iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000139990.17	ENST00000341516.9	ENSP00000341351.5
ENSG00000139990.17	ENST00000557386.5	ENSP00000451845.1
ENSG00000139990.17	ENST00000556111.1	ENSP00000452077.1
ENSG00000139990.17	ENST00000389997.10	ENSP00000374647.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-27	94.6	141	173

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           H+d v++l+    +d++++s+sdDg + +WD+r
   Q: 141  HEDAVYGLSVspvNDNIFASSSDDGRVLIWDIR 173
           9*******9999999****************87 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE 60
FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGAAGCCG CGAACGCCGC CGAGTGTCTG CACACCTCGC TCTGCCTGCC ATGGCTGGTT 60
AAAGAACCAT CCGGATCGCA GCGCGGGGGG AGGGCCGGGT GGGGGGAGCA GCGGCCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005739--C:mitochondrion
GO:0016567--P:protein ubiquitination

KEGG

hsa:8816

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001497	Ailuropoda melanoleuca	93.03	0.00e+00	1543.00
IUUC-Apl-003432	Anas platyrhynchos	72.36	0.00e+00	1095.00
IUUC-Aca-005069	Anolis carolinensis	68.65	0.00e+00	1031.00
IUUC-Ame-011063	Astyanax mexicanus	85.81	0.00e+00	748.00
IUUC-Bta-013013	Bos taurus	92.69	0.00e+00	1507.00
IUUC-Cel-018265	Caenorhabditis elegans	30.94	5.00e-33	136.00
IUUC-Cja-018816	Callithrix jacchus	98.20	0.00e+00	1791.00
IUUC-Cfa-020397	Canis familiaris	94.09	0.00e+00	1618.00
IUUC-Cpo-021999	Cavia porcellus	91.79	0.00e+00	1474.00
IUUC-Csa-024256	Chlorocebus sabaeus	98.51	0.00e+00	1791.00
IUUC-Cho-024707	Choloepus hoffmanni	88.44	0.00e+00	1401.00
IUUC-Cin-025728	Ciona intestinalis	46.67	6.00e-53	200.00
IUUC-Dre-027683	Danio rerio	87.50	0.00e+00	761.00
IUUC-Dno-029603	Dasypus novemcinctus	94.83	0.00e+00	1648.00
IUUC-Dme-031660	Drosophila melanogaster	45.34	2.00e-92	333.00
IUUC-Ete-032701	Echinops telfairi	86.73	0.00e+00	1377.00
IUUC-Eca-033345	Equus caballus	94.34	0.00e+00	1533.00
IUUC-Eeu-034973	Erinaceus europaeus	88.07	0.00e+00	904.00
IUUC-Fca-036007	Felis catus	94.40	0.00e+00	1647.00
IUUC-Fal-036759	Ficedula albicollis	71.30	0.00e+00	1075.00
IUUC-Gmo-039095	Gadus morhua	84.88	0.00e+00	761.00
IUUC-Gga-040850	Gallus gallus	96.42	2.00e-159	554.00
IUUC-Ggo-045451	Gorilla gorilla	99.58	0.00e+00	1778.00
IUUC-Itr-048562	Ictidomys tridecemlineatus	92.60	0.00e+00	1065.00
IUUC-Lch-049676	Latimeria chalumnae	59.50	0.00e+00	963.00
IUUC-Loc-052200	Lepisosteus oculatus	76.46	0.00e+00	756.00
IUUC-Laf-053783	Loxodonta africana	93.86	0.00e+00	1510.00
IUUC-Mcc-055495	Macaca mulatta	98.51	0.00e+00	1793.00
IUUC-Meu-056044	Macropus eugenii	79.79	0.00e+00	1221.00
IUUC-Mga-059650	Meleagris gallopavo	71.02	0.00e+00	931.00
IUUC-Mvi-060289	Microbotryum violaceum	26.45	4.00e-13	69.70
IUUC-Mdo-063059	Monodelphis domestica	82.82	0.00e+00	1385.00
IUUC-Mmu-063315	Mus musculus	90.81	0.00e+00	1560.00
IUUC-Mpu-066563	Mustela putorius furo	91.45	0.00e+00	1362.00
IUUC-Mlu-067408	Myotis lucifugus	92.12	0.00e+00	1456.00
IUUC-Nle-069574	Nomascus leucogenys	99.26	0.00e+00	1809.00
IUUC-Opr-070491	Ochotona princeps	81.50	0.00e+00	1392.00
IUUC-Ont-071270	Oreochromis niloticus	84.79	0.00e+00	773.00
IUUC-Oan-073632	Ornithorhynchus anatinus	78.48	0.00e+00	847.00
IUUC-Ocu-074329	Oryctolagus cuniculus	92.60	0.00e+00	1633.00
IUUC-Ola-087017	Oryzias latipes	84.62	3.00e-143	500.00
IUUC-Oga-088295	Otolemur garnettii	91.23	0.00e+00	1633.00
IUUC-Oar-089609	Ovis aries	88.70	0.00e+00	1468.00
IUUC-Ptr-090891	Pan troglodytes	99.79	0.00e+00	1734.00
IUUC-Pan-092220	Papio anubis	98.38	0.00e+00	1755.00
IUUC-Psi-093097	Pelodiscus sinensis	60.34	3.00e-160	559.00
IUUC-Pfo-096844	Poecilia formosa	82.92	0.00e+00	629.00
IUUC-Pab-098512	Pongo abelii	99.47	0.00e+00	1813.00
IUUC-Pca-100999	Procavia capensis	87.57	0.00e+00	1432.00
IUUC-Pva-102524	Pteropus vampyrus	93.88	0.00e+00	1622.00
IUUC-Pgr-103528	Puccinia graminis	24.57	1.00e-29	124.00
IUUC-Rno-104861	Rattus norvegicus	91.66	0.00e+00	1607.00
IUUC-Sha-106554	Sarcophilus harrisii	95.98	2.00e-128	451.00
IUUC-Sar-113644	Sorex araneus	84.51	1.00e-166	580.00
IUUC-Sre-114948	Sporisorium reilianum	27.12	2.00e-22	101.00
IUUC-Ssc-115431	Sus scrofa	100.00	5.00e-79	285.00
IUUC-Tgu-117355	Taeniopygia guttata	74.05	0.00e+00	1187.00
IUUC-Tru-118672	Takifugu rubripes	81.70	0.00e+00	748.00
IUUC-Tni-120215	Tetraodon nigroviridis	74.49	0.00e+00	670.00
IUUC-Ttr-128965	Tursiops truncatus	96.67	0.00e+00	1041.00
IUUC-Vpa-130586	Vicugna pacos	90.17	0.00e+00	1406.00
IUUC-Xtr-132611	Xenopus tropicalis	59.26	0.00e+00	936.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence