iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-42	143.7	341	376
UBD/Beta-Prp	4.90e-46	158.9	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNIVKLWDTRSCK 376
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkll 172
           t+++++tl+gh + v s+ +s   + + s+s+d tirvwd+e+g+  + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g+l+
   Q: 246  TRTPIVTLSGHMEAVSSVLWSD-AEEICSASWDHTIRVWDVESGSLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDGSLV 334
           67899****************9.99**********************9.***987.99**************************54456666 PP
   S: 173  rtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
               t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 335  SLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           644366.************9889*****************54566****************9.999********998765 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LKDKNEFHKH VEFDFLIKGQ 60
FLRMPLDKHM EMENISSEEV VEIEYVEKYT APQPEQCMFH DDWISSIKGA EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGATTTAC CCAGCCGTTG GGCGGCAGCT GTTCAATGGT CGCGTAGGCT GGGGATGGGC 60
GGGGTGACCT GAAGCCCCGC CCCAGCATAC CTGCGCAGCC GCAGTCGACA GGCTCTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0006364--P:rRNA processing

KEGG

hsa:55759

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.02	2.00e-56	213.00
IUUC-Aml-001997	Ailuropoda melanoleuca	96.83	0.00e+00	746.00
IUUC-Atr-002544	Amborella trichopoda	33.33	3.00e-55	209.00
IUUC-Apl-003981	Anas platyrhynchos	87.23	0.00e+00	645.00
IUUC-Aca-004370	Anolis carolinensis	84.94	0.00e+00	698.00
IUUC-Aly-006455	Arabidopsis lyrata	34.73	4.00e-58	218.00
IUUC-Ath-006669	Arabidopsis thaliana	34.15	4.00e-54	205.00
IUUC-Ago-007864	Ashbya gossypii	29.93	2.00e-36	146.00
IUUC-Acl-008177	Aspergillus clavatus	29.95	4.00e-37	149.00
IUUC-Afl-008617	Aspergillus flavus	29.74	5.00e-36	145.00
IUUC-Afu-008752	Aspergillus fumigatus	28.54	2.00e-33	137.00
IUUC-Ani-009136	Aspergillus nidulans	30.26	3.00e-36	146.00
IUUC-Ang-009701	Aspergillus niger	28.46	5.00e-34	139.00
IUUC-Aor-009884	Aspergillus oryzae	29.74	5.00e-36	145.00
IUUC-Ate-010472	Aspergillus terreus	29.88	5.00e-21	95.10
IUUC-Ame-011432	Astyanax mexicanus	76.12	0.00e+00	649.00
IUUC-Bgr-012218	Blumeria graminis	28.61	1.00e-32	134.00
IUUC-Bta-012829	Bos taurus	95.98	0.00e+00	771.00
IUUC-Bci-013953	Botrytis cinerea	30.36	4.00e-35	142.00
IUUC-Bdi-014351	Brachypodium distachyon	35.55	3.00e-55	209.00
IUUC-Bol-016514	Brassica oleracea	33.81	3.00e-53	202.00
IUUC-Bra-017876	Brassica rapa	33.74	8.00e-56	211.00
IUUC-Cel-018569	Caenorhabditis elegans	31.62	2.00e-46	179.00
IUUC-Cja-019468	Callithrix jacchus	98.11	0.00e+00	766.00
IUUC-Cfa-020471	Canis familiaris	95.04	0.00e+00	742.00
IUUC-Cpo-022260	Cavia porcellus	95.98	0.00e+00	757.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.96	5.00e-39	155.00
IUUC-Csa-023989	Chlorocebus sabaeus	99.05	0.00e+00	775.00
IUUC-Cho-024426	Choloepus hoffmanni	92.38	2.00e-158	552.00
IUUC-Cin-025789	Ciona intestinalis	43.65	9.00e-97	347.00
IUUC-Cne-027063	Cryptococcus neoformans	24.34	1.00e-21	97.80
IUUC-Dre-027907	Danio rerio	77.07	0.00e+00	665.00
IUUC-Dno-029225	Dasypus novemcinctus	94.56	0.00e+00	762.00
IUUC-Dor-031082	Dipodomys ordii	78.25	1.00e-167	582.00
IUUC-Dse-031308	Dothistroma septosporum	28.05	9.00e-36	144.00
IUUC-Dme-032189	Drosophila melanogaster	41.75	6.00e-92	331.00
IUUC-Ete-032247	Echinops telfairi	88.18	0.00e+00	704.00
IUUC-Eca-034285	Equus caballus	95.98	0.00e+00	770.00
IUUC-Eeu-035322	Erinaceus europaeus	85.18	0.00e+00	642.00
IUUC-Fca-036114	Felis catus	95.51	0.00e+00	768.00
IUUC-Fal-036891	Ficedula albicollis	86.44	2.00e-173	601.00
IUUC-Fox-037965	Fusarium oxysporum	25.59	3.00e-34	139.00
IUUC-Fso-038244	Fusarium solani	26.64	1.00e-33	137.00
IUUC-Gmo-039040	Gadus morhua	75.65	0.00e+00	666.00
IUUC-Gga-040610	Gallus gallus	83.92	0.00e+00	707.00
IUUC-Gac-042117	Gasterosteus aculeatus	74.70	0.00e+00	644.00
IUUC-Gma-043146	Glycine max	37.17	3.00e-65	242.00
IUUC-Ggo-045179	Gorilla gorilla	99.29	0.00e+00	772.00
IUUC-Hvu-047331	Hordeum vulgare	33.59	6.00e-52	197.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	95.98	0.00e+00	769.00
IUUC-Kpa-049304	Komagataella pastoris	28.67	2.00e-40	160.00
IUUC-Lch-050655	Latimeria chalumnae	77.61	1.00e-142	499.00
IUUC-Lpe-051675	Leersia perrieri	34.84	1.00e-57	217.00
IUUC-Loc-052868	Lepisosteus oculatus	80.14	0.00e+00	662.00
IUUC-Lma-053258	Leptosphaeria maculans	27.03	7.00e-32	133.00
IUUC-Laf-053993	Loxodonta africana	94.56	0.00e+00	767.00
IUUC-Mcc-055128	Macaca mulatta	79.91	7.00e-174	603.00
IUUC-Meu-056501	Macropus eugenii	78.55	2.00e-160	558.00
IUUC-Mor-057114	Magnaporthe oryzae	26.48	3.00e-26	113.00
IUUC-Mtr-058367	Medicago truncatula	36.45	4.00e-59	222.00
IUUC-Mla-059107	Melampsora laricipopulina	27.43	1.00e-28	121.00
IUUC-Mga-059745	Meleagris gallopavo	81.88	0.00e+00	681.00
IUUC-Mvi-060362	Microbotryum violaceum	29.85	3.00e-35	143.00
IUUC-Mdo-062257	Monodelphis domestica	85.68	0.00e+00	715.00
IUUC-Mmu-063546	Mus musculus	93.85	0.00e+00	759.00
IUUC-Mac-065540	Musa acuminata	34.44	2.00e-54	206.00
IUUC-Mpu-066284	Mustela putorius furo	96.93	0.00e+00	777.00
IUUC-Mlu-067241	Myotis lucifugus	95.98	0.00e+00	772.00
IUUC-Nfi-068260	Neosartorya fischeri	28.29	2.00e-35	143.00
IUUC-Ncr-068719	Neurospora crassa	26.58	3.00e-27	116.00
IUUC-Nle-068981	Nomascus leucogenys	99.29	0.00e+00	758.00
IUUC-Opr-071218	Ochotona princeps	87.44	0.00e+00	668.00
IUUC-Ont-071646	Oreochromis niloticus	77.35	0.00e+00	666.00
IUUC-Oan-073453	Ornithorhynchus anatinus	88.89	0.00e+00	750.00
IUUC-Ocu-074008	Oryctolagus cuniculus	96.69	0.00e+00	776.00
IUUC-Oba-075712	Oryza barthii	30.53	6.00e-41	161.00
IUUC-Obr-076721	Oryza brachyantha	34.29	2.00e-57	216.00
IUUC-Ogl-077229	Oryza glaberrima	34.37	1.00e-56	214.00
IUUC-Ogu-078977	Oryza glumaepatula	30.53	3.00e-41	162.00
IUUC-Oin-079683	Oryza indica	34.37	8.00e-57	214.00
IUUC-Olo-080291	Oryza longistaminata	30.30	5.00e-28	118.00
IUUC-Ome-081834	Oryza meridionalis	34.61	9.00e-58	218.00
IUUC-Oni-082507	Oryza nivara	33.25	7.00e-53	201.00
IUUC-Opu-083396	Oryza punctata	34.61	6.00e-58	218.00
IUUC-Oru-085220	Oryza rufipogon	33.81	2.00e-52	199.00
IUUC-Osa-085767	Oryza sativa	34.37	8.00e-57	214.00
IUUC-Ola-087420	Oryzias latipes	77.54	0.00e+00	665.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.88	4.00e-35	142.00
IUUC-Oga-088264	Otolemur garnettii	96.22	0.00e+00	756.00
IUUC-Oar-089335	Ovis aries	95.51	0.00e+00	767.00
IUUC-Ptr-091320	Pan troglodytes	100.00	0.00e+00	778.00
IUUC-Pan-092833	Papio anubis	98.58	0.00e+00	770.00
IUUC-Psi-093504	Pelodiscus sinensis	87.23	0.00e+00	727.00
IUUC-Pma-094189	Petromyzon marinus	68.63	2.00e-169	588.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.91	1.00e-33	137.00
IUUC-Ppa-095429	Physcomitrella patens	35.61	8.00e-65	241.00
IUUC-Pfo-096337	Poecilia formosa	75.18	0.00e+00	666.00
IUUC-Pab-097571	Pongo abelii	99.53	0.00e+00	776.00
IUUC-Pop-099977	Populus trichocarpa	35.82	6.00e-63	234.00
IUUC-Pca-100394	Procavia capensis	88.51	0.00e+00	664.00
IUUC-Ppe-101848	Prunus persica	35.58	2.00e-59	223.00
IUUC-Pva-102921	Pteropus vampyrus	94.74	6.00e-114	404.00
IUUC-Pgr-103637	Puccinia graminis	28.60	7.00e-34	138.00
IUUC-Ptt-103781	Puccinia triticina	28.60	9.00e-34	138.00
IUUC-Pte-104135	Pyrenophora teres	26.07	1.00e-32	135.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.93	1.00e-31	130.00
IUUC-Rno-105114	Rattus norvegicus	93.38	0.00e+00	757.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.07	6.00e-38	152.00
IUUC-Sha-107122	Sarcophilus harrisii	86.13	0.00e+00	685.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.24	1.00e-48	187.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.82	2.00e-39	156.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.26	5.00e-36	145.00
IUUC-Smo-108720	Selaginella moellendorffii	33.10	6.00e-57	214.00
IUUC-Sit-110311	Setaria italica	35.55	1.00e-55	210.00
IUUC-Sly-111023	Solanum lycopersicum	32.52	5.00e-53	201.00
IUUC-Stu-112778	Solanum tuberosum	35.56	1.00e-59	223.00
IUUC-Sar-113596	Sorex araneus	78.49	7.00e-174	603.00
IUUC-Sbi-114193	Sorghum bicolor	34.96	7.00e-57	214.00
IUUC-Sre-115002	Sporisorium reilianum	25.00	8.00e-11	62.00
IUUC-Ssc-116066	Sus scrofa	96.22	0.00e+00	769.00
IUUC-Tgu-117048	Taeniopygia guttata	85.11	0.00e+00	636.00
IUUC-Tsy-119573	Tarsius syrichta	62.92	1.00e-131	462.00
IUUC-Tni-119820	Tetraodon nigroviridis	76.01	0.00e+00	665.00
IUUC-Tca-121605	Theobroma cacao	36.30	3.00e-60	225.00
IUUC-Tre-121947	Trichoderma reesei	26.28	8.00e-34	138.00
IUUC-Tvi-122481	Trichoderma virens	26.50	3.00e-35	142.00
IUUC-Tae-125861	Triticum aestivum	33.25	2.00e-56	213.00
IUUC-Tur-126586	Triticum urartu	33.85	3.00e-54	205.00
IUUC-Tme-126900	Tuber melanosporum	32.15	1.00e-48	187.00
IUUC-Tbe-127736	Tupaia belangeri	73.12	4.00e-152	531.00
IUUC-Ttr-129041	Tursiops truncatus	83.69	0.00e+00	656.00
IUUC-Vpa-130260	Vicugna pacos	96.69	0.00e+00	775.00
IUUC-Vvi-131009	Vitis vinifera	35.48	7.00e-60	224.00
IUUC-Xtr-132083	Xenopus tropicalis	81.56	0.00e+00	671.00
IUUC-Xma-133094	Xiphophorus maculatus	74.47	0.00e+00	660.00
IUUC-Yli-134531	Yarrowia lipolytica	23.25	2.00e-18	87.40
IUUC-Zma-135509	Zea mays	33.57	2.00e-57	216.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence