iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132949

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-specific peptidase 37

Genbank Nucleotide ID

AAMC01028420

Gene Name

usp37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000014977.3	ENSXETT00000032749.3	ENSXETP00000032749.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-81	274.3	341	959
UBD/Alpha-Helix/UIM	3.40e-06	26.7	837	854

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +G++NlgNtCYmN++LQ+L+++++++++ll+   + ++ +  k p+++l++ +++l+++    + + k+   +++++a++++ae+fsgy
   Q: 341  QGFSNLGNTCYMNAILQSLFSLQPFAHDLLK---QGIPYR--KIPTNALIRRFAHLLAKKDicSPEVKKDLLKKVKSAISATAERFSGY 424
           69*****************************...999988..68*************9987779999999******************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +q+Da+Efl+++ldql+e++ k +++ k+e+++ d+    + +++  ++ ++++++ +F+++++++i+c+ c+++ +++e+f+dls+++
   Q: 425  MQNDAHEFLSQCLDQLKEDMGKLNKTWKTELSSGDDVPGVKANDDLSTRIYTCPVTCNFEFEVQHSIICKICGETVNKREQFNDLSIDL 513
           ********************886666667777778888888899********************************************* PP
   S: 177  pgkeetkke.slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           p++++ +++ s+qd+L+ f++ e le    y cekc +k+ a+ ++k+++lP++LilhLkR+sf+   + ++k+ ++v +p+ L+ls++
   Q: 514  PRRKKPSPSrSIQDSLDLFFRLEDLE----YACEKCSGKS-ATVMHKFSRLPRILILHLKRYSFNVILSLNNKVGQQVVIPRYLTLSSH 597
           ***99987669**************9....********99.9*********************************************** PP
   S: 265  cts...................................................................................... 267
           ct+                                                                                      
   Q: 598  CTEstrtplslgwnaqtalnarplklsqmvnsctmststplrkqmfkaanslpvcldsesddeqikrcvshsqricdmelkeqqcedkd 686
           ***99999999999999999999999999999999999999999999999999999999999999999999999999998888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 687  knsllakkeaskcletgdacfdemnddelvaavlemskketslseshddedklssspdtgfggdddvqeiaenhepmeeervktsiltn 775
           88888888888888888888888888888888888887777777777777777777777777777777777777777666666666666 PP
   S: 268  .....................peekqke............................................................. 274
                                p     e                                                             
   Q: 776  lgvlqysdmakdfdenkenktP-----Easqndvdwlqydlerereeqelqqalaqslqeqearemkedddlkratelslqefnntlmd 859
           6666666666666666555550.....05555555555555555555566666666666666777777777777777777777778888 PP
   S: 275  ...................................kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleet 326
                                              +++Y+Li+vv+H G s+ssGHY+++v++ +++ W++++D +V+ ++e++v++++
   Q: 860  gmvsdedsgneevldmeyseaeteelkknaetgdlPHSYRLISVVSHIGsSSSSGHYISDVYDVRKQaWFTYNDLEVSRTQETTVQSDR 948
           88888888888888888888888888999999999****************************88888********************* PP
   S: 327  gstaYvlfYkr 337
           ++++Y++fY++
   Q: 949  DRSGYIFFYMH 959
           *********98 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEee 18
           +Ed++L +A +lSlqE +
   Q: 837  KEDDDLKRATELSLQEFN 854
           69**************76 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MALHSLHGPI RIHCLKVGTS KWKEGCCEVI EKDNKYCLVV NYNAGGMPTR FQLNQNIKTI 60
VVKPNGGTQS RFMLTLKDAS SLTIDKVPLK DAENLKHFLE SLDKATIVLL VKSNQGSGSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAATTGGT GCTTGCGTGA CAGTCGGCGC TCTGAGAGAA CTGGAAGGAG AGCAAGGAGA 60
ACCAGAGAAG GTGAGGGACG GGGGGCCGCC GGGAGAAGCA TACAATCACA GTGACAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR003903--UIM_dom
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001400	Ailuropoda melanoleuca	65.33	0.00e+00	1139.00
IUUC-Apl-004033	Anas platyrhynchos	68.54	0.00e+00	1238.00
IUUC-Aca-005370	Anolis carolinensis	63.92	0.00e+00	1122.00
IUUC-Ame-011884	Astyanax mexicanus	57.06	0.00e+00	928.00
IUUC-Bta-012725	Bos taurus	64.34	0.00e+00	1113.00
IUUC-Cja-019939	Callithrix jacchus	64.88	0.00e+00	1106.00
IUUC-Cfa-020835	Canis familiaris	65.16	0.00e+00	1154.00
IUUC-Cpo-022067	Cavia porcellus	63.80	0.00e+00	1006.00
IUUC-Cre-022867	Chlamydomonas reinhardtii	28.80	5.00e-22	99.80
IUUC-Csa-023085	Chlorocebus sabaeus	65.15	0.00e+00	1133.00
IUUC-Cho-024390	Choloepus hoffmanni	49.04	2.00e-91	330.00
IUUC-Cin-025496	Ciona intestinalis	33.80	2.00e-45	176.00
IUUC-Csv-025812	Ciona savignyi	32.50	3.00e-39	156.00
IUUC-Dre-028255	Danio rerio	56.43	0.00e+00	883.00
IUUC-Dno-028986	Dasypus novemcinctus	64.50	0.00e+00	1114.00
IUUC-Dor-031062	Dipodomys ordii	55.31	3.00e-167	582.00
IUUC-Ete-032359	Echinops telfairi	56.83	2.00e-149	523.00
IUUC-Eca-033964	Equus caballus	65.10	0.00e+00	1136.00
IUUC-Eeu-034492	Erinaceus europaeus	63.57	1.00e-157	550.00
IUUC-Fca-036359	Felis catus	65.46	0.00e+00	1143.00
IUUC-Fal-037640	Ficedula albicollis	68.41	0.00e+00	1205.00
IUUC-Gmo-039600	Gadus morhua	54.84	0.00e+00	873.00
IUUC-Gga-040126	Gallus gallus	68.27	0.00e+00	1167.00
IUUC-Gac-041557	Gasterosteus aculeatus	54.46	0.00e+00	840.00
IUUC-Ggo-045571	Gorilla gorilla	62.79	0.00e+00	985.00
IUUC-Hsa-046043	Homo sapiens	65.12	0.00e+00	1119.00
IUUC-Itr-048207	Ictidomys tridecemlineatus	64.91	0.00e+00	1115.00
IUUC-Lch-050357	Latimeria chalumnae	61.82	0.00e+00	927.00
IUUC-Loc-052849	Lepisosteus oculatus	59.68	0.00e+00	954.00
IUUC-Laf-054570	Loxodonta africana	64.03	0.00e+00	1086.00
IUUC-Mcc-054989	Macaca mulatta	63.98	0.00e+00	1030.00
IUUC-Meu-056273	Macropus eugenii	47.89	7.00e-111	395.00
IUUC-Mga-059814	Meleagris gallopavo	66.67	0.00e+00	1153.00
IUUC-Mmr-061726	Microcebus murinus	65.35	0.00e+00	1132.00
IUUC-Mdo-062974	Monodelphis domestica	67.11	0.00e+00	1187.00
IUUC-Mmu-064069	Mus musculus	63.13	0.00e+00	1075.00
IUUC-Mpu-066008	Mustela putorius furo	65.26	0.00e+00	1123.00
IUUC-Mlu-068224	Myotis lucifugus	35.98	7.00e-120	424.00
IUUC-Nle-069259	Nomascus leucogenys	65.05	0.00e+00	1113.00
IUUC-Opr-070882	Ochotona princeps	63.36	1.00e-102	368.00
IUUC-Ont-072441	Oreochromis niloticus	55.05	0.00e+00	866.00
IUUC-Oan-073151	Ornithorhynchus anatinus	73.95	1.00e-102	365.00
IUUC-Ocu-074879	Oryctolagus cuniculus	64.75	0.00e+00	1110.00
IUUC-Ola-087007	Oryzias latipes	52.77	0.00e+00	820.00
IUUC-Oga-088385	Otolemur garnettii	64.69	0.00e+00	1126.00
IUUC-Oar-090305	Ovis aries	65.25	0.00e+00	1137.00
IUUC-Ptr-091299	Pan troglodytes	65.12	0.00e+00	1115.00
IUUC-Pan-091996	Papio anubis	65.80	0.00e+00	1111.00
IUUC-Psi-093176	Pelodiscus sinensis	67.90	0.00e+00	1225.00
IUUC-Pma-094331	Petromyzon marinus	45.72	0.00e+00	691.00
IUUC-Pfo-096503	Poecilia formosa	55.42	0.00e+00	848.00
IUUC-Pab-098543	Pongo abelii	68.68	0.00e+00	638.00
IUUC-Pca-101099	Procavia capensis	63.56	0.00e+00	880.00
IUUC-Pva-103163	Pteropus vampyrus	62.30	0.00e+00	752.00
IUUC-Rno-105766	Rattus norvegicus	63.40	0.00e+00	1073.00
IUUC-Sha-106610	Sarcophilus harrisii	63.88	0.00e+00	1089.00
IUUC-Sar-113624	Sorex araneus	39.71	1.00e-15	78.60
IUUC-Ssc-116353	Sus scrofa	64.31	0.00e+00	1100.00
IUUC-Tgu-116971	Taeniopygia guttata	68.07	0.00e+00	1180.00
IUUC-Tru-117932	Takifugu rubripes	44.41	4.00e-169	588.00
IUUC-Tsy-119185	Tarsius syrichta	61.61	0.00e+00	756.00
IUUC-Tni-119842	Tetraodon nigroviridis	61.28	4.00e-104	372.00
IUUC-Tbe-127281	Tupaia belangeri	50.82	4.00e-107	382.00
IUUC-Ttr-128177	Tursiops truncatus	70.79	0.00e+00	934.00
IUUC-Vpa-130031	Vicugna pacos	65.76	0.00e+00	1152.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence