iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040126

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 37

Genbank Nucleotide ID

AADN04023947

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000011427.5	ENSGALT00000038204.3	ENSGALP00000037410.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.00e-83	279.2	343	959

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L++i++++++ll+   + ++++  k p ++l++ +++l+++    + + k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSIQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLAKKDvsSPEVKKELLKKVKSAISATAERFSGY 426
           69*****************************...*****9..689************99876677788888999*************** PP
   S: 88   eqqDaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           +q+Da+Efl+++ldql+e+++k +k+++ e   ++d+s    + + + +k +++++  +++++++++i+c++c+++ +++e+f+dls++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEKlNKTWKSEPVPNDDSSPGRASDDLSATKVYTCPVISNLEFEVQHSIICKTCGETVTKREQFNDLSID 515
           ********************7744555555555666666666688899999************************************** PP
   S: 176  vpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +p++++  ++ s+qd+L+ f+++ee+e    y+cekc++k+ a+ ++k+++lP+vLilhLkR+sf+ + + ++k+ ++v +p+ L+l +
   Q: 516  LPRRKKLFPSrSIQDSLDLFFRAEEIE----YSCEKCNGKS-AVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLS 599
           **9999876569**************9....********99.9********************************************** PP
   S: 264  fcts..................................................................................... 267
           +ct+                                                                                     
   Q: 600  HCTEstrlpltlgwsahsaisrplkasqmvnsctiststpcrkytfkskssaalyvdsdsddeplkrsvansqrlcniqcrdqqplqee 688
           **********************************************9999999999999999999999999999999999999999999 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 689  peksskrskmegdkpelgnagfdgmsedellaavleiskreaslslshdedkptsspdtgfgddeiqelpenletmetekpkaplesgp 777
           88888888888888888888888888888888888888888888888888887777777777777777777777777777777777777 PP
   S: 268  ......................................peekqke............................................ 274
                                                 +     e                                            
   Q: 778  anfteitkdfdenkenktpegsqgevdwlqqydmererE-----Eqelqqalaqslqeqeareqkedddlkratelslqefnsslldsv 861
           777777777766666666555555555555555555550.....055555666666666666666777777778888888888888888 PP
   S: 275  .................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
                                            +++Y+Li++v+H G ++ssGHY+++v++ k++ W++++D +V+ + e++v+ ++++
   Q: 862  gsdedsgnedvldmeyseaeaeelkrnaetgelPHSYRLISIVSHIGsTSSSGHYISDVYDIKKQsWFTYNDLEVSRTLETTVQCDRDR 950
           888888888888888888888899999999999****************************99889*********************** PP
   S: 329  taYvlfYkr 337
           ++Y++fY++
   Q: 951  SGYIFFYMH 959
           *******98 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAPLKVHGPV RMRSMQTGIT KWKEGSFEIV EKDNKVSLVV HYNVGGIPKT FQLSHNIKSV 60
TLRPNGRKLC CLMLTLKDTS FLTIDKVPLK DANEMRMYLD AVHQDRVHTA GKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGTGCGTC GCGCGGGGAG CCGGTTCCCG CCATCCGCCG CCGCGCCCCT CCGCGGGCCG 60
CAGGTACCGG GAGCGGCAGC CCTCCCCTCG GAGCGGGGCC TCCCTCAGCG GGGGGGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	77.27	0.00e+00	1390.00
IUUC-Apl-004033	Anas platyrhynchos	95.96	0.00e+00	1783.00
IUUC-Aca-005370	Anolis carolinensis	74.33	0.00e+00	1366.00
IUUC-Ame-011884	Astyanax mexicanus	58.07	0.00e+00	966.00
IUUC-Bta-012725	Bos taurus	76.70	0.00e+00	1367.00
IUUC-Cja-019939	Callithrix jacchus	77.35	0.00e+00	1343.00
IUUC-Cfa-020835	Canis familiaris	77.78	0.00e+00	1419.00
IUUC-Cpo-022067	Cavia porcellus	75.87	0.00e+00	1234.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.37	3.00e-24	106.00
IUUC-Csa-023085	Chlorocebus sabaeus	77.83	0.00e+00	1383.00
IUUC-Cho-024390	Choloepus hoffmanni	65.27	9.00e-128	451.00
IUUC-Cin-025496	Ciona intestinalis	37.07	7.00e-41	161.00
IUUC-Csv-025812	Ciona savignyi	35.09	9.00e-38	151.00
IUUC-Dre-028255	Danio rerio	57.40	0.00e+00	917.00
IUUC-Dno-028986	Dasypus novemcinctus	76.97	0.00e+00	1360.00
IUUC-Dor-031062	Dipodomys ordii	67.75	0.00e+00	715.00
IUUC-Ete-032359	Echinops telfairi	67.47	0.00e+00	639.00
IUUC-Eca-033964	Equus caballus	76.90	0.00e+00	1385.00
IUUC-Eeu-034492	Erinaceus europaeus	72.94	0.00e+00	671.00
IUUC-Fca-036359	Felis catus	77.45	0.00e+00	1398.00
IUUC-Fal-037640	Ficedula albicollis	95.14	0.00e+00	1786.00
IUUC-Gmo-039600	Gadus morhua	55.92	0.00e+00	912.00
IUUC-Gac-041557	Gasterosteus aculeatus	55.29	0.00e+00	875.00
IUUC-Ggo-045571	Gorilla gorilla	73.11	0.00e+00	1204.00
IUUC-Hsa-046043	Homo sapiens	76.87	0.00e+00	1357.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	76.39	0.00e+00	1352.00
IUUC-Lch-050357	Latimeria chalumnae	67.28	0.00e+00	1051.00
IUUC-Loc-052849	Lepisosteus oculatus	62.47	0.00e+00	1012.00
IUUC-Laf-054570	Loxodonta africana	76.62	0.00e+00	1347.00
IUUC-Mcc-054989	Macaca mulatta	77.05	0.00e+00	1263.00
IUUC-Meu-056273	Macropus eugenii	59.92	2.00e-157	550.00
IUUC-Mga-059814	Meleagris gallopavo	96.36	0.00e+00	1786.00
IUUC-Mmr-061726	Microcebus murinus	76.92	0.00e+00	1365.00
IUUC-Mdo-062974	Monodelphis domestica	80.91	0.00e+00	1478.00
IUUC-Mmu-064069	Mus musculus	74.97	0.00e+00	1301.00
IUUC-Mpu-066008	Mustela putorius furo	76.74	0.00e+00	1362.00
IUUC-Mlu-068224	Myotis lucifugus	38.12	5.00e-147	514.00
IUUC-Nle-069259	Nomascus leucogenys	77.20	0.00e+00	1358.00
IUUC-Opr-070882	Ochotona princeps	65.87	3.00e-106	379.00
IUUC-Ont-072441	Oreochromis niloticus	56.15	0.00e+00	903.00
IUUC-Oan-073151	Ornithorhynchus anatinus	81.67	1.00e-112	399.00
IUUC-Ocu-074879	Oryctolagus cuniculus	76.21	0.00e+00	1340.00
IUUC-Ola-087007	Oryzias latipes	54.62	0.00e+00	842.00
IUUC-Oga-088385	Otolemur garnettii	76.11	0.00e+00	1354.00
IUUC-Oar-090305	Ovis aries	76.60	0.00e+00	1390.00
IUUC-Ptr-091299	Pan troglodytes	76.69	0.00e+00	1355.00
IUUC-Pan-091996	Papio anubis	77.65	0.00e+00	1336.00
IUUC-Psi-093176	Pelodiscus sinensis	90.30	0.00e+00	1678.00
IUUC-Pma-094331	Petromyzon marinus	48.53	0.00e+00	734.00
IUUC-Ppa-095732	Physcomitrella patens	28.17	2.00e-21	97.10
IUUC-Pfo-096503	Poecilia formosa	55.72	0.00e+00	869.00
IUUC-Pab-098543	Pongo abelii	79.29	0.00e+00	754.00
IUUC-Pca-101099	Procavia capensis	72.39	0.00e+00	1064.00
IUUC-Pva-103163	Pteropus vampyrus	72.67	0.00e+00	1286.00
IUUC-Rno-105766	Rattus norvegicus	75.48	0.00e+00	1312.00
IUUC-Sha-106610	Sarcophilus harrisii	75.78	0.00e+00	1364.00
IUUC-Sar-113256	Sorex araneus	65.52	6.00e-85	308.00
IUUC-Ssc-116353	Sus scrofa	77.15	0.00e+00	1347.00
IUUC-Tgu-116971	Taeniopygia guttata	94.64	0.00e+00	1749.00
IUUC-Tru-117932	Takifugu rubripes	47.23	3.00e-134	472.00
IUUC-Tsy-119185	Tarsius syrichta	71.35	0.00e+00	873.00
IUUC-Tni-119842	Tetraodon nigroviridis	62.34	8.00e-110	390.00
IUUC-Tbe-127281	Tupaia belangeri	64.57	2.00e-150	526.00
IUUC-Ttr-128177	Tursiops truncatus	80.61	0.00e+00	1085.00
IUUC-Vpa-130031	Vicugna pacos	77.43	0.00e+00	1398.00
IUUC-Xtr-132949	Xenopus tropicalis	68.27	0.00e+00	1182.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence