iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138642.14	ENST00000380265.9	ENSP00000369617.5
ENSG00000138642.14	ENST00000264346.11	ENSP00000264346.7
ENSG00000138642.14	ENST00000504905.5	ENSP00000425504.1
ENSG00000138642.14	ENST00000502870.1	ENSP00000425060.1
ENSG00000138642.14	ENST00000273960.7	ENSP00000273960.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20133869

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	5.90e-91	307.0	695	1014

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            d+ k+l vef +E + + gGv++ef++++++e+ +p++g+f+y e ++++++p++ +     e+ ++F  +G+l+g++l++ ++ +lp+
   Q: 695  TDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKP----EKKRYFL-FGMLCGLSLFNLNVANLPF 779
           688899*************************************************9885....7889995.5****************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrl 182
           + ++yk+ll++k sledl+e+ p l ksl+e+++ a +di ++ l+++fs++     ++++++L+p+G +ipV ++Nk++Yv+++++y++
   Q: 780  PLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDA-LCIRFSIH----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIF 864
           ***********************************99999998.*****955....5779999*************************** PP
   S: 183  kegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgss 272
           + ++k  +e+f++Gf++v+++e+l+ F +eel + i G++++d+++++++ ky++gy++++p+iq Fw+++++++ +e+k+fL F+Tg++
   Q: 865  NVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRD 954
           ****************************************************************************************** PP
   S: 273  rlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           rl ++G+++++  +f +++  s+++ P+s TC n L LP+Ys++e ++e L++Ai++++gF
   Q: 955  RLHARGIQKME-IVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
           ***********.77888889****************************************9 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN SRGQLGRRGA 60
QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG AGSEGQLGIG EFKEISFTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTTGAA GTTCAGGCAG CGAGAGTTGA CATGGGGCCA GGGCTGCGCC CCTGGGGCGG 60
GTTGAAGACA GGGTGAGTCT CTTGATATTC AGGAAATCAT CGCGCACCCA GTCACCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0000209--P:protein polyubiquitination

KEGG

hsa:55008

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	73.16	0.00e+00	1410.00
IUUC-Aca-004663	Anolis carolinensis	46.88	0.00e+00	873.00
IUUC-Bta-013080	Bos taurus	73.73	0.00e+00	1459.00
IUUC-Cja-018891	Callithrix jacchus	86.85	0.00e+00	1764.00
IUUC-Cfa-020763	Canis familiaris	72.49	0.00e+00	1367.00
IUUC-Cpo-022346	Cavia porcellus	70.52	0.00e+00	1447.00
IUUC-Csa-023049	Chlorocebus sabaeus	95.29	0.00e+00	1998.00
IUUC-Dno-029093	Dasypus novemcinctus	76.42	0.00e+00	1560.00
IUUC-Eca-034098	Equus caballus	77.28	0.00e+00	1486.00
IUUC-Eeu-035028	Erinaceus europaeus	59.54	1.00e-167	584.00
IUUC-Fca-036283	Felis catus	74.52	0.00e+00	1439.00
IUUC-Ggo-045553	Gorilla gorilla	94.41	0.00e+00	1937.00
IUUC-Loc-052700	Lepisosteus oculatus	41.84	0.00e+00	802.00
IUUC-Laf-054433	Loxodonta africana	71.95	0.00e+00	1506.00
IUUC-Mcc-055014	Macaca mulatta	90.77	0.00e+00	1922.00
IUUC-Mdo-061839	Monodelphis domestica	57.28	0.00e+00	1055.00
IUUC-Mmu-064378	Mus musculus	66.31	0.00e+00	1306.00
IUUC-Mpu-066293	Mustela putorius furo	71.75	0.00e+00	1362.00
IUUC-Mlu-067407	Myotis lucifugus	73.11	0.00e+00	1436.00
IUUC-Nle-069978	Nomascus leucogenys	95.68	0.00e+00	2006.00
IUUC-Opr-070190	Ochotona princeps	60.31	0.00e+00	721.00
IUUC-Ocu-074640	Oryctolagus cuniculus	70.53	0.00e+00	874.00
IUUC-Oga-088780	Otolemur garnettii	71.47	0.00e+00	1431.00
IUUC-Oar-090307	Ovis aries	74.25	0.00e+00	1458.00
IUUC-Ptr-091567	Pan troglodytes	97.45	0.00e+00	2015.00
IUUC-Pan-091802	Papio anubis	89.82	0.00e+00	1865.00
IUUC-Pab-098024	Pongo abelii	78.56	0.00e+00	1546.00
IUUC-Pva-102382	Pteropus vampyrus	69.64	0.00e+00	1356.00
IUUC-Rno-105768	Rattus norvegicus	62.02	0.00e+00	1235.00
IUUC-Sha-106525	Sarcophilus harrisii	54.97	0.00e+00	1122.00
IUUC-Sar-113014	Sorex araneus	60.36	4.00e-158	551.00
IUUC-Tsy-119565	Tarsius syrichta	78.65	4.00e-176	612.00
IUUC-Vpa-130214	Vicugna pacos	71.98	0.00e+00	1308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence