iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000137764.19	ENST00000178640.9	ENSP00000178640.5
ENSG00000137764.19	ENST00000395476.6	ENSP00000378859.2
ENSG00000137764.19	ENST00000354498.9	ENSP00000346493.5
ENSG00000137764.19	ENST00000559262.5	ENSP00000480580.1
ENSG00000137764.19	ENST00000340972.8	ENSP00000342101.4
ENSG00000137764.19	ENST00000557869.2	ENSP00000483771.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	16949360; 17726178

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	1.50e-17	65.2	19	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla...skksllrlliq 82
           +r+k+ ++g+++ +++++ ++++f+d+l+++ +   l++ +++a++YeDedGD++t++sDe++++++s+++   ++++++ +li+
   Q: 19   IRIKIPNSGAVD-WTVHSGPQLLFRDVLDVIGQ--VLPEaTTTAFEYEDEDGDRITVRSDEEMKAMLSYYYstvMEQQVNGQLIE 100
           89*********8.9*******************..****9******************************9**888888888886 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Protein Sequence
(Fasta)

MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTCCTCC TCTCGCCGCT ACCGCCGTCG CCGCCGCCGC AGCCGCCGCC AGTCCGCGCG 60
GCCTCGGGTG GCCGGAGCTC AGCCTGCGCG CGCCGCGCCC TGTGTCTCCG GGTGGGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0000187--P:activation of MAPK activity
GO:0071363--P:cellular response to growth factor stimulus
GO:0071499--P:cellular response to laminar fluid shear stress
GO:0070375--P:ERK5 cascade
GO:0007507--P:heart development
GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342--P:negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0034115--P:negative regulation of heterotypic cell-cell adhesion
GO:0045415--P:negative regulation of interleukin-8 biosynthetic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0060761--P:negative regulation of response to cytokine stimulus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0051247--P:positive regulation of protein metabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007165--P:signal transduction

KEGG

hsa:5607

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001360	Ailuropoda melanoleuca	98.44	0.00e+00	919.00
IUUC-Ame-011344	Astyanax mexicanus	61.74	2.00e-149	522.00
IUUC-Bta-013163	Bos taurus	98.66	0.00e+00	880.00
IUUC-Cja-019978	Callithrix jacchus	98.66	0.00e+00	923.00
IUUC-Cfa-020966	Canis familiaris	98.66	0.00e+00	921.00
IUUC-Cpo-021409	Cavia porcellus	97.54	0.00e+00	910.00
IUUC-Cre-022653	Chlamydomonas reinhardtii	37.02	1.00e-50	194.00
IUUC-Csa-024057	Chlorocebus sabaeus	100.00	0.00e+00	932.00
IUUC-Cin-025732	Ciona intestinalis	47.40	2.00e-102	366.00
IUUC-Csv-026157	Ciona savignyi	47.30	2.00e-99	356.00
IUUC-Dre-028281	Danio rerio	79.77	0.00e+00	658.00
IUUC-Dno-029823	Dasypus novemcinctus	97.26	0.00e+00	662.00
IUUC-Dor-031066	Dipodomys ordii	100.00	4.00e-108	385.00
IUUC-Eca-033333	Equus caballus	97.08	0.00e+00	889.00
IUUC-Gga-040887	Gallus gallus	93.10	0.00e+00	811.00
IUUC-Ggo-044887	Gorilla gorilla	100.00	0.00e+00	932.00
IUUC-Itr-048806	Ictidomys tridecemlineatus	98.21	0.00e+00	918.00
IUUC-Lch-049414	Latimeria chalumnae	90.36	0.00e+00	834.00
IUUC-Loc-052592	Lepisosteus oculatus	82.67	0.00e+00	721.00
IUUC-Laf-054533	Loxodonta africana	97.99	0.00e+00	909.00
IUUC-Mcc-055537	Macaca mulatta	99.78	0.00e+00	929.00
IUUC-Meu-056484	Macropus eugenii	84.54	0.00e+00	674.00
IUUC-Mga-059477	Meleagris gallopavo	92.22	0.00e+00	822.00
IUUC-Mmr-061306	Microcebus murinus	98.88	0.00e+00	920.00
IUUC-Mdo-061813	Monodelphis domestica	97.40	0.00e+00	785.00
IUUC-Mmu-064419	Mus musculus	97.77	0.00e+00	912.00
IUUC-Nle-069351	Nomascus leucogenys	99.52	0.00e+00	852.00
IUUC-Opr-070735	Ochotona princeps	97.12	0.00e+00	904.00
IUUC-Ont-072335	Oreochromis niloticus	78.15	0.00e+00	710.00
IUUC-Ocu-074413	Oryctolagus cuniculus	98.21	0.00e+00	916.00
IUUC-Ola-086909	Oryzias latipes	79.59	0.00e+00	710.00
IUUC-Oga-088949	Otolemur garnettii	97.21	0.00e+00	720.00
IUUC-Oar-089529	Ovis aries	98.88	0.00e+00	922.00
IUUC-Ptr-090951	Pan troglodytes	100.00	0.00e+00	932.00
IUUC-Pan-091891	Papio anubis	99.78	0.00e+00	930.00
IUUC-Psi-093134	Pelodiscus sinensis	91.95	0.00e+00	730.00
IUUC-Pfo-097277	Poecilia formosa	78.62	0.00e+00	702.00
IUUC-Pab-098107	Pongo abelii	100.00	0.00e+00	932.00
IUUC-Pca-101027	Procavia capensis	80.09	0.00e+00	704.00
IUUC-Pva-102374	Pteropus vampyrus	91.96	0.00e+00	786.00
IUUC-Rno-105325	Rattus norvegicus	98.21	0.00e+00	917.00
IUUC-Sha-107478	Sarcophilus harrisii	96.64	0.00e+00	901.00
IUUC-Ssc-115454	Sus scrofa	98.36	3.00e-69	253.00
IUUC-Tru-117913	Takifugu rubripes	78.97	0.00e+00	691.00
IUUC-Tsy-119406	Tarsius syrichta	97.34	0.00e+00	837.00
IUUC-Tni-120439	Tetraodon nigroviridis	77.98	0.00e+00	689.00
IUUC-Tbe-127650	Tupaia belangeri	72.95	1.00e-162	565.00
IUUC-Ttr-128626	Tursiops truncatus	99.11	0.00e+00	923.00
IUUC-Xtr-131841	Xenopus tropicalis	83.89	0.00e+00	736.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence