iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088385

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03031329

Gene Name

USP37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004165.2	ENSOGAT00000004174.2	ENSOGAP00000003723.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-87	293.6	348	957

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 348  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QGIPWK--KIPLNALIRRFAHLLIKKDicNSETKKDLLKKVKNAISATAERFSGY 431
           69*****************************...*****9..68999******9999887677************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e+++k  nk++++e    +++++d+   + ++ +++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 432  MQNDAHEFLSQCLDQLKEDMDK-LNKTWKTEPFPGEENSPDI---SVTRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 516
           ********************66.6777777666666677887...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+++lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 517  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 600
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 601  CTEntkppftlgwnahmaisrplkasqtvnscitspstpskkftfksksslalcldsdsedelkrsvalsqrfcdmsgneqqqevlekd 689
           ***9******************9999999999999999999999999999999999999999999999999999999988888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 690  sklcqiepdkselensgfdkmseeelltavleiskretlpslshedddkptsspdtgfaeddmqemsenpdtmeseksktiiepdpasf 778
           88888888888888888888888888888888888888888877777777777777777777777777777776666666666666666 PP
   S: 268  .............peekqke..................................................................... 274
                        +     +                                                                     
   Q: 779  teiakdcdenkenK-----Tpevsqgevdwlqqydmdrereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfldalgsd 862
           66666665555550.....0555555555555555555566666666666666667777777777777777888888888888888888 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y
   Q: 863  edsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRSGY 951
           888888888888888888889999999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 952  IFFYMH 957
           ****98 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSSLKIHGPI RIRSMQTGIT KWKEGSFEIV EKENKVSLVV HYNTGGIPRI FQLSHNIKNV 60
VLRPSGAKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA ATKPSQGSGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTTCCT TAGAACCTAT CCGGTGAAGG TATATTTTTG CTTTTTAATT TGGGTAGAAG 60
CAATTTATTT TTAAAGAAAA TATGTCTTCT CTGAAGATAC ATGGTCCTAT CAGAATTCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	93.20	0.00e+00	1726.00
IUUC-Apl-004033	Anas platyrhynchos	76.31	0.00e+00	1431.00
IUUC-Aca-005370	Anolis carolinensis	68.86	0.00e+00	1310.00
IUUC-Ame-011884	Astyanax mexicanus	57.41	0.00e+00	987.00
IUUC-Bta-012725	Bos taurus	92.19	0.00e+00	1694.00
IUUC-Cja-019939	Callithrix jacchus	92.28	0.00e+00	1672.00
IUUC-Cfa-020835	Canis familiaris	93.60	0.00e+00	1779.00
IUUC-Cpo-022067	Cavia porcellus	92.12	0.00e+00	1561.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	3.00e-23	103.00
IUUC-Csa-023085	Chlorocebus sabaeus	94.02	0.00e+00	1752.00
IUUC-Cho-024390	Choloepus hoffmanni	81.49	6.00e-165	574.00
IUUC-Cin-025496	Ciona intestinalis	37.65	3.00e-43	169.00
IUUC-Csv-025812	Ciona savignyi	36.22	2.00e-41	164.00
IUUC-Dre-028255	Danio rerio	56.36	0.00e+00	947.00
IUUC-Dno-028986	Dasypus novemcinctus	91.48	0.00e+00	1675.00
IUUC-Dor-031062	Dipodomys ordii	77.91	0.00e+00	878.00
IUUC-Ete-032359	Echinops telfairi	81.53	0.00e+00	825.00
IUUC-Eca-033964	Equus caballus	92.09	0.00e+00	1720.00
IUUC-Eeu-034492	Erinaceus europaeus	85.14	0.00e+00	819.00
IUUC-Fca-036359	Felis catus	92.08	0.00e+00	1721.00
IUUC-Fal-037640	Ficedula albicollis	76.81	0.00e+00	1410.00
IUUC-Gmo-039600	Gadus morhua	53.43	0.00e+00	931.00
IUUC-Gga-040126	Gallus gallus	76.11	0.00e+00	1360.00
IUUC-Gac-041557	Gasterosteus aculeatus	52.98	0.00e+00	902.00
IUUC-Ggo-045571	Gorilla gorilla	88.33	0.00e+00	1531.00
IUUC-Hsa-046043	Homo sapiens	92.49	0.00e+00	1705.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	92.09	0.00e+00	1676.00
IUUC-Lch-050357	Latimeria chalumnae	63.56	0.00e+00	1026.00
IUUC-Loc-052849	Lepisosteus oculatus	61.37	0.00e+00	1014.00
IUUC-Laf-054570	Loxodonta africana	90.28	0.00e+00	1639.00
IUUC-Mcc-054989	Macaca mulatta	93.65	0.00e+00	1615.00
IUUC-Meu-056273	Macropus eugenii	63.62	1.00e-171	596.00
IUUC-Mga-059814	Meleagris gallopavo	74.40	0.00e+00	1360.00
IUUC-Mmr-061726	Microcebus murinus	95.33	0.00e+00	1778.00
IUUC-Mdo-062974	Monodelphis domestica	82.95	0.00e+00	1561.00
IUUC-Mmu-064069	Mus musculus	88.44	0.00e+00	1616.00
IUUC-Mpu-066008	Mustela putorius furo	92.59	0.00e+00	1685.00
IUUC-Nle-069259	Nomascus leucogenys	93.00	0.00e+00	1706.00
IUUC-Opr-070882	Ochotona princeps	78.12	4.00e-140	492.00
IUUC-Ont-072441	Oreochromis niloticus	53.78	0.00e+00	930.00
IUUC-Oan-073151	Ornithorhynchus anatinus	76.98	8.00e-124	436.00
IUUC-Ocu-074879	Oryctolagus cuniculus	92.39	0.00e+00	1704.00
IUUC-Ola-087007	Oryzias latipes	53.18	0.00e+00	889.00
IUUC-Oar-090305	Ovis aries	91.38	0.00e+00	1720.00
IUUC-Ptr-091299	Pan troglodytes	93.61	0.00e+00	1710.00
IUUC-Pan-091996	Papio anubis	94.05	0.00e+00	1697.00
IUUC-Psi-093176	Pelodiscus sinensis	77.67	0.00e+00	1436.00
IUUC-Pma-094331	Petromyzon marinus	48.42	0.00e+00	772.00
IUUC-Pfo-096503	Poecilia formosa	55.27	0.00e+00	921.00
IUUC-Pab-098543	Pongo abelii	93.47	0.00e+00	909.00
IUUC-Pca-101099	Procavia capensis	85.49	0.00e+00	1293.00
IUUC-Pva-103163	Pteropus vampyrus	85.90	0.00e+00	1586.00
IUUC-Rno-105766	Rattus norvegicus	89.45	0.00e+00	1620.00
IUUC-Sha-106610	Sarcophilus harrisii	80.44	0.00e+00	1470.00
IUUC-Sar-113256	Sorex araneus	88.46	4.00e-110	392.00
IUUC-Ssc-116353	Sus scrofa	92.50	0.00e+00	1681.00
IUUC-Tgu-116971	Taeniopygia guttata	76.61	0.00e+00	1374.00
IUUC-Tru-117932	Takifugu rubripes	44.85	0.00e+00	651.00
IUUC-Tsy-119185	Tarsius syrichta	86.92	0.00e+00	1119.00
IUUC-Tni-119842	Tetraodon nigroviridis	60.13	4.00e-112	398.00
IUUC-Tbe-127281	Tupaia belangeri	79.95	0.00e+00	662.00
IUUC-Ttr-128177	Tursiops truncatus	93.22	0.00e+00	1342.00
IUUC-Vpa-130031	Vicugna pacos	93.00	0.00e+00	1761.00
IUUC-Xtr-132949	Xenopus tropicalis	64.69	0.00e+00	1167.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence