iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000139323.13	ENST00000313546.7	ENSP00000323302.3
ENSG00000139323.13	ENST00000547496.5	ENSP00000447437.1
ENSG00000139323.13	ENST00000549504.1	ENSP00000450118.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.10e-55	182.1	143	178
UBD/Beta-Prp	9.60e-74	249.9	98	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           Ht +v+c +f +d +l+vs+s D+tik+WD++   +
   Q: 143  HTHWVRCAKFsPDgRLIVSCSEDKTIKIWDTTNKQC 178
           9**********999****************987665 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           +++h++++++v+fs d+++lat+s+d++ikvw++ ++ +l sl+ h+  v++ kfspdg ++v++seD+tik+wd  + +cv  ++     +
   Q: 98   FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
           45677777777777777777777777777777777777777777777777777777777777777777777777777777777777666666 PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
             ++f+psg  ++s+++d+t++vwd++ ++ l+   ++h+g vnc+++hp+gn+l+++s D+t+++ dl  g+l++tl+g ht++v  +sf+
   Q: 190  NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ-HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG-HTGPVFTVSFS 279
           667777777777777777777777777777777.7777777777777777777777777777777777777777777777.77777777777 PP
   S: 190  sngkelvsgsldgtvklwdlq 210
           + g+ ++sg+ d++v lw   
   Q: 280  KGGELFASGGADTQVLLWRTN 300
           777777777777777777654 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).

Protein Sequence
(Fasta)

MASATEDPVL ERYFKGHKAA ITSLDLSPNG KQLATASWDT FLMLWNFKPH ARAYRYVGHK 60
DVVTSVQFSP HGNLLASASR DRTVRLWIPD KRGKFSEFKA HTAPVRSVDF SADGQFLATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGGGAGG CGCTGCCGCT CTGGGCAGAC GGTTCCGGGA GCCGCACGGT CCCCTCTCCT 60
TCCCCATCCT CTCCCCTCCC CTCTCCGGGT TCCCCCACCC ACAGGAGCCT TGGGCCGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0970--Cilium biogenesis/degradation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0182--Cone-rod dystrophy
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0000922--C:spindle pole
GO:0008283--P:cell proliferation
GO:0060271--P:cilium assembly
GO:0001895--P:retina homeostasis

KEGG

hsa:282809

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002219	Ailuropoda melanoleuca	88.37	0.00e+00	818.00
IUUC-Apl-004219	Anas platyrhynchos	62.16	8.00e-162	563.00
IUUC-Aca-005197	Anolis carolinensis	58.59	5.00e-172	597.00
IUUC-Ame-011000	Astyanax mexicanus	56.08	3.00e-157	548.00
IUUC-Bta-012706	Bos taurus	89.73	0.00e+00	885.00
IUUC-Cja-019185	Callithrix jacchus	92.00	0.00e+00	884.00
IUUC-Cfa-021274	Canis familiaris	90.27	0.00e+00	882.00
IUUC-Cpo-022351	Cavia porcellus	84.23	0.00e+00	856.00
IUUC-Csa-023032	Chlorocebus sabaeus	92.68	0.00e+00	885.00
IUUC-Cho-024508	Choloepus hoffmanni	79.76	0.00e+00	676.00
IUUC-Dre-028703	Danio rerio	56.72	4.00e-156	544.00
IUUC-Dno-028915	Dasypus novemcinctus	89.41	0.00e+00	835.00
IUUC-Dor-030306	Dipodomys ordii	74.38	0.00e+00	646.00
IUUC-Dme-032182	Drosophila melanogaster	45.85	2.00e-80	292.00
IUUC-Ete-032353	Echinops telfairi	73.65	0.00e+00	682.00
IUUC-Eca-034136	Equus caballus	91.24	0.00e+00	832.00
IUUC-Eeu-034611	Erinaceus europaeus	79.59	4.00e-180	624.00
IUUC-Fca-036205	Felis catus	89.22	0.00e+00	779.00
IUUC-Fal-036947	Ficedula albicollis	53.70	4.00e-138	484.00
IUUC-Gga-040847	Gallus gallus	60.17	2.00e-162	565.00
IUUC-Ggo-045194	Gorilla gorilla	99.58	0.00e+00	980.00
IUUC-Itr-048943	Ictidomys tridecemlineatus	87.67	0.00e+00	820.00
IUUC-Lch-050067	Latimeria chalumnae	59.09	6.00e-172	597.00
IUUC-Loc-052409	Lepisosteus oculatus	57.84	2.00e-163	568.00
IUUC-Laf-053428	Loxodonta africana	89.43	0.00e+00	855.00
IUUC-Mcc-054772	Macaca mulatta	98.54	0.00e+00	965.00
IUUC-Meu-056496	Macropus eugenii	73.98	4.00e-165	574.00
IUUC-Mga-059276	Meleagris gallopavo	59.92	1.00e-165	575.00
IUUC-Mmr-061525	Microcebus murinus	90.79	0.00e+00	897.00
IUUC-Mdo-062351	Monodelphis domestica	69.94	0.00e+00	724.00
IUUC-Mmu-063834	Mus musculus	82.01	0.00e+00	822.00
IUUC-Mpu-066453	Mustela putorius furo	86.82	0.00e+00	850.00
IUUC-Mlu-067909	Myotis lucifugus	88.09	0.00e+00	803.00
IUUC-Nle-069206	Nomascus leucogenys	98.12	0.00e+00	983.00
IUUC-Opr-070566	Ochotona princeps	77.59	0.00e+00	743.00
IUUC-Oan-073726	Ornithorhynchus anatinus	66.82	1.00e-172	599.00
IUUC-Ocu-074639	Oryctolagus cuniculus	91.21	0.00e+00	903.00
IUUC-Ola-086913	Oryzias latipes	52.63	4.00e-146	511.00
IUUC-Oga-088061	Otolemur garnettii	91.62	0.00e+00	679.00
IUUC-Oar-090228	Ovis aries	84.75	0.00e+00	873.00
IUUC-Ptr-091420	Pan troglodytes	99.79	0.00e+00	982.00
IUUC-Pan-092228	Papio anubis	98.33	0.00e+00	963.00
IUUC-Psi-093309	Pelodiscus sinensis	62.45	2.00e-169	588.00
IUUC-Pab-098109	Pongo abelii	98.95	0.00e+00	972.00
IUUC-Pca-101012	Procavia capensis	68.41	0.00e+00	633.00
IUUC-Pva-102712	Pteropus vampyrus	89.96	0.00e+00	884.00
IUUC-Rno-105260	Rattus norvegicus	81.17	0.00e+00	819.00
IUUC-Sar-113446	Sorex araneus	76.99	0.00e+00	762.00
IUUC-Ssc-115794	Sus scrofa	91.87	0.00e+00	717.00
IUUC-Tgu-116770	Taeniopygia guttata	55.44	4.00e-142	498.00
IUUC-Tru-117968	Takifugu rubripes	55.23	5.00e-150	524.00
IUUC-Tsy-119316	Tarsius syrichta	78.60	0.00e+00	704.00
IUUC-Tbe-128071	Tupaia belangeri	87.56	0.00e+00	774.00
IUUC-Ttr-129267	Tursiops truncatus	89.54	0.00e+00	884.00
IUUC-Vpa-130823	Vicugna pacos	82.14	8.00e-176	610.00
IUUC-Xtr-131768	Xenopus tropicalis	58.47	6.00e-166	577.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence