iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140395.8	ENST00000558453.5	ENSP00000453118.1
ENSG00000140395.8	ENST00000560807.5	ENSP00000455689.1
ENSG00000140395.8	ENST00000558311.5	ENSP00000453801.1
ENSG00000140395.8	ENST00000558459.5	ENSP00000453024.1
ENSG00000140395.8	ENST00000559848.1	ENSP00000453589.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-44	149.1	230	269
UBD/Beta-Prp	1.90e-74	252.2	12	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+++v  +af +d t++vs+s D+++kvWD+ t +++++
   Q: 230  GHASWVLNVAFcPDdTHFVSSSSDKSVKVWDVGTRTCVHT 269
           8***********777*****************99999875 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           +++h++ i +v++    +++++ ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ ++ 
   Q: 12   EQAHDDAIWSVAWgtnkKENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID 103
           567788888899998888999********************99999********************************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           +   ++++l+fsp++++l++G+h+  ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g h  ++
   Q: 104  AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG-HAMPI 193
           ***************************************.*********************************************9.***** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsf 275
           +sl+f+++++ lv++s+dg++k++d+q+ +   tl gh ++v+ v+f+p+d+++vs ssD+s+++Wd+ ++++++t+  h+++v+ v++ + 
   Q: 194  RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY-NG 284
           *****************************************************************************************.99 PP
   S: 276  gdnvlvlgsedskvniwkl 294
           +++++v++++d++++i+++
   Q: 285  NGSKIVSVGDDQEIHIYDC 303
           9****************98 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

Protein Sequence
(Fasta)

MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATTTCCAA CTACCACTCC TCTGGAAGCA GGACCTGGCT TCCTCCCTCC TCTCTCCGCC 60
CACCCTCGTC GGCGTCTGCC CCGCGCCCGC CATAGCGACG GCAACGGGCG CTGCGGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0043928--P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:80349

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000774	Aegilops tauschii	33.93	1.00e-47	183.00
IUUC-Aml-002245	Ailuropoda melanoleuca	98.69	5.00e-168	583.00
IUUC-Atr-003142	Amborella trichopoda	51.55	2.00e-38	152.00
IUUC-Apl-003179	Anas platyrhynchos	91.15	2.00e-157	548.00
IUUC-Aca-004880	Anolis carolinensis	88.20	3.00e-157	547.00
IUUC-Aly-005956	Arabidopsis lyrata	37.82	1.00e-55	209.00
IUUC-Ath-007230	Arabidopsis thaliana	37.50	2.00e-51	196.00
IUUC-Acl-008297	Aspergillus clavatus	28.88	6.00e-25	108.00
IUUC-Ang-009702	Aspergillus niger	29.90	8.00e-30	124.00
IUUC-Ame-011511	Astyanax mexicanus	83.71	8.00e-149	519.00
IUUC-Bgr-012189	Blumeria graminis	30.82	1.00e-28	120.00
IUUC-Bta-012936	Bos taurus	99.02	2.00e-168	584.00
IUUC-Bdi-015020	Brachypodium distachyon	37.59	4.00e-47	181.00
IUUC-Bol-016345	Brassica oleracea	38.46	1.00e-56	213.00
IUUC-Bra-017323	Brassica rapa	38.46	7.00e-57	214.00
IUUC-Cja-019961	Callithrix jacchus	100.00	8.00e-170	589.00
IUUC-Cfa-020862	Canis familiaris	98.36	3.00e-167	580.00
IUUC-Cpo-021356	Cavia porcellus	99.01	7.00e-166	576.00
IUUC-Cre-022602	Chlamydomonas reinhardtii	41.58	2.00e-57	216.00
IUUC-Csa-024067	Chlorocebus sabaeus	99.67	4.00e-169	587.00
IUUC-Cho-024421	Choloepus hoffmanni	83.84	9.00e-83	299.00
IUUC-Cin-025261	Ciona intestinalis	64.59	5.00e-116	410.00
IUUC-Cgl-026446	Colletotrichum gloeosporioides	28.30	1.00e-28	120.00
IUUC-Cne-026846	Cryptococcus neoformans	29.45	7.00e-25	108.00
IUUC-Dre-027706	Danio rerio	65.57	7.00e-110	390.00
IUUC-Dno-029084	Dasypus novemcinctus	99.02	1.00e-167	582.00
IUUC-Dor-030353	Dipodomys ordii	83.33	1.00e-123	435.00
IUUC-Dse-031348	Dothistroma septosporum	29.08	2.00e-26	112.00
IUUC-Dme-031836	Drosophila melanogaster	52.31	9.00e-88	317.00
IUUC-Ete-032261	Echinops telfairi	96.39	2.00e-162	564.00
IUUC-Eca-034231	Equus caballus	91.48	3.00e-153	534.00
IUUC-Eeu-034828	Erinaceus europaeus	97.94	3.00e-157	547.00
IUUC-Fca-036569	Felis catus	99.02	7.00e-168	582.00
IUUC-Fal-037469	Ficedula albicollis	93.11	2.00e-161	561.00
IUUC-Fox-038047	Fusarium oxysporum	33.00	4.00e-29	122.00
IUUC-Gmo-039579	Gadus morhua	83.61	8.00e-146	509.00
IUUC-Gga-040808	Gallus gallus	93.49	6.00e-154	536.00
IUUC-Gac-042100	Gasterosteus aculeatus	83.93	5.00e-147	513.00
IUUC-Gma-044408	Glycine max	40.94	8.00e-60	223.00
IUUC-Ggo-045227	Gorilla gorilla	100.00	8.00e-170	589.00
IUUC-Hvu-047591	Hordeum vulgare	37.97	1.00e-49	190.00
IUUC-Itr-048741	Ictidomys tridecemlineatus	99.67	4.00e-169	587.00
IUUC-Lch-049549	Latimeria chalumnae	83.61	8.00e-147	512.00
IUUC-Lpe-050746	Leersia perrieri	38.59	4.00e-48	184.00
IUUC-Loc-052540	Lepisosteus oculatus	86.56	2.00e-148	518.00
IUUC-Lma-052992	Leptosphaeria maculans	28.14	4.00e-27	115.00
IUUC-Laf-053907	Loxodonta africana	99.67	4.00e-169	587.00
IUUC-Mcc-055828	Macaca mulatta	93.54	1.00e-165	575.00
IUUC-Meu-056075	Macropus eugenii	94.51	4.00e-135	473.00
IUUC-Mtr-057728	Medicago truncatula	40.71	2.00e-56	213.00
IUUC-Mga-059872	Meleagris gallopavo	93.44	5.00e-162	563.00
IUUC-Mvi-060564	Microbotryum violaceum	32.11	1.00e-29	124.00
IUUC-Mmr-060985	Microcebus murinus	99.66	4.00e-161	560.00
IUUC-Mdo-062758	Monodelphis domestica	90.46	1.00e-158	551.00
IUUC-Mmu-063580	Mus musculus	97.38	2.00e-166	578.00
IUUC-Mac-064880	Musa acuminata	40.19	7.00e-58	217.00
IUUC-Mpu-066577	Mustela putorius furo	98.03	2.00e-166	578.00
IUUC-Nle-069573	Nomascus leucogenys	100.00	8.00e-170	589.00
IUUC-Opr-070216	Ochotona princeps	97.67	2.00e-164	571.00
IUUC-Ont-071981	Oreochromis niloticus	85.25	9.00e-150	522.00
IUUC-Oan-073223	Ornithorhynchus anatinus	93.94	1.00e-107	381.00
IUUC-Ocu-074199	Oryctolagus cuniculus	84.92	2.00e-139	488.00
IUUC-Oba-075255	Oryza barthii	40.00	1.00e-41	163.00
IUUC-Obr-076168	Oryza brachyantha	47.20	1.00e-35	143.00
IUUC-Ogl-077777	Oryza glaberrima	38.39	8.00e-49	187.00
IUUC-Ogu-078780	Oryza glumaepatula	38.39	8.00e-49	187.00
IUUC-Oin-079228	Oryza indica	38.39	2.00e-51	196.00
IUUC-Olo-080617	Oryza longistaminata	45.77	3.00e-29	120.00
IUUC-Ome-081421	Oryza meridionalis	38.39	5.00e-48	184.00
IUUC-Oni-082997	Oryza nivara	38.39	2.00e-51	196.00
IUUC-Opu-083931	Oryza punctata	38.71	8.00e-49	187.00
IUUC-Oru-084645	Oryza rufipogon	38.39	8.00e-49	187.00
IUUC-Osa-085842	Oryza sativa	38.39	2.00e-51	196.00
IUUC-Ola-086696	Oryzias latipes	84.92	1.00e-145	508.00
IUUC-Olu-087643	Ostreococcus lucimarinus	39.91	1.00e-41	162.00
IUUC-Oga-088272	Otolemur garnettii	97.70	3.00e-165	573.00
IUUC-Oar-089416	Ovis aries	99.02	2.00e-168	584.00
IUUC-Ptr-090944	Pan troglodytes	100.00	8.00e-170	589.00
IUUC-Pan-091861	Papio anubis	100.00	8.00e-170	589.00
IUUC-Psi-093750	Pelodiscus sinensis	93.77	4.00e-161	560.00
IUUC-Pma-094608	Petromyzon marinus	79.68	5.00e-135	473.00
IUUC-Pno-094832	Phaeosphaeria nodorum	32.59	3.00e-26	112.00
IUUC-Ppa-095737	Physcomitrella patens	40.38	1.00e-56	213.00
IUUC-Pfo-096479	Poecilia formosa	85.90	8.00e-144	503.00
IUUC-Pab-098179	Pongo abelii	100.00	8.00e-170	589.00
IUUC-Pop-099532	Populus trichocarpa	40.91	4.00e-56	211.00
IUUC-Pca-100664	Procavia capensis	76.45	8.00e-106	376.00
IUUC-Ppe-102056	Prunus persica	40.26	5.00e-58	218.00
IUUC-Pva-102859	Pteropus vampyrus	99.02	6.00e-168	583.00
IUUC-Pte-104236	Pyrenophora teres	35.56	2.00e-25	109.00
IUUC-Rno-105826	Rattus norvegicus	97.05	8.00e-166	575.00
IUUC-Sha-106660	Sarcophilus harrisii	92.03	9.00e-153	532.00
IUUC-Sja-107800	Schizosaccharomyces japonicus	33.22	6.00e-36	144.00
IUUC-Spo-108244	Schizosaccharomyces pombe	31.39	4.00e-35	141.00
IUUC-Smo-109234	Selaginella moellendorffii	42.81	5.00e-61	228.00
IUUC-Sit-110048	Setaria italica	36.86	1.00e-40	160.00
IUUC-Sly-111618	Solanum lycopersicum	38.46	4.00e-52	198.00
IUUC-Stu-112543	Solanum tuberosum	38.78	3.00e-55	209.00
IUUC-Sar-113743	Sorex araneus	78.36	4.00e-130	457.00
IUUC-Sbi-114309	Sorghum bicolor	38.57	8.00e-42	164.00
IUUC-Ssc-115560	Sus scrofa	93.44	4.00e-155	540.00
IUUC-Tgu-117300	Taeniopygia guttata	93.44	8.00e-162	562.00
IUUC-Tru-117933	Takifugu rubripes	84.59	4.00e-149	520.00
IUUC-Tsy-119574	Tarsius syrichta	88.85	3.00e-145	507.00
IUUC-Tni-120191	Tetraodon nigroviridis	87.34	7.00e-113	399.00
IUUC-Tca-120983	Theobroma cacao	40.13	2.00e-57	216.00
IUUC-Tae-124056	Triticum aestivum	36.16	1.00e-49	190.00
IUUC-Tur-126711	Triticum urartu	36.05	1.00e-48	186.00
IUUC-Tme-127066	Tuber melanosporum	33.83	6.00e-34	138.00
IUUC-Tbe-127802	Tupaia belangeri	99.02	7.00e-168	582.00
IUUC-Ttr-128861	Tursiops truncatus	98.11	2.00e-56	212.00
IUUC-Vda-129720	Verticillium dahliae	29.27	7.00e-23	101.00
IUUC-Vpa-130618	Vicugna pacos	95.55	1.00e-135	475.00
IUUC-Vvi-130981	Vitis vinifera	40.38	9.00e-56	210.00
IUUC-Xtr-132460	Xenopus tropicalis	85.90	7.00e-146	509.00
IUUC-Xma-134154	Xiphophorus maculatus	85.90	6.00e-144	503.00
IUUC-Yli-134554	Yarrowia lipolytica	27.90	4.00e-20	92.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence