iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116974

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01012199

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000002965.1	ENSTGUT00000003172.1	ENSTGUP00000003142.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-92	309.8	725	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f++ ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 725  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTFYPESNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 806
           899*********************************************9999777554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkee.Yvkl 176
           +++ ++yk+ll++k  ledl+e+ p+  +sl++++++  +d+ee+ ++l+f++  e++g t++++L+++G++i V ++N++e +v++
   Q: 807  HFPLALYKKLLNVKPCLEDLKELSPTEGRSLQQLLDYTGEDVEET-FCLNFTICRESYGVTEQKNLIEDGDKILVQKDNRQEkFVEA 892
           *************************************99999997.******99*************************9644**** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v+y+++ +i+e ++af+ Gf +v+  ++l+lF++ el+ +i G++++++e+l++ + ykg+yt+++p++++Fwe+++ef  e++k+
   Q: 893  YVNYIFNFSIQEWYTAFSTGFLKVCGGKVLELFQPTELRAMIVGNSNYNWEELEESAIYKGDYTATHPTVRMFWETFHEFPLEKKKK 979
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL F+Tgs+r+P+ G+ +l+   ++i+   + ++ lP ++TC+n+L+LP+Ysskeil  +L  Ai++ +gF+l
   Q: 980  FLLFLTGSDRIPIYGMSSLR---IIIQStPSGEQYLPVAHTCYNLLDLPKYSSKEILSARLVQAIDHYEGFSL 1049
           ********************...7888856777**************************************97 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MLCWGYSSYG QPGIGSNLQV IIPEPQVYGF IHDRNVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHDC EGSKPEQIGA LAGQHIVHVA CGESHSVALS DQGQLFSWGA GSDGQLGLTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTATGCT GGGGCTACTC GTCTTATGGA CAGCCTGGGA TAGGTAGCAA CCTCCAGGTC 60
ATCATTCCTG AGCCACAGGT GTATGGGTTC ATCCACGATA GAAATGTCAA GGAGGTGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	88.11	0.00e+00	1860.00
IUUC-Apl-003535	Anas platyrhynchos	98.00	0.00e+00	2056.00
IUUC-Aca-005223	Anolis carolinensis	88.87	0.00e+00	1863.00
IUUC-Ame-010816	Astyanax mexicanus	67.04	0.00e+00	1163.00
IUUC-Bta-013373	Bos taurus	88.30	0.00e+00	1865.00
IUUC-Cel-018150	Caenorhabditis elegans	34.04	2.00e-153	536.00
IUUC-Cja-019609	Callithrix jacchus	88.01	0.00e+00	1856.00
IUUC-Cfa-021071	Canis familiaris	88.11	0.00e+00	1852.00
IUUC-Cpo-021548	Cavia porcellus	87.35	0.00e+00	1845.00
IUUC-Csa-023987	Chlorocebus sabaeus	88.39	0.00e+00	1861.00
IUUC-Cho-024325	Choloepus hoffmanni	90.22	0.00e+00	1102.00
IUUC-Dre-027472	Danio rerio	67.43	0.00e+00	1404.00
IUUC-Dno-029241	Dasypus novemcinctus	87.65	0.00e+00	1846.00
IUUC-Dor-030672	Dipodomys ordii	81.53	0.00e+00	988.00
IUUC-Ete-032642	Echinops telfairi	83.63	0.00e+00	1697.00
IUUC-Eca-033646	Equus caballus	88.39	0.00e+00	1862.00
IUUC-Eeu-035098	Erinaceus europaeus	77.01	0.00e+00	1229.00
IUUC-Fal-036952	Ficedula albicollis	99.05	0.00e+00	2074.00
IUUC-Gmo-039297	Gadus morhua	65.75	0.00e+00	1329.00
IUUC-Gga-040591	Gallus gallus	96.96	0.00e+00	2031.00
IUUC-Gac-041741	Gasterosteus aculeatus	66.07	0.00e+00	1379.00
IUUC-Ggo-044769	Gorilla gorilla	87.93	0.00e+00	1853.00
IUUC-Hsa-046066	Homo sapiens	88.20	0.00e+00	1858.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	87.93	0.00e+00	1853.00
IUUC-Lch-050301	Latimeria chalumnae	74.22	0.00e+00	1612.00
IUUC-Loc-052803	Lepisosteus oculatus	67.66	0.00e+00	1444.00
IUUC-Laf-053364	Loxodonta africana	88.20	0.00e+00	1856.00
IUUC-Mcc-054930	Macaca mulatta	88.30	0.00e+00	1861.00
IUUC-Meu-056274	Macropus eugenii	75.60	0.00e+00	819.00
IUUC-Mtr-058277	Medicago truncatula	38.24	2.00e-52	199.00
IUUC-Mga-059563	Meleagris gallopavo	97.62	0.00e+00	2047.00
IUUC-Mmr-060792	Microcebus murinus	87.16	0.00e+00	1818.00
IUUC-Mdo-062195	Monodelphis domestica	89.92	0.00e+00	1890.00
IUUC-Mmu-063855	Mus musculus	86.39	0.00e+00	1831.00
IUUC-Mpu-066308	Mustela putorius furo	88.39	0.00e+00	1860.00
IUUC-Mlu-066927	Myotis lucifugus	88.11	0.00e+00	1854.00
IUUC-Nle-070090	Nomascus leucogenys	88.20	0.00e+00	1860.00
IUUC-Opr-070891	Ochotona princeps	77.45	0.00e+00	1574.00
IUUC-Ont-072201	Oreochromis niloticus	65.00	0.00e+00	1341.00
IUUC-Ocu-074770	Oryctolagus cuniculus	88.68	0.00e+00	1864.00
IUUC-Ola-086550	Oryzias latipes	65.47	0.00e+00	1379.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.43	2.00e-43	169.00
IUUC-Oga-088831	Otolemur garnettii	88.01	0.00e+00	1857.00
IUUC-Oar-090449	Ovis aries	88.39	0.00e+00	1859.00
IUUC-Pan-092135	Papio anubis	88.31	0.00e+00	1857.00
IUUC-Psi-093832	Pelodiscus sinensis	90.02	0.00e+00	1922.00
IUUC-Pfo-097268	Poecilia formosa	65.94	0.00e+00	1378.00
IUUC-Pab-098249	Pongo abelii	87.92	0.00e+00	1852.00
IUUC-Pca-100855	Procavia capensis	84.15	0.00e+00	1273.00
IUUC-Pva-102506	Pteropus vampyrus	80.61	0.00e+00	1630.00
IUUC-Rno-105242	Rattus norvegicus	86.39	0.00e+00	1871.00
IUUC-Sha-107186	Sarcophilus harrisii	86.73	0.00e+00	1153.00
IUUC-Sar-113612	Sorex araneus	90.28	0.00e+00	703.00
IUUC-Ssc-115473	Sus scrofa	87.63	0.00e+00	1847.00
IUUC-Tru-118077	Takifugu rubripes	65.09	0.00e+00	1315.00
IUUC-Tsy-119619	Tarsius syrichta	77.83	0.00e+00	1638.00
IUUC-Tni-120807	Tetraodon nigroviridis	65.32	0.00e+00	1341.00
IUUC-Tbe-127640	Tupaia belangeri	84.11	0.00e+00	1723.00
IUUC-Ttr-129172	Tursiops truncatus	87.44	0.00e+00	1840.00
IUUC-Vpa-130442	Vicugna pacos	73.66	0.00e+00	1485.00
IUUC-Xtr-132194	Xenopus tropicalis	71.82	0.00e+00	1412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence