iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012725

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37

Genbank Nucleotide ID

AAFC03077731

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000016572.4	ENSBTAT00000038243.3	ENSBTAP00000038058.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-86	290.7	343	952

Active Site

Position(s)	Description	Evidence
352	Nucleophile	{ECO:0000250\|UniProtKB:Q86T82, ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
908	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk+++ e    +++++d+   + ++ +++++ ++++++++++i+c+ c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKIEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKVCGEIIPKREQFNDLSIDL 511
           ********************55.8888888877777888888...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP++LilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppfnlgwsaqmavsrplkasqmvnscitspstpsknftfksktslalsldsdsedelkrsvalshrlcemsgseqqqedlekd 684
           ***99999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  skscriepdkselensgfdgmseeellaavleiskreaspslshedddkptsspdtgfaeddiqempenpdsvetekpktitepdpasf 773
           88888888888888888888888888888888877777777777777777777777777777777777777776666666666666666 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 774  teitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdslgsd 857
           6666666655555550.....05555555555555555555666666666666666777777777777777777888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++Y
   Q: 858  edsgnedvldmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSGY 946
           888888888888888888889999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 947  IFFYMH 952
           ****98 PP

Organism

Bos taurus

Functional Description
(View)

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEVV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLNAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCCTC TGAAGATACA TGGCCCTATC AGAATTCGAA GTATGCAGAC TGGGATTACA 60
AAATGGAAAG AAGGATCCTT TGAAGTTGTG GAAAAAGAGA ATAAAGTCAG CCTAGTAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:407168

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	95.92	0.00e+00	1762.00
IUUC-Apl-004033	Anas platyrhynchos	77.23	0.00e+00	1443.00
IUUC-Aca-005370	Anolis carolinensis	70.15	0.00e+00	1325.00
IUUC-Ame-011884	Astyanax mexicanus	58.84	0.00e+00	994.00
IUUC-Cja-019939	Callithrix jacchus	94.59	0.00e+00	1687.00
IUUC-Cfa-020835	Canis familiaris	96.12	0.00e+00	1814.00
IUUC-Cpo-022067	Cavia porcellus	92.41	0.00e+00	1555.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	1.00e-23	105.00
IUUC-Csa-023085	Chlorocebus sabaeus	94.39	0.00e+00	1749.00
IUUC-Cho-024390	Choloepus hoffmanni	86.27	2.00e-166	579.00
IUUC-Cin-025496	Ciona intestinalis	37.25	6.00e-43	169.00
IUUC-Csv-025812	Ciona savignyi	36.61	1.00e-41	164.00
IUUC-Dre-028255	Danio rerio	57.57	0.00e+00	949.00
IUUC-Dno-028986	Dasypus novemcinctus	94.09	0.00e+00	1703.00
IUUC-Dor-031062	Dipodomys ordii	78.96	0.00e+00	876.00
IUUC-Ete-032359	Echinops telfairi	82.15	0.00e+00	820.00
IUUC-Eca-033964	Equus caballus	95.01	0.00e+00	1753.00
IUUC-Eeu-034492	Erinaceus europaeus	86.05	0.00e+00	832.00
IUUC-Fca-036359	Felis catus	95.20	0.00e+00	1748.00
IUUC-Fal-037640	Ficedula albicollis	77.53	0.00e+00	1414.00
IUUC-Gmo-039600	Gadus morhua	54.71	0.00e+00	935.00
IUUC-Gga-040126	Gallus gallus	77.13	0.00e+00	1373.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.26	0.00e+00	916.00
IUUC-Ggo-045571	Gorilla gorilla	90.65	0.00e+00	1521.00
IUUC-Hsa-046043	Homo sapiens	94.69	0.00e+00	1705.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	92.35	0.00e+00	1681.00
IUUC-Lch-050357	Latimeria chalumnae	64.37	0.00e+00	1044.00
IUUC-Loc-052849	Lepisosteus oculatus	61.12	0.00e+00	1005.00
IUUC-Laf-054570	Loxodonta africana	93.08	0.00e+00	1671.00
IUUC-Mcc-054989	Macaca mulatta	94.29	0.00e+00	1614.00
IUUC-Meu-056273	Macropus eugenii	64.33	6.00e-172	598.00
IUUC-Mga-059814	Meleagris gallopavo	75.51	0.00e+00	1374.00
IUUC-Mmr-061726	Microcebus murinus	93.58	0.00e+00	1731.00
IUUC-Mdo-062974	Monodelphis domestica	84.67	0.00e+00	1572.00
IUUC-Mmu-064069	Mus musculus	88.58	0.00e+00	1599.00
IUUC-Mpu-066008	Mustela putorius furo	95.31	0.00e+00	1719.00
IUUC-Nle-069259	Nomascus leucogenys	94.39	0.00e+00	1707.00
IUUC-Opr-070882	Ochotona princeps	77.51	5.00e-139	488.00
IUUC-Ont-072441	Oreochromis niloticus	55.27	0.00e+00	934.00
IUUC-Oan-073151	Ornithorhynchus anatinus	82.07	6.00e-119	420.00
IUUC-Ocu-074879	Oryctolagus cuniculus	92.86	0.00e+00	1699.00
IUUC-Ola-087007	Oryzias latipes	54.79	0.00e+00	897.00
IUUC-Oga-088385	Otolemur garnettii	92.29	0.00e+00	1709.00
IUUC-Oar-090305	Ovis aries	98.88	0.00e+00	1819.00
IUUC-Ptr-091299	Pan troglodytes	94.50	0.00e+00	1714.00
IUUC-Pan-091996	Papio anubis	94.54	0.00e+00	1695.00
IUUC-Psi-093176	Pelodiscus sinensis	78.59	0.00e+00	1451.00
IUUC-Pma-094331	Petromyzon marinus	48.22	0.00e+00	759.00
IUUC-Ppa-095732	Physcomitrella patens	30.38	3.00e-24	107.00
IUUC-Pfo-096503	Poecilia formosa	56.28	0.00e+00	932.00
IUUC-Pab-098543	Pongo abelii	93.83	0.00e+00	913.00
IUUC-Pca-101099	Procavia capensis	87.69	0.00e+00	1313.00
IUUC-Pva-103163	Pteropus vampyrus	88.79	0.00e+00	1630.00
IUUC-Rno-105766	Rattus norvegicus	89.70	0.00e+00	1615.00
IUUC-Sha-106610	Sarcophilus harrisii	81.01	0.00e+00	1478.00
IUUC-Sar-113256	Sorex araneus	90.09	1.00e-112	401.00
IUUC-Ssc-116353	Sus scrofa	96.03	0.00e+00	1729.00
IUUC-Tgu-116971	Taeniopygia guttata	77.33	0.00e+00	1380.00
IUUC-Tru-117932	Takifugu rubripes	46.82	2.00e-137	483.00
IUUC-Tsy-119185	Tarsius syrichta	87.99	0.00e+00	1108.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	4.00e-110	392.00
IUUC-Tbe-127281	Tupaia belangeri	82.52	0.00e+00	654.00
IUUC-Ttr-128177	Tursiops truncatus	96.94	0.00e+00	1378.00
IUUC-Vpa-130031	Vicugna pacos	96.13	0.00e+00	1805.00
IUUC-Xtr-132949	Xenopus tropicalis	65.35	0.00e+00	1160.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence