iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000015218.3	ENSMMUT00000021337.3	ENSMMUP00000019955.3
ENSMMUG00000015218.3	ENSMMUT00000053751.1	ENSMMUP00000057414.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-69	234.8	343	907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e  + +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVSGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 511
           ********************55.9999999999999999999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppftlgwsahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrlcemsgneqqqedlekd 684
           ***999***************99999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  sklcpvepdrselensgfdrmseeellaavleiskrdaspslshedddkptsspdtgfaeddiqempenpdtmetekpktiteldpasf 773
           88888888888888888888888888888888888888877777777777777777777777777777777776666666666666666 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 774  teitkdcdenkenktP-----Egsqgeidwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfvdalgsd 857
           6666666655555550.....05555555555555555555666666666677777777777777777788888888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssG 293
                                         +++Y+Li+vv+H G ++ssG
   Q: 858  edsgnedvfdmeyteaeaeelkrnaetgslPHSYRLISVVSHIGsTSSSG 907
           888888888888888888999999999999**************888887 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLPAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGAGGGG CGGAGTTTTT GGCTGGCGCG CACGCGCCTG TCTGGTCGCG TAGAATGTGC 60
GTGCGTGCGT GCGTGTTTGC GTGTGGTCAC AGTTCCCGCC ATCAGCCGCT CTCCCTGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	95.31	0.00e+00	1616.00
IUUC-Apl-004033	Anas platyrhynchos	77.05	0.00e+00	1327.00
IUUC-Aca-005370	Anolis carolinensis	69.10	0.00e+00	1205.00
IUUC-Ame-011884	Astyanax mexicanus	56.52	0.00e+00	896.00
IUUC-Bta-012725	Bos taurus	94.30	0.00e+00	1583.00
IUUC-Cja-019939	Callithrix jacchus	96.98	0.00e+00	1588.00
IUUC-Cfa-020835	Canis familiaris	95.75	0.00e+00	1672.00
IUUC-Cpo-022067	Cavia porcellus	93.43	0.00e+00	1567.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.63	2.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	99.66	0.00e+00	1706.00
IUUC-Cho-024390	Choloepus hoffmanni	87.11	2.00e-167	583.00
IUUC-Cin-025496	Ciona intestinalis	37.65	3.00e-43	169.00
IUUC-Csv-025812	Ciona savignyi	36.22	1.00e-41	164.00
IUUC-Dre-028255	Danio rerio	56.05	0.00e+00	849.00
IUUC-Dno-028986	Dasypus novemcinctus	94.64	0.00e+00	1578.00
IUUC-Dor-031062	Dipodomys ordii	80.17	0.00e+00	890.00
IUUC-Ete-032359	Echinops telfairi	82.56	0.00e+00	820.00
IUUC-Eca-033964	Equus caballus	94.74	0.00e+00	1617.00
IUUC-Eeu-034492	Erinaceus europaeus	84.73	0.00e+00	697.00
IUUC-Fca-036359	Felis catus	94.85	0.00e+00	1608.00
IUUC-Fal-037640	Ficedula albicollis	77.27	0.00e+00	1298.00
IUUC-Gmo-039600	Gadus morhua	53.07	0.00e+00	834.00
IUUC-Gga-040126	Gallus gallus	77.05	0.00e+00	1259.00
IUUC-Gac-041557	Gasterosteus aculeatus	52.80	0.00e+00	820.00
IUUC-Ggo-045571	Gorilla gorilla	92.88	0.00e+00	1455.00
IUUC-Hsa-046043	Homo sapiens	97.76	0.00e+00	1647.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	92.95	0.00e+00	1562.00
IUUC-Lch-050357	Latimeria chalumnae	62.24	0.00e+00	956.00
IUUC-Loc-052849	Lepisosteus oculatus	59.98	0.00e+00	923.00
IUUC-Laf-054570	Loxodonta africana	92.41	0.00e+00	1524.00
IUUC-Meu-056273	Macropus eugenii	65.13	5.00e-173	601.00
IUUC-Mga-059814	Meleagris gallopavo	75.79	0.00e+00	1252.00
IUUC-Mmr-061726	Microcebus murinus	94.85	0.00e+00	1621.00
IUUC-Mdo-062974	Monodelphis domestica	84.35	0.00e+00	1451.00
IUUC-Mmu-064069	Mus musculus	90.04	0.00e+00	1498.00
IUUC-Mpu-066008	Mustela putorius furo	94.85	0.00e+00	1577.00
IUUC-Nle-069259	Nomascus leucogenys	98.88	0.00e+00	1652.00
IUUC-Opr-070882	Ochotona princeps	78.42	5.00e-141	495.00
IUUC-Ont-072441	Oreochromis niloticus	53.28	0.00e+00	831.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.98	6.00e-120	423.00
IUUC-Ocu-074879	Oryctolagus cuniculus	94.18	0.00e+00	1589.00
IUUC-Ola-087007	Oryzias latipes	51.89	0.00e+00	790.00
IUUC-Oga-088385	Otolemur garnettii	93.66	0.00e+00	1603.00
IUUC-Oar-090305	Ovis aries	93.85	0.00e+00	1610.00
IUUC-Ptr-091299	Pan troglodytes	98.55	0.00e+00	1654.00
IUUC-Pan-091996	Papio anubis	99.78	0.00e+00	1699.00
IUUC-Psi-093176	Pelodiscus sinensis	77.32	0.00e+00	1324.00
IUUC-Pma-094331	Petromyzon marinus	47.72	0.00e+00	680.00
IUUC-Ppa-095732	Physcomitrella patens	31.09	8.00e-25	108.00
IUUC-Pfo-096503	Poecilia formosa	54.02	0.00e+00	840.00
IUUC-Pab-098543	Pongo abelii	98.71	0.00e+00	835.00
IUUC-Pca-101099	Procavia capensis	88.65	0.00e+00	1212.00
IUUC-Pva-103163	Pteropus vampyrus	87.25	0.00e+00	1478.00
IUUC-Rno-105766	Rattus norvegicus	91.05	0.00e+00	1514.00
IUUC-Sha-106610	Sarcophilus harrisii	85.00	0.00e+00	1453.00
IUUC-Sar-113256	Sorex araneus	89.22	7.00e-112	398.00
IUUC-Ssc-116353	Sus scrofa	94.31	0.00e+00	1562.00
IUUC-Tgu-116971	Taeniopygia guttata	77.16	0.00e+00	1266.00
IUUC-Tru-117932	Takifugu rubripes	43.47	9.00e-169	587.00
IUUC-Tsy-119185	Tarsius syrichta	90.63	0.00e+00	1138.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	5.00e-111	395.00
IUUC-Tbe-127281	Tupaia belangeri	83.45	0.00e+00	661.00
IUUC-Ttr-128177	Tursiops truncatus	94.59	0.00e+00	1212.00
IUUC-Vpa-130031	Vicugna pacos	94.52	0.00e+00	1643.00
IUUC-Xtr-132949	Xenopus tropicalis	63.94	0.00e+00	1055.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence