iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138100.13	ENST00000380075.6	ENSP00000369415.2
ENSG00000138100.13	ENST00000296098.4	ENSP00000296098.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17360532; 17786241

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.10e-09	37.5	26	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...........pglknssskefrCPlCr 46
           C+iCle+f++++++lpC+H  +++C + +                ss ++frCP Cr
   Q: 26   CPICLEMFSKPVVILPCQHNLCRKCANDVfqasnplwqsrGSTTVSSGGRFRCPSCR 82
           *************************87777777888899977777899********8 PP

Organism

Homo sapiens

Functional Description
(View)

May bind and stabilize microtubules during myotubes formation.

Protein Sequence
(Fasta)

MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP 60
LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGTAAAAT TAATCTGCTC TCTGGGGAGT AAGGGACAAA CAGTGCTACC CACAGAGTGA 60
ACAAGAGAGA GTCATTTGGG AAACAAAAGG AGAATTTTAC AGAGAGAGAG GGATAGCTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017903--COS_domain
IPR033492--TRIM54
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0030018--C:Z disc
GO:0004871--F:signal transducer activity
GO:0008270--F:zinc ion binding
GO:0007017--P:microtubule-based process
GO:0007275--P:multicellular organism development
GO:0055001--P:muscle cell development
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0007165--P:signal transduction

KEGG

hsa:57159

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002282	Ailuropoda melanoleuca	97.83	6.00e-134	469.00
IUUC-Bta-013385	Bos taurus	97.30	6.00e-177	613.00
IUUC-Cja-019697	Callithrix jacchus	78.89	2.00e-138	485.00
IUUC-Cfa-020995	Canis familiaris	98.48	2.00e-169	588.00
IUUC-Cpo-021913	Cavia porcellus	96.67	0.00e+00	667.00
IUUC-Csa-023342	Chlorocebus sabaeus	98.33	0.00e+00	648.00
IUUC-Cin-025224	Ciona intestinalis	52.43	4.00e-94	338.00
IUUC-Csv-026374	Ciona savignyi	52.33	8.00e-82	296.00
IUUC-Dre-027562	Danio rerio	69.73	1.00e-144	506.00
IUUC-Dno-029582	Dasypus novemcinctus	98.18	4.00e-171	594.00
IUUC-Dor-031139	Dipodomys ordii	94.15	0.00e+00	639.00
IUUC-Ete-032346	Echinops telfairi	99.51	6.00e-109	387.00
IUUC-Eca-033645	Equus caballus	97.90	2.00e-178	618.00
IUUC-Eeu-035333	Erinaceus europaeus	69.12	2.00e-115	409.00
IUUC-Fca-035865	Felis catus	97.88	0.00e+00	629.00
IUUC-Fal-036978	Ficedula albicollis	81.46	3.00e-166	577.00
IUUC-Gga-040452	Gallus gallus	78.41	1.00e-162	566.00
IUUC-Ggo-044467	Gorilla gorilla	89.25	3.00e-176	610.00
IUUC-Itr-047912	Ictidomys tridecemlineatus	95.26	0.00e+00	631.00
IUUC-Lch-050029	Latimeria chalumnae	78.35	7.00e-153	533.00
IUUC-Loc-051801	Lepisosteus oculatus	80.97	7.00e-136	476.00
IUUC-Laf-054215	Loxodonta africana	96.39	0.00e+00	665.00
IUUC-Mcc-055027	Macaca mulatta	88.31	0.00e+00	631.00
IUUC-Meu-056412	Macropus eugenii	93.54	1.00e-165	575.00
IUUC-Mmr-060920	Microcebus murinus	96.94	0.00e+00	654.00
IUUC-Mdo-062832	Monodelphis domestica	96.66	8.00e-165	572.00
IUUC-Mmu-063707	Mus musculus	93.89	1.00e-176	612.00
IUUC-Mlu-067653	Myotis lucifugus	81.54	3.00e-138	484.00
IUUC-Nle-069020	Nomascus leucogenys	99.44	0.00e+00	659.00
IUUC-Opr-070577	Ochotona princeps	79.25	2.00e-143	501.00
IUUC-Ont-072491	Oreochromis niloticus	62.25	3.00e-120	424.00
IUUC-Oan-073101	Ornithorhynchus anatinus	95.45	3.00e-172	597.00
IUUC-Ocu-074454	Oryctolagus cuniculus	96.11	2.00e-179	621.00
IUUC-Oga-088361	Otolemur garnettii	99.40	1.00e-176	612.00
IUUC-Oar-089950	Ovis aries	81.38	6.00e-140	490.00
IUUC-Ptr-090785	Pan troglodytes	89.50	4.00e-177	613.00
IUUC-Pan-092344	Papio anubis	98.61	0.00e+00	651.00
IUUC-Pab-098322	Pongo abelii	96.09	0.00e+00	625.00
IUUC-Pca-100385	Procavia capensis	76.43	6.00e-121	426.00
IUUC-Rno-105134	Rattus norvegicus	95.28	0.00e+00	673.00
IUUC-Sha-106768	Sarcophilus harrisii	96.35	1.00e-177	615.00
IUUC-Tgu-117494	Taeniopygia guttata	80.12	2.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence