iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000016831.1	ENSONIT00000021226.1	ENSONIP00000021207.1
ENSONIG00000016831.1	ENSONIT00000021227.1	ENSONIP00000021208.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.30e-85	285.3	316	930
UBD/Alpha-Helix/UIM	1.40e-07	31.1	787	804

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++p++ +++l+   +++++++   p ++ll+ +++l+ +      ++k+   r++++a++++ae+fsg+
   Q: 316  QGFSNLGNTCYMNAILQSLFSLPSFSNDMLR---QSIPWKK--LPINALLRRFAHLMVKKDvaCPETKKDLLRKVKSAISSTAERFSGN 399
           69*****************************...9***984..56667777777776555466788899999***************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde...................aeekkkkknkslisdlFqgqlksqikcl 157
           +q+Da+Efl+++ldql+++++k +++ ++e+  +++s    +                    e ++ + +++++  +++++++++i+c+
   Q: 400  MQNDAHEFLSQCLDQLKDDVEKMNKSLTNEAAASSSS----SvvgengleatssavkaepgDEADTSRIYTCPVAVNMEFEVQHTITCK 484
           ********************66333333333333322....134668999999999999988888999999****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqks 245
            c++v +++e+f+dls+++p++++t ++ s+qd+L+ f++ ee+e    y+cekc++k+ a+ ++k++klP+vLilhLkR+sf+ + + 
   Q: 485  GCGEVVTKREQFNDLSIDLPRRKKTLPLrSIQDSLDLFFRMEEIE----YSCEKCNGKS-ATVTHKFSKLPRVLILHLKRYSFNAQLSL 568
           ********************999887645***************9....********99.9**************************** PP
   S: 246  rekinkkvefpleLdlspfcts................................................................... 267
           ++k+ ++v +p+ L+l p+ct+                                                                   
   Q: 569  NSKLGQQVLIPRYLTLLPHCTEstrppislgwspqaalsrtlktsqsvnsstgplrrivgktsnsnctsilvdsdceegpnrkvsasrk 657
           **********************9****************99999999999999999999999999999999999999999999999999 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 658  rrlsiclpddddraeergaaidstdfsginddemlaavleisrqeaglsappslddeptsspdtgfgdtdahdlayhadlleadskqpa 746
           99999999999998888888888888888888888888888888888888888888888888888888888888888888888888888 PP
   S: 268  ...............................peekqke................................................... 274
                                          +     +                                                   
   Q: 747  dvldsldltmdenkenqtpesgqqqgeldwvQ-----Qynldqereeqelqqalaqslqeheaqemredddlkratelslqefnnslpd 830
           88888888777776666655555555555550.....0555555555556666666666666777777777777777777778888888 PP
   S: 275  ...................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleet 326
                                               ++++Li+vv+H G s+ssGHY+++v++ k++ Wl+++D  V+ ++e+ v++++
   Q: 831  llcsdddsgnedvldmeyteaeaenlkrnaesgelANSFRLISVVSHIGsSSSSGHYISDVYDMKKQsWLTYNDLDVSRTQEAAVQRDR 919
           88888888888888888888888888889999999****************************88888********************* PP
   S: 327  gstaYvlfYkr 337
           ++++Y++fY++
   Q: 920  DRSGYIFFYMH 930
           *********98 PP

UBD/Alpha-Helix/UIM

   S: 2    EdeeLqlAlalSlqEeee 19
           E++eLq+Ala+SlqE+e 
   Q: 787  EEQELQQALAQSLQEHEA 804
           9***************95 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MATVVPKVSS GGAVKIRFTS LDLGTTRWKE GTFEILEKDN KVNLCLRFNC GGASKTFQLN 60
QNVKNISQNV NRIVLTLKDN SVITLDRMPQ PLVQKTKEYL EKLKQGKPVL KSSLGSANFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTAGTTTG AGTCCCAGTC TCCCAAGTGC ACCAACGGGA TAGCAAGCCA TGGCAACTGT 60
AGTGCCCAAA GTCTCCAGCG GTGGGGCTGT GAAGATCCGT TTCACCAGTC TGGACCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	54.50	0.00e+00	913.00
IUUC-Apl-004033	Anas platyrhynchos	56.22	0.00e+00	942.00
IUUC-Aca-005370	Anolis carolinensis	54.30	0.00e+00	900.00
IUUC-Ame-011884	Astyanax mexicanus	73.99	0.00e+00	1303.00
IUUC-Bta-012725	Bos taurus	54.55	0.00e+00	903.00
IUUC-Cja-019939	Callithrix jacchus	54.46	0.00e+00	901.00
IUUC-Cfa-020835	Canis familiaris	55.16	0.00e+00	934.00
IUUC-Cpo-022067	Cavia porcellus	53.86	0.00e+00	825.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.17	7.00e-25	109.00
IUUC-Csa-023085	Chlorocebus sabaeus	54.60	0.00e+00	921.00
IUUC-Cho-024390	Choloepus hoffmanni	51.68	2.00e-63	238.00
IUUC-Cin-025496	Ciona intestinalis	33.07	2.00e-46	181.00
IUUC-Csv-025812	Ciona savignyi	32.55	6.00e-41	162.00
IUUC-Dre-028255	Danio rerio	70.99	0.00e+00	1238.00
IUUC-Dno-028986	Dasypus novemcinctus	53.51	0.00e+00	894.00
IUUC-Dor-031062	Dipodomys ordii	43.93	3.00e-125	442.00
IUUC-Ete-032359	Echinops telfairi	48.82	3.00e-123	436.00
IUUC-Eca-033964	Equus caballus	54.55	0.00e+00	913.00
IUUC-Eeu-034492	Erinaceus europaeus	50.95	1.00e-119	424.00
IUUC-Fca-036359	Felis catus	55.41	0.00e+00	924.00
IUUC-Fal-037640	Ficedula albicollis	56.99	0.00e+00	920.00
IUUC-Gmo-039600	Gadus morhua	80.00	0.00e+00	1424.00
IUUC-Gga-040126	Gallus gallus	55.52	0.00e+00	882.00
IUUC-Gac-041557	Gasterosteus aculeatus	84.47	0.00e+00	1491.00
IUUC-Ggo-045571	Gorilla gorilla	51.15	0.00e+00	795.00
IUUC-Hsa-046043	Homo sapiens	54.00	0.00e+00	907.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	55.12	0.00e+00	908.00
IUUC-Lch-050357	Latimeria chalumnae	52.94	0.00e+00	778.00
IUUC-Loc-052849	Lepisosteus oculatus	70.59	0.00e+00	1171.00
IUUC-Laf-054570	Loxodonta africana	53.23	0.00e+00	883.00
IUUC-Mcc-054989	Macaca mulatta	53.17	0.00e+00	827.00
IUUC-Meu-056273	Macropus eugenii	44.84	3.00e-41	164.00
IUUC-Mga-059814	Meleagris gallopavo	54.03	0.00e+00	868.00
IUUC-Mmr-061726	Microcebus murinus	54.55	0.00e+00	915.00
IUUC-Mdo-062974	Monodelphis domestica	56.51	0.00e+00	948.00
IUUC-Mmu-064069	Mus musculus	54.40	0.00e+00	902.00
IUUC-Mpu-066008	Mustela putorius furo	54.66	0.00e+00	916.00
IUUC-Mlu-068224	Myotis lucifugus	32.30	5.00e-104	372.00
IUUC-Nle-069259	Nomascus leucogenys	53.80	0.00e+00	903.00
IUUC-Opr-070882	Ochotona princeps	69.10	3.00e-86	313.00
IUUC-Oan-073151	Ornithorhynchus anatinus	60.90	3.00e-90	325.00
IUUC-Ocu-074879	Oryctolagus cuniculus	54.35	0.00e+00	895.00
IUUC-Ola-087007	Oryzias latipes	79.94	0.00e+00	1385.00
IUUC-Oga-088385	Otolemur garnettii	53.57	0.00e+00	912.00
IUUC-Oar-090305	Ovis aries	54.55	0.00e+00	912.00
IUUC-Ptr-091299	Pan troglodytes	54.01	0.00e+00	905.00
IUUC-Pan-091996	Papio anubis	55.34	0.00e+00	899.00
IUUC-Psi-093176	Pelodiscus sinensis	57.01	0.00e+00	950.00
IUUC-Pma-094331	Petromyzon marinus	44.14	0.00e+00	643.00
IUUC-Ppa-095685	Physcomitrella patens	26.59	1.00e-23	105.00
IUUC-Pfo-096503	Poecilia formosa	84.70	0.00e+00	1458.00
IUUC-Pab-098543	Pongo abelii	57.44	2.00e-151	529.00
IUUC-Pca-101099	Procavia capensis	54.29	0.00e+00	727.00
IUUC-Pva-103163	Pteropus vampyrus	52.81	2.00e-176	613.00
IUUC-Rno-105766	Rattus norvegicus	53.70	0.00e+00	886.00
IUUC-Sha-106610	Sarcophilus harrisii	52.95	0.00e+00	846.00
IUUC-Sar-113624	Sorex araneus	44.81	8.00e-55	209.00
IUUC-Ssc-116353	Sus scrofa	53.91	0.00e+00	894.00
IUUC-Tgu-116971	Taeniopygia guttata	57.31	0.00e+00	901.00
IUUC-Tru-117932	Takifugu rubripes	56.88	0.00e+00	915.00
IUUC-Tsy-119185	Tarsius syrichta	55.12	1.00e-178	620.00
IUUC-Tni-119842	Tetraodon nigroviridis	69.86	2.00e-136	479.00
IUUC-Tbe-127281	Tupaia belangeri	41.75	2.00e-76	281.00
IUUC-Ttr-128177	Tursiops truncatus	59.72	0.00e+00	781.00
IUUC-Vpa-130031	Vicugna pacos	54.86	0.00e+00	917.00
IUUC-Xtr-132949	Xenopus tropicalis	54.52	0.00e+00	875.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence