iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055537

Ensembl Protein ID

ENSMMUP00000046932.1

UniProt Accession

H9EPL8; H9EPL8_MACMU

Genbank Protein ID

AFE64327.1; AFH27372.1; AFI34967.1

Protein Name

Dual specificity mitogen-activated protein kinase kinase 5 isoform A

Genbank Nucleotide ID

JSUE03038599; JU470568; JV044896

Gene Name

MAP2K5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000014482.3	ENSMMUT00000069786.1	ENSMMUP00000046932.1
ENSMMUG00000014482.3	ENSMMUT00000020318.3	ENSMMUP00000019017.3
ENSMMUG00000014482.3	ENSMMUT00000074094.1	ENSMMUP00000046121.1
ENSMMUG00000014482.3	ENSMMUT00000020317.3	ENSMMUP00000019016.3
ENSMMUG00000014482.3	ENSMMUT00000070927.1	ENSMMUP00000041706.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	1.00e-17	65.2	19	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla...skksllrlliq 82
           +r+k+ ++g+++ +++++ ++++f+d+l+++ +   l++ +++a++YeDedGD++t++sDe++++++s+++   ++++++ +li+
   Q: 19   IRIKIPNSGAVD-WTVHSGPQLLFRDVLDVIGQ--VLPEaTTTAFEYEDEDGDRITVRSDEEMKAMLSYYYstvMEQQVNGQLIE 100
           89*********8.9*******************..****9******************************9**888888888886 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAACATGGCG CCGCGGGAGG CGGGTCCCGC TCGTTGGCTC CCGGGGTTCC GGCGCCGCGC 60
GTTTTGGTTC CGGAGTAACA GTGTCGCCGC CGCCTTCCTC CTCCTCCTCT TGCCGCTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005819--C:spindle
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007507--P:heart development
GO:0000165--P:MAPK cascade

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001360	Ailuropoda melanoleuca	98.21	0.00e+00	916.00
IUUC-Ame-011344	Astyanax mexicanus	61.74	2.00e-149	522.00
IUUC-Bta-013163	Bos taurus	98.44	0.00e+00	878.00
IUUC-Cja-019978	Callithrix jacchus	98.44	0.00e+00	921.00
IUUC-Cfa-020966	Canis familiaris	98.44	0.00e+00	918.00
IUUC-Cpo-021409	Cavia porcellus	97.32	0.00e+00	907.00
IUUC-Cre-022653	Chlamydomonas reinhardtii	37.02	1.00e-50	194.00
IUUC-Csa-024057	Chlorocebus sabaeus	99.78	0.00e+00	929.00
IUUC-Cin-025732	Ciona intestinalis	47.40	1.00e-102	366.00
IUUC-Csv-026157	Ciona savignyi	47.52	1.00e-99	357.00
IUUC-Dre-028281	Danio rerio	79.53	0.00e+00	656.00
IUUC-Dno-029823	Dasypus novemcinctus	96.95	0.00e+00	660.00
IUUC-Dor-031066	Dipodomys ordii	100.00	3.00e-108	385.00
IUUC-Eca-033333	Equus caballus	96.85	0.00e+00	885.00
IUUC-Gga-040887	Gallus gallus	92.87	0.00e+00	808.00
IUUC-Ggo-044887	Gorilla gorilla	99.78	0.00e+00	929.00
IUUC-Hsa-047038	Homo sapiens	99.78	0.00e+00	929.00
IUUC-Itr-048806	Ictidomys tridecemlineatus	97.99	0.00e+00	915.00
IUUC-Lch-049414	Latimeria chalumnae	90.13	0.00e+00	831.00
IUUC-Loc-052592	Lepisosteus oculatus	82.44	0.00e+00	718.00
IUUC-Laf-054533	Loxodonta africana	97.76	0.00e+00	906.00
IUUC-Meu-056484	Macropus eugenii	84.30	0.00e+00	671.00
IUUC-Mga-059477	Meleagris gallopavo	92.00	0.00e+00	819.00
IUUC-Mmr-061306	Microcebus murinus	98.66	0.00e+00	917.00
IUUC-Mdo-061813	Monodelphis domestica	97.14	0.00e+00	781.00
IUUC-Mmu-064419	Mus musculus	97.54	0.00e+00	910.00
IUUC-Nle-069351	Nomascus leucogenys	99.28	0.00e+00	849.00
IUUC-Opr-070735	Ochotona princeps	96.90	0.00e+00	902.00
IUUC-Ont-072335	Oreochromis niloticus	77.93	0.00e+00	708.00
IUUC-Ocu-074413	Oryctolagus cuniculus	97.99	0.00e+00	913.00
IUUC-Ola-086909	Oryzias latipes	79.59	0.00e+00	711.00
IUUC-Oga-088949	Otolemur garnettii	96.93	0.00e+00	718.00
IUUC-Oar-089529	Ovis aries	98.66	0.00e+00	919.00
IUUC-Ptr-090951	Pan troglodytes	99.78	0.00e+00	929.00
IUUC-Pan-091891	Papio anubis	99.55	0.00e+00	927.00
IUUC-Psi-093134	Pelodiscus sinensis	91.71	0.00e+00	728.00
IUUC-Pfo-097277	Poecilia formosa	78.39	0.00e+00	699.00
IUUC-Pab-098107	Pongo abelii	99.78	0.00e+00	929.00
IUUC-Pca-101027	Procavia capensis	79.87	0.00e+00	701.00
IUUC-Pva-102374	Pteropus vampyrus	91.74	0.00e+00	783.00
IUUC-Rno-105325	Rattus norvegicus	97.99	0.00e+00	915.00
IUUC-Sha-107478	Sarcophilus harrisii	96.42	0.00e+00	899.00
IUUC-Ssc-115454	Sus scrofa	98.36	2.00e-69	253.00
IUUC-Tru-117913	Takifugu rubripes	78.74	0.00e+00	688.00
IUUC-Tsy-119406	Tarsius syrichta	97.10	0.00e+00	833.00
IUUC-Tni-120439	Tetraodon nigroviridis	77.75	0.00e+00	686.00
IUUC-Tbe-127650	Tupaia belangeri	72.71	7.00e-162	563.00
IUUC-Ttr-128626	Tursiops truncatus	98.88	0.00e+00	920.00
IUUC-Xtr-131841	Xenopus tropicalis	84.12	0.00e+00	738.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence