oryctolagus cuniculus	69.55	0.00e+00	1217.00
IUUC-Ola-087007	Oryzias latipes	52.47	0.00e+00	825.00
IUUC-Oga-088385	Otolemur garnettii	69.27	0.00e+00	1219.00
IUUC-Oar-090305	Ovis aries	69.20	0.00e+00	1248.00
IUUC-Ptr-091299	Pan troglodytes	69.61	0.00e+00	1214.00
IUUC-Pan-091996	Papio anubis	70.66	0.00e+00	1222.00
IUUC-Psi-093176	Pelodiscus sinensis	75.82	0.00e+00	1386.00
IUUC-Pma-094331	Petromyzon marinus	46.06	0.00e+00	714.00
IUUC-Ppa-095732	Physcomitrella patens	27.24	1.00e-21	98.60
IUUC-Pfo-096503	Poecilia formosa	54.75	0.00e+00	867.00
IUUC-Pab-098543	Pongo abelii	74.40	0.00e+00	687.00
IUUC-Pca-101099	Procavia capensis	67.91	0.00e+00	982.00
IUUC-Pva-103163	Pteropus vampyrus	67.93	0.00e+00	837.00
IUUC-Rno-105766	Rattus norvegicus	68.78	0.00e+00	1198.00
IUUC-Sha-106610	Sarcophilus harrisii	67.34	0.00e+00	1208.00
IUUC-Sar-113624	Sorex araneus	36.23	7.00e-83	301.00
IUUC-Ssc-116353	Sus scrofa	68.88	0.00e+00	1223.00
IUUC-Tgu-116971	Taeniopygia guttata	74.74	0.00e+00	1335.00
IUUC-Tru-117932	Takifugu rubripes	45.87	9.00e-135	474.00
IUUC-Tsy-119185	Tarsius syrichta	65.35	0.00e+00	813.00
IUUC-Tni-119842	Tetraodon nigroviridis	61.71	3.00e-113	402.00
IUUC-Tbe-127281	Tupaia belangeri	57.67	9.00e-127	447.00
IUUC-Ttr-128177	Tursiops truncatus	75.17	0.00e+00	1040.00
IUUC-Vpa-130031	Vicugna pacos	71.09	0.00e+00	1281.00
IUUC-Xtr-132949	Xenopus tropicalis	65.04	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence