iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/PH/GLUE	GLUE	16973552; 17057714; 17057716

Classification

Family	E-value	Score	Start	End
UBD/PH/GLUE	9.80e-74	247.6	1	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/PH/GLUE

   S: 1    mdrfvytealLeinetlvirqrsvkiydgdekikfdaGellLtthRLiWirdqkneevtlaipLsavvfieeeaaaigksakivvhlhpars 92
           mdrfv+t++lLeinetlvi+qr+v+iydg+ekikfdaG+llL+thRLiW rdqkn+e+++ai+Ls++vfiee+aa+igksakivvhlhpa++
   Q: 1    MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIW-RDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPP 91
           9************************************************.****************************************** PP
   S: 93   dkePGpldsskasyiklsfkekgdiefyskLseeltaRaWeelevse 139
           +kePGp++ssk+syiklsfke+g+iefy++Lsee+t+R+We+++vs+
   Q: 92   NKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQ 138
           *********************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS36 and two copies of VPS25 (PubMed:14519844). Interacts with VPS25, SNF8, TSG101 and CHMP6 (PubMed:14505570, PubMed:14519844, PubMed:16973552, PubMed:18539118). Interacts (via GLUE domain) with ubiquitin (PubMed:17057716). Interacts with RILPL1 (via the C-terminal domain); which recruits ESCRT-II to the endosome membranes (PubMed:17010938). Interacts with ECM29 (PubMed:20682791).

Protein Sequence
(Fasta)

MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA 60
ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCTCGGAG GGCCGGGGCT GGGTGGCAGC GGCCATGGAC CGCTTCGTTT GGACCAGCGG 60
CCTCCTGGAG ATCAACGAGA CCCTGGTGAT CCAGCAGCGC GGGGTGCGAA TCTACGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0813--Transport

Interpro

IPR007286--EAP30
IPR021648--GLUE_dom
IPR011993--PH_dom-like
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS51495--GLUE

Pfam

PF04157--EAP30
PF11605--Vps36_ESCRT-II

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0000814--C:ESCRT II complex
GO:0070062--C:extracellular exosome
GO:0031902--C:late endosome membrane
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0008022--F:protein C-terminus binding
GO:0043130--F:ubiquitin binding
GO:0016197--P:endosomal transport
GO:0016236--P:macroautophagy
GO:0036258--P:multivesicular body assembly
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:51028

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000963	Aegilops tauschii	41.88	7.00e-35	140.00
IUUC-Aml-002313	Ailuropoda melanoleuca	98.19	0.00e+00	754.00
IUUC-Atr-003096	Amborella trichopoda	36.05	2.00e-15	75.90
IUUC-Apl-003218	Anas platyrhynchos	88.45	0.00e+00	681.00
IUUC-Aca-004580	Anolis carolinensis	90.41	0.00e+00	700.00
IUUC-Aly-006398	Arabidopsis lyrata	37.32	1.00e-57	217.00
IUUC-Ath-006907	Arabidopsis thaliana	37.90	3.00e-57	216.00
IUUC-Ago-007840	Ashbya gossypii	22.08	3.00e-04	40.40
IUUC-Acl-008117	Aspergillus clavatus	32.21	3.00e-36	146.00
IUUC-Afl-008595	Aspergillus flavus	32.56	3.00e-36	146.00
IUUC-Afu-008918	Aspergillus fumigatus	31.61	8.00e-36	145.00
IUUC-Ani-009206	Aspergillus nidulans	32.94	4.00e-36	146.00
IUUC-Ang-009784	Aspergillus niger	32.62	5.00e-33	136.00
IUUC-Aor-010126	Aspergillus oryzae	32.56	3.00e-36	146.00
IUUC-Ate-010303	Aspergillus terreus	33.13	3.00e-34	140.00
IUUC-Ame-011190	Astyanax mexicanus	85.08	0.00e+00	663.00
IUUC-Bgr-011979	Blumeria graminis	31.46	3.00e-33	136.00
IUUC-Bta-012661	Bos taurus	98.19	0.00e+00	752.00
IUUC-Bci-013982	Botrytis cinerea	32.97	4.00e-33	136.00
IUUC-Bdi-014753	Brachypodium distachyon	40.21	4.00e-51	195.00
IUUC-Bol-015465	Brassica oleracea	42.25	1.00e-49	190.00
IUUC-Bra-016794	Brassica rapa	42.69	1.00e-50	193.00
IUUC-Cel-018514	Caenorhabditis elegans	42.12	7.00e-82	297.00
IUUC-Cja-019285	Callithrix jacchus	98.31	0.00e+00	687.00
IUUC-Cfa-020746	Canis familiaris	98.96	0.00e+00	759.00
IUUC-Cpo-022005	Cavia porcellus	97.46	0.00e+00	687.00
IUUC-Cre-022686	Chlamydomonas reinhardtii	35.63	6.00e-33	135.00
IUUC-Csa-023520	Chlorocebus sabaeus	99.74	0.00e+00	767.00
IUUC-Cho-024957	Choloepus hoffmanni	93.78	0.00e+00	714.00
IUUC-Cin-025575	Ciona intestinalis	47.62	5.00e-08	48.90
IUUC-Csv-025942	Ciona savignyi	53.11	2.00e-108	385.00
IUUC-Cgl-026558	Colletotrichum gloeosporioides	32.14	1.00e-30	128.00
IUUC-Cne-026915	Cryptococcus neoformans	27.97	1.00e-23	104.00
IUUC-Cme-027099	Cyanidioschyzon merolae	24.68	1.00e-11	65.10
IUUC-Dre-027753	Danio rerio	84.82	0.00e+00	662.00
IUUC-Dno-029922	Dasypus novemcinctus	95.85	0.00e+00	739.00
IUUC-Dor-030643	Dipodomys ordii	90.67	0.00e+00	685.00
IUUC-Dse-031368	Dothistroma septosporum	32.08	2.00e-29	124.00
IUUC-Dme-031977	Drosophila melanogaster	45.11	2.00e-92	332.00
IUUC-Ete-033135	Echinops telfairi	75.07	8.00e-142	496.00
IUUC-Eca-033937	Equus caballus	97.74	0.00e+00	691.00
IUUC-Eeu-034483	Erinaceus europaeus	93.52	0.00e+00	743.00
IUUC-Fca-035496	Felis catus	98.02	0.00e+00	688.00
IUUC-Fal-036743	Ficedula albicollis	89.90	0.00e+00	701.00
IUUC-Fox-037685	Fusarium oxysporum	34.80	9.00e-27	115.00
IUUC-Fso-038421	Fusarium solani	31.19	2.00e-28	121.00
IUUC-Gmo-039456	Gadus morhua	79.11	4.00e-175	607.00
IUUC-Ggr-039763	Gaeumannomyces graminis	31.72	9.00e-36	145.00
IUUC-Gga-040556	Gallus gallus	89.64	0.00e+00	696.00
IUUC-Gac-041481	Gasterosteus aculeatus	80.73	4.00e-160	557.00
IUUC-Gma-044185	Glycine max	44.26	5.00e-53	202.00
IUUC-Ggo-044849	Gorilla gorilla	100.00	0.00e+00	768.00
IUUC-Hvu-047858	Hordeum vulgare	38.68	3.00e-13	68.90
IUUC-Itr-048068	Ictidomys tridecemlineatus	95.36	0.00e+00	730.00
IUUC-Kpa-049240	Komagataella pastoris	26.51	1.00e-05	45.10
IUUC-Lch-050293	Latimeria chalumnae	87.74	1.00e-125	442.00
IUUC-Lpe-051363	Leersia perrieri	45.08	2.00e-51	196.00
IUUC-Loc-052866	Lepisosteus oculatus	84.72	0.00e+00	642.00
IUUC-Lma-053139	Leptosphaeria maculans	29.19	8.00e-32	132.00
IUUC-Laf-053881	Loxodonta africana	91.97	0.00e+00	701.00
IUUC-Mcc-055158	Macaca mulatta	99.48	0.00e+00	766.00
IUUC-Meu-056126	Macropus eugenii	74.58	2.00e-136	478.00
IUUC-Mor-057092	Magnaporthe oryzae	31.25	1.00e-32	135.00
IUUC-Mpo-057629	Magnaporthe poae	31.88	8.00e-28	117.00
IUUC-Mtr-058039	Medicago truncatula	44.86	1.00e-53	203.00
IUUC-Mla-058913	Melampsora laricipopulina	30.87	1.00e-23	104.00
IUUC-Mga-059956	Meleagris gallopavo	89.64	0.00e+00	698.00
IUUC-Mvi-060570	Microbotryum violaceum	23.92	4.00e-17	83.60
IUUC-Mmr-061769	Microcebus murinus	98.59	0.00e+00	691.00
IUUC-Mdo-062751	Monodelphis domestica	91.62	0.00e+00	712.00
IUUC-Mmu-063115	Mus musculus	95.85	0.00e+00	744.00
IUUC-Mac-064979	Musa acuminata	35.58	8.00e-53	201.00
IUUC-Mpu-066904	Mustela putorius furo	98.31	8.00e-139	485.00
IUUC-Mlu-067474	Myotis lucifugus	97.41	0.00e+00	747.00
IUUC-Nfi-068588	Neosartorya fischeri	32.21	1.00e-32	134.00
IUUC-Ncr-068855	Neurospora crassa	29.71	2.00e-27	117.00
IUUC-Nle-069660	Nomascus leucogenys	99.22	0.00e+00	763.00
IUUC-Opr-070695	Ochotona princeps	96.37	0.00e+00	739.00
IUUC-Ont-071837	Oreochromis niloticus	83.51	2.00e-174	605.00
IUUC-Oan-072903	Ornithorhynchus anatinus	93.26	0.00e+00	663.00
IUUC-Ocu-074833	Oryctolagus cuniculus	97.15	0.00e+00	751.00
IUUC-Oba-075899	Oryza barthii	45.42	1.00e-51	196.00
IUUC-Obr-076125	Oryza brachyantha	35.73	3.00e-55	209.00
IUUC-Ogl-077538	Oryza glaberrima	50.00	3.00e-32	133.00
IUUC-Ogu-078272	Oryza glumaepatula	45.08	1.00e-51	197.00
IUUC-Oin-079158	Oryza indica	44.35	4.00e-51	195.00
IUUC-Olo-080496	Oryza longistaminata	44.17	9.00e-48	183.00
IUUC-Ome-081440	Oryza meridionalis	44.77	2.00e-49	189.00
IUUC-Oni-083069	Oryza nivara	44.35	4.00e-51	195.00
IUUC-Opu-083838	Oryza punctata	45.53	5.00e-50	191.00
IUUC-Oru-084377	Oryza rufipogon	45.08	1.00e-51	197.00
IUUC-Osa-085976	Oryza sativa	45.08	1.00e-51	197.00
IUUC-Ola-086431	Oryzias latipes	84.82	3.00e-177	614.00
IUUC-Olu-087789	Ostreococcus lucimarinus	39.30	2.00e-39	155.00
IUUC-Oga-089152	Otolemur garnettii	97.67	0.00e+00	749.00
IUUC-Oar-089198	Ovis aries	98.02	0.00e+00	687.00
IUUC-Ptr-091123	Pan troglodytes	100.00	0.00e+00	768.00
IUUC-Pan-092866	Papio anubis	96.12	0.00e+00	737.00
IUUC-Psi-093384	Pelodiscus sinensis	94.04	0.00e+00	725.00
IUUC-Pno-094773	Phaeosphaeria nodorum	30.79	2.00e-27	117.00
IUUC-Ppa-095753	Physcomitrella patens	36.20	6.00e-56	211.00
IUUC-Pfo-096028	Poecilia formosa	83.51	5.00e-176	610.00
IUUC-Pop-098915	Populus trichocarpa	44.86	2.00e-52	200.00
IUUC-Pca-100422	Procavia capensis	94.63	0.00e+00	660.00
IUUC-Ppe-101564	Prunus persica	44.90	8.00e-54	204.00
IUUC-Pva-103019	Pteropus vampyrus	93.01	0.00e+00	702.00
IUUC-Pgr-103670	Puccinia graminis	28.05	3.00e-20	93.60
IUUC-Ptt-103958	Puccinia triticina	26.77	3.00e-19	89.70
IUUC-Pte-104343	Pyrenophora teres	31.52	1.00e-37	151.00
IUUC-Pyt-104554	Pyrenophora triticirepentis	31.34	2.00e-39	157.00
IUUC-Rno-105775	Rattus norvegicus	96.11	0.00e+00	744.00
IUUC-Sce-106148	Saccharomyces cerevisiae	22.29	1.10e-02	35.00
IUUC-Sha-106468	Sarcophilus harrisii	93.50	0.00e+00	657.00
IUUC-Sja-107850	Schizosaccharomyces japonicus	23.51	2.00e-16	80.90
IUUC-Spo-108225	Schizosaccharomyces pombe	23.37	2.00e-17	83.60
IUUC-Ssl-108412	Sclerotinia sclerotiorum	32.35	2.00e-30	127.00
IUUC-Smo-109001	Selaginella moellendorffii	35.33	9.00e-54	204.00
IUUC-Sit-110126	Setaria italica	34.32	6.00e-49	188.00
IUUC-Sly-110884	Solanum lycopersicum	36.34	4.00e-52	198.00
IUUC-Stu-112573	Solanum tuberosum	35.88	2.00e-52	199.00
IUUC-Sar-113114	Sorex araneus	94.03	1.00e-70	259.00
IUUC-Sbi-114331	Sorghum bicolor	29.86	6.00e-38	151.00
IUUC-Sre-115135	Sporisorium reilianum	22.91	1.00e-09	58.50
IUUC-Ssc-116158	Sus scrofa	98.70	0.00e+00	759.00
IUUC-Tgu-116962	Taeniopygia guttata	89.64	0.00e+00	669.00
IUUC-Tru-117567	Takifugu rubripes	83.25	9.00e-176	609.00
IUUC-Tsy-119357	Tarsius syrichta	81.87	2.00e-167	581.00
IUUC-Tni-120047	Tetraodon nigroviridis	83.09	9.00e-156	542.00
IUUC-Tca-121097	Theobroma cacao	44.86	1.00e-53	204.00
IUUC-Tre-122075	Trichoderma reesei	30.14	3.00e-33	136.00
IUUC-Tvi-122623	Trichoderma virens	32.54	2.00e-39	157.00
IUUC-Tae-123728	Triticum aestivum	43.44	6.00e-51	195.00
IUUC-Tur-125988	Triticum urartu	42.35	1.00e-40	160.00
IUUC-Tme-126936	Tuber melanosporum	31.11	9.00e-34	138.00
IUUC-Tbe-127481	Tupaia belangeri	68.08	1.00e-128	452.00
IUUC-Ttr-128160	Tursiops truncatus	97.41	0.00e+00	739.00
IUUC-Uma-129428	Ustilago maydis	24.83	8.00e-17	82.40
IUUC-Vda-129877	Verticillium dahliae	32.08	5.00e-29	122.00
IUUC-Vpa-130358	Vicugna pacos	98.02	0.00e+00	682.00
IUUC-Vvi-131406	Vitis vinifera	36.70	2.00e-56	213.00
IUUC-Xtr-132548	Xenopus tropicalis	85.01	0.00e+00	651.00
IUUC-Xma-133352	Xiphophorus maculatus	83.77	3.00e-176	610.00
IUUC-Yli-134466	Yarrowia lipolytica	30.77	3.00e-20	93.20
IUUC-Zma-135081	Zea mays	40.14	7.00e-51	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence