iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-88	296.5	341	950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   ++++++  k p ++l++ +++l+ +    +s++k+   +++++a++++ae+fsgy
   Q: 341  QGFSNLGNTCYMNAILQSLFSLQSFANDLLK---QSIPWK--KIPLNALIRRFANLLIKKDisNSETKKELLKKVKNAISATAERFSGY 424
           69*****************************...*****9..68***********9988767799************************ PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
            q+Da+Efl+++ldql+e+++k  nk++++e    +++++d    + +k  ++++ ++++++++++i+c++c+++  ++e+f+dls+++
   Q: 425  VQNDAHEFLSQCLDQLKEDMEK-LNKTWKTEPVLGEENSPDT---SATKVFTCPVITNLEFEVQHSIICKACGETIPKREQFNDLSIDL 509
           ********************55.8888888888887777776...7999**************************************** PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++  ++ s+qd+L+ f+++eele    y+cekc +k+ a  ++k+ +lP+vLilhLkR+sf+ + + ++ki ++v +p+ L+ls++
   Q: 510  PRRKKPLPPrSIQDSLDLFFRAEELE----YSCEKCGGKC-ALVRHKFIRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 593
           *999886545***************9....*********9.89999******************************************* PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 594  CTEntkppftlgwsahmaisrplracqmvnscitspsapskkftfkskssltscldsdsedelkrsvalsqrlcdlpgneqyqedvekd 682
           ***99999999999999999999999999999999999999999999999999999999999999999999999999999999998888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 683  lklcrldpgkselensgfdrmseeevlaavleisrreaspvlspedddkptsspdtgfaeddipempenpdameiekpkaitepgpasf 771
           88888888888888888888888888888888888888888888888888888777777777777777777777777777777777777 PP
   S: 268  ................................peekqke.................................................. 274
                                           +     e                                                  
   Q: 772  teitkdcdenkenktpegsqgevdwlqqydieR-----Ereeqelqqalaqslqeqeaweqkedddlkratelslqefnnsfldslgsd 855
           777777766666655555555555555555550.....055555556666666666666666677777777777777777777777777 PP
   S: 275  ..............................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaY 331
                                         +++Y+Li+vv+H G ++ssGHY+++v++ k++ W++++D +V++++e+ v++++++++Y
   Q: 856  edsgnedvfdmeyteaeaeelkrnaetgnlPHSYRLISVVSHIGsTSSSGHYISDVYDIKKQaWFTYNDLEVSKIQEAAVQSDRDRSGY 944
           778888888888888888888889999999****************************99999************************** PP
   S: 332  vlfYkr 337
           ++fY++
   Q: 945  IFFYMH 950
           ****98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSPLKIYGPI RIRSMQTGIT KWKEGSFEIV DKDSKVSLVV HYNTGGIPRV FQLSHNIKNV 60
VLRPSGTKQS RLMLTLQDNS FLSIDKVPSK DAEEMRLFLD AVHQNRLHAA MKSSQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATTAATCA CTTGTAATTT TTTTTCTTTA GAATTCGTCA GGTGAACATA TATTTTTGCT 60
TTTTAATTTG GTTAAAAGCA ATTTATTTTT AAAGAAAATA TGTCTCCTCT GAAGATATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006275--P:regulation of DNA replication
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:100361658

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	91.53	0.00e+00	1685.00
IUUC-Apl-004033	Anas platyrhynchos	76.32	0.00e+00	1410.00
IUUC-Aca-005370	Anolis carolinensis	69.33	0.00e+00	1310.00
IUUC-Ame-011884	Astyanax mexicanus	57.03	0.00e+00	967.00
IUUC-Bta-012725	Bos taurus	89.91	0.00e+00	1637.00
IUUC-Cja-019939	Callithrix jacchus	91.02	0.00e+00	1620.00
IUUC-Cfa-020835	Canis familiaris	91.73	0.00e+00	1728.00
IUUC-Cpo-022067	Cavia porcellus	89.24	0.00e+00	1501.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	29.22	2.00e-22	101.00
IUUC-Csa-023085	Chlorocebus sabaeus	91.54	0.00e+00	1694.00
IUUC-Cho-024390	Choloepus hoffmanni	82.87	1.00e-162	567.00
IUUC-Cin-025496	Ciona intestinalis	37.45	5.00e-44	172.00
IUUC-Csv-025812	Ciona savignyi	36.61	1.00e-42	167.00
IUUC-Dre-028255	Danio rerio	56.57	0.00e+00	923.00
IUUC-Dno-028986	Dasypus novemcinctus	90.40	0.00e+00	1632.00
IUUC-Dor-031062	Dipodomys ordii	76.00	0.00e+00	857.00
IUUC-Ete-032359	Echinops telfairi	78.30	0.00e+00	780.00
IUUC-Eca-033964	Equus caballus	90.83	0.00e+00	1679.00
IUUC-Eeu-034492	Erinaceus europaeus	82.97	0.00e+00	792.00
IUUC-Fca-036359	Felis catus	90.61	0.00e+00	1662.00
IUUC-Fal-037640	Ficedula albicollis	75.68	0.00e+00	1368.00
IUUC-Gmo-039600	Gadus morhua	53.55	0.00e+00	910.00
IUUC-Gga-040126	Gallus gallus	75.58	0.00e+00	1337.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.05	0.00e+00	902.00
IUUC-Ggo-045571	Gorilla gorilla	86.99	0.00e+00	1476.00
IUUC-Hsa-046043	Homo sapiens	90.71	0.00e+00	1649.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	89.59	0.00e+00	1638.00
IUUC-Lch-050357	Latimeria chalumnae	63.37	0.00e+00	1008.00
IUUC-Loc-052849	Lepisosteus oculatus	59.53	0.00e+00	972.00
IUUC-Laf-054570	Loxodonta africana	88.91	0.00e+00	1592.00
IUUC-Mcc-054989	Macaca mulatta	91.27	0.00e+00	1561.00
IUUC-Meu-056273	Macropus eugenii	61.92	2.00e-162	566.00
IUUC-Mga-059814	Meleagris gallopavo	74.49	0.00e+00	1343.00
IUUC-Mmr-061726	Microcebus murinus	90.72	0.00e+00	1675.00
IUUC-Mdo-062974	Monodelphis domestica	82.57	0.00e+00	1525.00
IUUC-Mmu-064069	Mus musculus	96.02	0.00e+00	1741.00
IUUC-Mpu-066008	Mustela putorius furo	91.32	0.00e+00	1652.00
IUUC-Mlu-068224	Myotis lucifugus	40.49	2.00e-157	550.00
IUUC-Nle-069259	Nomascus leucogenys	91.74	0.00e+00	1656.00
IUUC-Opr-070882	Ochotona princeps	92.52	6.00e-110	392.00
IUUC-Ont-072441	Oreochromis niloticus	54.48	0.00e+00	917.00
IUUC-Oan-073151	Ornithorhynchus anatinus	79.68	4.00e-117	414.00
IUUC-Ocu-074879	Oryctolagus cuniculus	89.91	0.00e+00	1642.00
IUUC-Ola-087007	Oryzias latipes	53.74	0.00e+00	879.00
IUUC-Oga-088385	Otolemur garnettii	89.96	0.00e+00	1660.00
IUUC-Oar-090305	Ovis aries	89.70	0.00e+00	1659.00
IUUC-Ptr-091299	Pan troglodytes	91.44	0.00e+00	1657.00
IUUC-Pan-091996	Papio anubis	91.70	0.00e+00	1650.00
IUUC-Psi-093176	Pelodiscus sinensis	76.32	0.00e+00	1406.00
IUUC-Pma-094331	Petromyzon marinus	48.26	0.00e+00	768.00
IUUC-Ppa-095732	Physcomitrella patens	30.16	6.00e-26	112.00
IUUC-Pfo-096503	Poecilia formosa	55.37	0.00e+00	903.00
IUUC-Pab-098543	Pongo abelii	91.65	0.00e+00	889.00
IUUC-Pca-101099	Procavia capensis	83.03	0.00e+00	1235.00
IUUC-Pva-103163	Pteropus vampyrus	84.61	0.00e+00	1551.00
IUUC-Sha-106610	Sarcophilus harrisii	79.23	0.00e+00	1433.00
IUUC-Sar-113256	Sorex araneus	87.93	1.00e-109	391.00
IUUC-Ssc-116353	Sus scrofa	90.84	0.00e+00	1630.00
IUUC-Tgu-116971	Taeniopygia guttata	75.58	0.00e+00	1340.00
IUUC-Tru-117932	Takifugu rubripes	46.03	1.00e-134	474.00
IUUC-Tsy-119185	Tarsius syrichta	86.49	0.00e+00	1097.00
IUUC-Tni-119842	Tetraodon nigroviridis	58.82	9.00e-110	390.00
IUUC-Tbe-127281	Tupaia belangeri	79.02	0.00e+00	629.00
IUUC-Ttr-128177	Tursiops truncatus	91.22	0.00e+00	1298.00
IUUC-Vpa-130031	Vicugna pacos	90.62	0.00e+00	1697.00
IUUC-Xtr-132949	Xenopus tropicalis	63.60	0.00e+00	1130.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence