iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090305

Ensembl Protein ID

ENSOARP00000021053.1

UniProt Accession

W5QEA5; W5QEA5_SHEEP

Genbank Protein ID

ENSOARP00000021053

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01056013

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000019601.1	ENSOART00000021347.1	ENSOARP00000021053.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-86	289.7	343	952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLVKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..679999999999999776567************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk+++ e    +++++d+   + ++ +++++ ++++++++++i+c+ c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKIEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKVCGEIIPKREQFNDLSIDL 511
           ********************55.8888888877777888888...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP++LilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppfnlgwsaqmavsrplkasqmvnscitspstpsknfsfksktslalcldsdsedelkrsvalsqrlcemsgseqqqeelekd 684
           ***99999999999999999999999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  skscriepdkselensgfdgmseeellaavleiskreaspslshedddkptsspdtgfaeddiqempenpdsvetekpktitepdpasf 773
           88888888888888888888877777777777777777777777777777777777777777777777777766666666666666666 PP
   S: 268  ...............peekqke................................................................... 274
                          p     e                                                                   
   Q: 774  teitkdcdenkenktP-----Egsqgevdwlqqydmerereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfldslgsd 857
           6666666655555550.....05555555555555555555666666666666666677777777777777777777888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e++v++++++++Y
   Q: 858  edsgnedvldmeyteseaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEASVQSDRDRSGY 946
           888888888888888888889999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 947  IFFYMH 952
           ****98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEVV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLNAA MKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTTTAGA ATCATGAAGG AAGGTAAAAG TTGGCCATAT TGCCATGGGC ACTCACACTG 60
AGAATGGAAT CTTTAGTATT CCTGATTGTC ATACAGTGAC AGCAGTATGG TTGTTAATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

oas:101110822

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	95.92	0.00e+00	1763.00
IUUC-Apl-004033	Anas platyrhynchos	77.13	0.00e+00	1439.00
IUUC-Aca-005370	Anolis carolinensis	69.63	0.00e+00	1315.00
IUUC-Ame-011884	Astyanax mexicanus	58.95	0.00e+00	993.00
IUUC-Bta-012725	Bos taurus	98.88	0.00e+00	1795.00
IUUC-Cja-019939	Callithrix jacchus	94.08	0.00e+00	1680.00
IUUC-Cfa-020835	Canis familiaris	96.12	0.00e+00	1816.00
IUUC-Cpo-022067	Cavia porcellus	92.41	0.00e+00	1559.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	1.00e-23	105.00
IUUC-Csa-023085	Chlorocebus sabaeus	93.99	0.00e+00	1747.00
IUUC-Cho-024390	Choloepus hoffmanni	85.71	8.00e-166	577.00
IUUC-Cin-025496	Ciona intestinalis	37.07	2.00e-43	171.00
IUUC-Csv-025812	Ciona savignyi	36.61	1.00e-41	164.00
IUUC-Dre-028255	Danio rerio	57.36	0.00e+00	946.00
IUUC-Dno-028986	Dasypus novemcinctus	93.88	0.00e+00	1705.00
IUUC-Dor-031062	Dipodomys ordii	78.61	0.00e+00	878.00
IUUC-Ete-032359	Echinops telfairi	81.95	0.00e+00	818.00
IUUC-Eca-033964	Equus caballus	95.01	0.00e+00	1752.00
IUUC-Eeu-034492	Erinaceus europaeus	86.05	0.00e+00	833.00
IUUC-Fca-036359	Felis catus	95.20	0.00e+00	1750.00
IUUC-Fal-037640	Ficedula albicollis	77.37	0.00e+00	1413.00
IUUC-Gmo-039600	Gadus morhua	54.71	0.00e+00	935.00
IUUC-Gga-040126	Gallus gallus	77.02	0.00e+00	1373.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.06	0.00e+00	918.00
IUUC-Ggo-045571	Gorilla gorilla	89.89	0.00e+00	1518.00
IUUC-Hsa-046043	Homo sapiens	93.78	0.00e+00	1701.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	92.76	0.00e+00	1682.00
IUUC-Lch-050357	Latimeria chalumnae	64.68	0.00e+00	1046.00
IUUC-Loc-052849	Lepisosteus oculatus	61.22	0.00e+00	1008.00
IUUC-Laf-054570	Loxodonta africana	92.98	0.00e+00	1666.00
IUUC-Mcc-054989	Macaca mulatta	93.84	0.00e+00	1613.00
IUUC-Meu-056273	Macropus eugenii	64.53	4.00e-172	598.00
IUUC-Mga-059814	Meleagris gallopavo	75.51	0.00e+00	1377.00
IUUC-Mmr-061726	Microcebus murinus	93.27	0.00e+00	1731.00
IUUC-Mdo-062974	Monodelphis domestica	84.26	0.00e+00	1568.00
IUUC-Mmu-064069	Mus musculus	88.38	0.00e+00	1599.00
IUUC-Mpu-066008	Mustela putorius furo	95.61	0.00e+00	1723.00
IUUC-Nle-069259	Nomascus leucogenys	93.99	0.00e+00	1702.00
IUUC-Opr-070882	Ochotona princeps	77.81	2.00e-139	490.00
IUUC-Ont-072441	Oreochromis niloticus	55.07	0.00e+00	932.00
IUUC-Oan-073151	Ornithorhynchus anatinus	82.07	5.00e-119	420.00
IUUC-Ocu-074879	Oryctolagus cuniculus	92.97	0.00e+00	1703.00
IUUC-Ola-087007	Oryzias latipes	54.69	0.00e+00	895.00
IUUC-Oga-088385	Otolemur garnettii	92.19	0.00e+00	1713.00
IUUC-Ptr-091299	Pan troglodytes	93.88	0.00e+00	1708.00
IUUC-Pan-091996	Papio anubis	94.12	0.00e+00	1693.00
IUUC-Psi-093176	Pelodiscus sinensis	78.28	0.00e+00	1446.00
IUUC-Pma-094331	Petromyzon marinus	47.71	0.00e+00	755.00
IUUC-Ppa-095732	Physcomitrella patens	30.38	3.00e-24	107.00
IUUC-Pfo-096503	Poecilia formosa	56.05	0.00e+00	932.00
IUUC-Pab-098543	Pongo abelii	93.28	0.00e+00	912.00
IUUC-Pca-101099	Procavia capensis	87.69	0.00e+00	1313.00
IUUC-Pva-103163	Pteropus vampyrus	88.79	0.00e+00	1629.00
IUUC-Rno-105766	Rattus norvegicus	89.50	0.00e+00	1614.00
IUUC-Sha-106610	Sarcophilus harrisii	80.61	0.00e+00	1474.00
IUUC-Sar-113256	Sorex araneus	89.66	2.00e-112	400.00
IUUC-Ssc-116353	Sus scrofa	95.63	0.00e+00	1723.00
IUUC-Tgu-116971	Taeniopygia guttata	77.23	0.00e+00	1379.00
IUUC-Tru-117932	Takifugu rubripes	46.82	3.00e-137	483.00
IUUC-Tsy-119185	Tarsius syrichta	87.70	0.00e+00	1108.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	5.00e-110	391.00
IUUC-Tbe-127281	Tupaia belangeri	82.28	0.00e+00	653.00
IUUC-Ttr-128177	Tursiops truncatus	96.68	0.00e+00	1377.00
IUUC-Vpa-130031	Vicugna pacos	95.92	0.00e+00	1801.00
IUUC-Xtr-132949	Xenopus tropicalis	65.45	0.00e+00	1161.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence