iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074879

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02042728

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012513.2	ENSOCUT00000012517.2	ENSOCUP00000010778.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-88	295.8	343	952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++ll+ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 343  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPFNALLRRFAHLLIKKDicNSETKKDLLKKVKNAISATAERFSGY 426
           69*****************************...*****9..689999999999999877677************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e    +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 427  MQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVPGEENSPDI---SATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 511
           ********************55.9999999999998899999...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 512  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSH 595
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 596  CTEntkppfalswsahmaisrplkasqmvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrfcemtsneqqqedlekd 684
           ***9********************99999999999999999999999999999999999999999999999999999888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 685  sklcriepdksemenagfdrmneeeliaavleiskretspspshedddkptsspdtgfaeddiqempenpdtietekpktatepdpasf 773
           88888888888887777777777777777777777777777777777777777777777777777776666666666666666666666 PP
   S: 268  ............peekqke...................................................................... 274
                       +     +                                                                      
   Q: 774  aeitkdcdenkeN-----Ktpegsqgevdwlqqydmerereeqelqqalvqslqeqeaweqkedddlkratelslqefnnsfldalgsd 857
           6666666555550.....05555555566666666666666666666777777777777777777777888888888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y
   Q: 858  edsgnedvfdmeytaaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQsWFTYNDLEVSKIQEAAVQSDRDRSGY 946
           888888888888888888899999999999****************************99889************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 947  IFFYMH 952
           ****98 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MSPLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLIV HYNTGGIPRT FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA IKPSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCCTC TGAAGATACA TGGTCCTATC AGAATTCGAA GTATGCAGAC TGGGATTACA 60
AAGTGGAAAG AAGGATCCTT TGAAATTGTG GAAAAAGAGA ATAAAGTCAG TCTAATAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100347231

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	93.78	0.00e+00	1736.00
IUUC-Apl-004033	Anas platyrhynchos	76.42	0.00e+00	1422.00
IUUC-Aca-005370	Anolis carolinensis	69.25	0.00e+00	1313.00
IUUC-Ame-011884	Astyanax mexicanus	57.08	0.00e+00	973.00
IUUC-Bta-012725	Bos taurus	92.86	0.00e+00	1699.00
IUUC-Cja-019939	Callithrix jacchus	94.49	0.00e+00	1691.00
IUUC-Cfa-020835	Canis familiaris	94.18	0.00e+00	1792.00
IUUC-Cpo-022067	Cavia porcellus	92.53	0.00e+00	1566.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	30.04	3.00e-24	107.00
IUUC-Csa-023085	Chlorocebus sabaeus	94.29	0.00e+00	1756.00
IUUC-Cho-024390	Choloepus hoffmanni	84.31	3.00e-165	575.00
IUUC-Cin-025496	Ciona intestinalis	38.43	7.00e-44	171.00
IUUC-Csv-025812	Ciona savignyi	36.61	4.00e-42	166.00
IUUC-Dre-028255	Danio rerio	56.73	0.00e+00	935.00
IUUC-Dno-028986	Dasypus novemcinctus	92.56	0.00e+00	1689.00
IUUC-Dor-031062	Dipodomys ordii	78.09	0.00e+00	879.00
IUUC-Ete-032359	Echinops telfairi	81.14	0.00e+00	813.00
IUUC-Eca-033964	Equus caballus	92.46	0.00e+00	1722.00
IUUC-Eeu-034492	Erinaceus europaeus	84.60	0.00e+00	818.00
IUUC-Fca-036359	Felis catus	93.27	0.00e+00	1727.00
IUUC-Fal-037640	Ficedula albicollis	76.52	0.00e+00	1394.00
IUUC-Gmo-039600	Gadus morhua	54.41	0.00e+00	929.00
IUUC-Gga-040126	Gallus gallus	76.32	0.00e+00	1355.00
IUUC-Gac-041557	Gasterosteus aculeatus	53.96	0.00e+00	915.00
IUUC-Ggo-045571	Gorilla gorilla	89.68	0.00e+00	1527.00
IUUC-Hsa-046043	Homo sapiens	93.78	0.00e+00	1712.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	91.95	0.00e+00	1682.00
IUUC-Lch-050357	Latimeria chalumnae	63.95	0.00e+00	1033.00
IUUC-Loc-052849	Lepisosteus oculatus	60.84	0.00e+00	997.00
IUUC-Laf-054570	Loxodonta africana	91.25	0.00e+00	1646.00
IUUC-Mcc-054989	Macaca mulatta	94.18	0.00e+00	1623.00
IUUC-Meu-056273	Macropus eugenii	64.13	2.00e-171	595.00
IUUC-Mga-059814	Meleagris gallopavo	74.70	0.00e+00	1361.00
IUUC-Mmr-061726	Microcebus murinus	93.88	0.00e+00	1744.00
IUUC-Mdo-062974	Monodelphis domestica	83.45	0.00e+00	1555.00
IUUC-Mmu-064069	Mus musculus	88.69	0.00e+00	1606.00
IUUC-Mpu-066008	Mustela putorius furo	93.27	0.00e+00	1694.00
IUUC-Nle-069259	Nomascus leucogenys	94.39	0.00e+00	1717.00
IUUC-Opr-070882	Ochotona princeps	79.94	9.00e-144	504.00
IUUC-Ont-072441	Oreochromis niloticus	54.36	0.00e+00	923.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.26	4.00e-119	421.00
IUUC-Ola-087007	Oryzias latipes	53.25	0.00e+00	885.00
IUUC-Oga-088385	Otolemur garnettii	93.10	0.00e+00	1730.00
IUUC-Oar-090305	Ovis aries	92.97	0.00e+00	1735.00
IUUC-Ptr-091299	Pan troglodytes	94.29	0.00e+00	1719.00
IUUC-Pan-091996	Papio anubis	94.44	0.00e+00	1703.00
IUUC-Psi-093176	Pelodiscus sinensis	77.58	0.00e+00	1432.00
IUUC-Pma-094331	Petromyzon marinus	48.16	0.00e+00	763.00
IUUC-Ppa-095732	Physcomitrella patens	29.75	3.00e-24	106.00
IUUC-Pfo-096503	Poecilia formosa	56.05	0.00e+00	931.00
IUUC-Pab-098543	Pongo abelii	93.83	0.00e+00	915.00
IUUC-Pca-101099	Procavia capensis	86.62	0.00e+00	1307.00
IUUC-Pva-103163	Pteropus vampyrus	86.44	0.00e+00	1596.00
IUUC-Rno-105766	Rattus norvegicus	89.70	0.00e+00	1625.00
IUUC-Sha-106610	Sarcophilus harrisii	80.30	0.00e+00	1463.00
IUUC-Sar-113256	Sorex araneus	87.93	3.00e-110	393.00
IUUC-Ssc-116353	Sus scrofa	92.98	0.00e+00	1686.00
IUUC-Tgu-116971	Taeniopygia guttata	76.11	0.00e+00	1356.00
IUUC-Tru-117932	Takifugu rubripes	46.31	2.00e-136	479.00
IUUC-Tsy-119185	Tarsius syrichta	89.02	0.00e+00	1123.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	4.00e-110	391.00
IUUC-Tbe-127281	Tupaia belangeri	81.82	0.00e+00	655.00
IUUC-Ttr-128177	Tursiops truncatus	93.22	0.00e+00	1333.00
IUUC-Vpa-130031	Vicugna pacos	93.07	0.00e+00	1759.00
IUUC-Xtr-132949	Xenopus tropicalis	65.05	0.00e+00	1159.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence