iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020835

UUCD1 version

UUC-CaF-00998

Ensembl Protein ID

ENSCAFP00000021817.3

UniProt Accession

E2RK09; F1PGV7; UBP37_CANLF

Protein Name

Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000014781.4	ENSCAFT00000023494.4	ENSCAFP00000021817.3
ENSCAFG00000014781.4	ENSCAFT00000023495.4	ENSCAFP00000021818.3
ENSCAFG00000014781.4	ENSCAFT00000023480.3	ENSCAFP00000021805.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-87	294.5	343	952

Active Site

Position(s)	Description	Evidence
352	Nucleophile	{ECO:0000250\|UniProtKB:Q86T82, ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
908	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e    +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 511
           ********************55.9999999999998899999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP++LilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppftlgwsahmaisrplkasqmvnscitspstpsknftfksksslalcldsdsedelkrsvalsqrlcemsgceqqqddlekd 684
           ***99*****************9999999999999999999999999999999999999999999999999999999999999999888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  skpcriepdkselensgfdgmseeellaavlemskreasptlshedddkptsspdtgfaeddiqempenqdpvetekpktvtepdpasf 773
           88888888888888888888888888888888888888888888888887777777777777777777777777777777777777766 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 774  teitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfldslgsd 857
           6666666655555550.....05555555555555555555556666666666666677777777777777777777888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++Y
   Q: 858  edsgnedvldmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSGY 946
           888888888888888888888999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 947  IFFYMH 952
           ****98 PP

Organism

Canis familiaris

Functional Description
(View)

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCTGTCAG GTGAATATTT TTGCTTTTTA ATTTGGCTAG AAGCAATTTA TTTTTAAAGA 60
ATGTCTCCTC TGAAGATACA CGGTCCTATC AGAATTCGAA GCATGCAGAC TGGAATTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0051301--P:cell division
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cfa:488523

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	98.98	0.00e+00	1818.00
IUUC-Apl-004033	Anas platyrhynchos	77.68	0.00e+00	1452.00
IUUC-Aca-005370	Anolis carolinensis	70.48	0.00e+00	1333.00
IUUC-Ame-011884	Astyanax mexicanus	58.03	0.00e+00	987.00
IUUC-Bta-012725	Bos taurus	96.12	0.00e+00	1746.00
IUUC-Cja-019939	Callithrix jacchus	95.51	0.00e+00	1698.00
IUUC-Cpo-022067	Cavia porcellus	94.34	0.00e+00	1584.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	7.00e-24	105.00
IUUC-Csa-023085	Chlorocebus sabaeus	96.02	0.00e+00	1773.00
IUUC-Cho-024390	Choloepus hoffmanni	87.68	3.00e-169	589.00
IUUC-Cin-025496	Ciona intestinalis	37.65	1.00e-43	171.00
IUUC-Csv-025812	Ciona savignyi	36.61	7.00e-42	165.00
IUUC-Dre-028255	Danio rerio	57.55	0.00e+00	952.00
IUUC-Dno-028986	Dasypus novemcinctus	95.42	0.00e+00	1727.00
IUUC-Dor-031062	Dipodomys ordii	80.00	0.00e+00	884.00
IUUC-Ete-032359	Echinops telfairi	83.57	0.00e+00	830.00
IUUC-Eca-033964	Equus caballus	95.92	0.00e+00	1771.00
IUUC-Eeu-034492	Erinaceus europaeus	86.93	0.00e+00	844.00
IUUC-Fca-036359	Felis catus	97.35	0.00e+00	1791.00
IUUC-Fal-037640	Ficedula albicollis	78.08	0.00e+00	1422.00
IUUC-Gmo-039600	Gadus morhua	54.20	0.00e+00	931.00
IUUC-Gga-040126	Gallus gallus	77.78	0.00e+00	1385.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.25	0.00e+00	922.00
IUUC-Ggo-045571	Gorilla gorilla	90.42	0.00e+00	1531.00
IUUC-Hsa-046043	Homo sapiens	94.80	0.00e+00	1722.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	93.88	0.00e+00	1706.00
IUUC-Lch-050357	Latimeria chalumnae	64.68	0.00e+00	1049.00
IUUC-Loc-052849	Lepisosteus oculatus	61.17	0.00e+00	1009.00
IUUC-Laf-054570	Loxodonta africana	94.30	0.00e+00	1684.00
IUUC-Mcc-054989	Macaca mulatta	95.74	0.00e+00	1635.00
IUUC-Meu-056273	Macropus eugenii	65.53	7.00e-175	607.00
IUUC-Mga-059814	Meleagris gallopavo	76.06	0.00e+00	1387.00
IUUC-Mmr-061726	Microcebus murinus	94.69	0.00e+00	1746.00
IUUC-Mdo-062974	Monodelphis domestica	85.22	0.00e+00	1585.00
IUUC-Mmu-064069	Mus musculus	90.31	0.00e+00	1625.00
IUUC-Mpu-066008	Mustela putorius furo	98.37	0.00e+00	1774.00
IUUC-Nle-069259	Nomascus leucogenys	95.82	0.00e+00	1726.00
IUUC-Opr-070882	Ochotona princeps	78.72	4.00e-141	495.00
IUUC-Ont-072441	Oreochromis niloticus	55.16	0.00e+00	934.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.62	2.00e-119	422.00
IUUC-Ocu-074879	Oryctolagus cuniculus	94.18	0.00e+00	1719.00
IUUC-Ola-087007	Oryzias latipes	53.74	0.00e+00	897.00
IUUC-Oga-088385	Otolemur garnettii	93.60	0.00e+00	1730.00
IUUC-Oar-090305	Ovis aries	96.12	0.00e+00	1776.00
IUUC-Ptr-091299	Pan troglodytes	95.51	0.00e+00	1728.00
IUUC-Pan-091996	Papio anubis	95.91	0.00e+00	1715.00
IUUC-Psi-093176	Pelodiscus sinensis	78.73	0.00e+00	1457.00
IUUC-Pma-094331	Petromyzon marinus	48.26	0.00e+00	758.00
IUUC-Pfo-096503	Poecilia formosa	56.69	0.00e+00	939.00
IUUC-Pab-098543	Pongo abelii	94.20	0.00e+00	918.00
IUUC-Pca-101099	Procavia capensis	88.16	0.00e+00	1320.00
IUUC-Pva-103163	Pteropus vampyrus	90.00	0.00e+00	1645.00
IUUC-Rno-105766	Rattus norvegicus	91.53	0.00e+00	1644.00
IUUC-Sha-106610	Sarcophilus harrisii	81.87	0.00e+00	1490.00
IUUC-Sar-113256	Sorex araneus	91.38	1.00e-114	407.00
IUUC-Ssc-116353	Sus scrofa	95.93	0.00e+00	1721.00
IUUC-Tgu-116971	Taeniopygia guttata	77.98	0.00e+00	1388.00
IUUC-Tru-117932	Takifugu rubripes	42.99	3.00e-180	625.00
IUUC-Tsy-119185	Tarsius syrichta	90.04	0.00e+00	1132.00
IUUC-Tni-119842	Tetraodon nigroviridis	59.81	3.00e-110	392.00
IUUC-Tbe-127281	Tupaia belangeri	84.38	0.00e+00	669.00
IUUC-Ttr-128177	Tursiops truncatus	96.94	0.00e+00	1372.00
IUUC-Vpa-130031	Vicugna pacos	96.53	0.00e+00	1806.00
IUUC-Xtr-132949	Xenopus tropicalis	65.16	0.00e+00	1165.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence