iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028452

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CR391977

Gene Name

usp3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000045641.6	ENSDART00000155698.1	ENSDARP00000129176.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.70e-102	341.7	163	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+ + ++++e             ++  + +++ +++ +l+++++k + +lw+++++a+sp +l+ +++
   Q: 163  TGLRNLGNTCFMNAILQSLSNIQVFSCYFKElpsvalrsgktAGRRMYHTRSQGDSSVSLVEEFRKTLCSLWQGSQTAFSPDALFYVIW 251
           7******************************888887766664444444445588899******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Efl++lld+l++e++ +kn + +    +d +  + ++++   + ++++++ +F+g l++++ cl c+++s +++
   Q: 252  KIMPSFRGYQQQDAHEFLRYLLDHLHREMQGNKNGSPSPPVTSD-EPNHASESKCFINGTSTIVTSVFGGVLQNEVYCLICGTESRKFD 339
           *****************************665555555444444.3344445677889999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++   k++         +l+dcL+sft  eel++ + y c kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 340  PFLDLSLDIPNQFRIKTTkdqepgptcTLSDCLRSFTDLEELDETELYMCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHW--TAFLRN 426
           **********8876655578899999*****************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefp   Ld+++++ +pe++  e++ Y+L avvvH+G +++sGHY+ay ++ +g+W++f+Ds+Vt v+ee vl+   ++aY+lf
   Q: 427  KVDTYVEFPMCgLDMKSYLLEPENSLPERCLYDLAAVVVHHGsGIGSGHYTAYGRH-EGQWYHFNDSTVTLVSEEAVLK---AKAYILF 511
           ********************************************************.**********************...******* PP
   S: 335  Ykr 337
           Y++
   Q: 512  YTE 514
           *86 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MECPHLNSSV CMTVDLTRFP NGSPSSWCCS VCRSNKSPWV CLTCMNVHCG RYVNGHAKKH 60
FEEIEAPGCS QRKPDREKLR EKGQQHSVCM DCNSYSTFCY KCDEFVVNDT KLGHVQRVRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGTTGGTC CTTCCCGCCG TAAAACCGAA GAAGAAGTTC TCTTTTTAGA CAGCATTTTT 60
GATGTATAGT TAGGGAACTT GGTAGGTTTT GAAACAGCCT GAGTCTGTGC GTGCATGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:569679

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	73.66	0.00e+00	759.00
IUUC-Apl-003358	Anas platyrhynchos	74.49	0.00e+00	691.00
IUUC-Aca-004454	Anolis carolinensis	74.08	0.00e+00	675.00
IUUC-Aor-010035	Aspergillus oryzae	39.06	2.00e-42	166.00
IUUC-Ame-011544	Astyanax mexicanus	82.50	0.00e+00	823.00
IUUC-Bta-012738	Bos taurus	74.10	0.00e+00	719.00
IUUC-Cel-018186	Caenorhabditis elegans	37.25	1.00e-60	227.00
IUUC-Cja-018893	Callithrix jacchus	73.66	0.00e+00	718.00
IUUC-Cfa-020607	Canis familiaris	73.66	0.00e+00	721.00
IUUC-Cpo-021828	Cavia porcellus	74.43	0.00e+00	719.00
IUUC-Csa-023884	Chlorocebus sabaeus	75.29	2.00e-170	592.00
IUUC-Cho-024863	Choloepus hoffmanni	66.79	2.00e-179	621.00
IUUC-Dno-029531	Dasypus novemcinctus	73.28	0.00e+00	664.00
IUUC-Dor-030913	Dipodomys ordii	65.28	2.00e-131	462.00
IUUC-Ete-032611	Echinops telfairi	69.08	0.00e+00	677.00
IUUC-Eca-033622	Equus caballus	73.48	0.00e+00	669.00
IUUC-Eeu-035268	Erinaceus europaeus	70.99	1.00e-176	612.00
IUUC-Fca-035801	Felis catus	73.28	0.00e+00	679.00
IUUC-Fal-036749	Ficedula albicollis	74.14	0.00e+00	674.00
IUUC-Gmo-039598	Gadus morhua	76.65	0.00e+00	783.00
IUUC-Gga-040883	Gallus gallus	74.49	0.00e+00	677.00
IUUC-Gac-042235	Gasterosteus aculeatus	75.71	0.00e+00	771.00
IUUC-Ggo-044767	Gorilla gorilla	69.90	0.00e+00	632.00
IUUC-Hsa-046581	Homo sapiens	73.66	0.00e+00	736.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	73.85	0.00e+00	722.00
IUUC-Lch-049732	Latimeria chalumnae	75.57	0.00e+00	773.00
IUUC-Loc-052371	Lepisosteus oculatus	77.82	0.00e+00	788.00
IUUC-Laf-054565	Loxodonta africana	73.85	0.00e+00	720.00
IUUC-Mcc-055522	Macaca mulatta	73.66	0.00e+00	736.00
IUUC-Meu-056754	Macropus eugenii	64.67	6.00e-133	467.00
IUUC-Mga-060095	Meleagris gallopavo	70.00	3.00e-140	491.00
IUUC-Mmr-060839	Microcebus murinus	73.66	0.00e+00	719.00
IUUC-Mdo-062339	Monodelphis domestica	76.09	9.00e-173	599.00
IUUC-Mmu-063638	Mus musculus	73.66	0.00e+00	703.00
IUUC-Mpu-066647	Mustela putorius furo	75.40	1.00e-171	596.00
IUUC-Mlu-067921	Myotis lucifugus	72.67	0.00e+00	692.00
IUUC-Nle-069752	Nomascus leucogenys	74.05	0.00e+00	737.00
IUUC-Opr-070636	Ochotona princeps	67.75	3.00e-166	578.00
IUUC-Ont-071638	Oreochromis niloticus	77.71	0.00e+00	725.00
IUUC-Oan-073417	Ornithorhynchus anatinus	69.66	0.00e+00	682.00
IUUC-Ocu-074620	Oryctolagus cuniculus	75.05	0.00e+00	729.00
IUUC-Ola-087281	Oryzias latipes	77.23	0.00e+00	631.00
IUUC-Olu-087697	Ostreococcus lucimarinus	38.22	3.00e-51	195.00
IUUC-Oga-088448	Otolemur garnettii	73.66	0.00e+00	732.00
IUUC-Oar-090132	Ovis aries	74.43	0.00e+00	724.00
IUUC-Ptr-090696	Pan troglodytes	73.54	0.00e+00	688.00
IUUC-Pan-092124	Papio anubis	73.47	0.00e+00	733.00
IUUC-Psi-093801	Pelodiscus sinensis	75.86	5.00e-172	597.00
IUUC-Pma-094472	Petromyzon marinus	71.24	6.00e-91	326.00
IUUC-Pfo-096330	Poecilia formosa	77.74	0.00e+00	799.00
IUUC-Pab-098191	Pongo abelii	73.66	0.00e+00	736.00
IUUC-Pca-100341	Procavia capensis	72.13	9.00e-160	556.00
IUUC-Pva-103177	Pteropus vampyrus	72.90	0.00e+00	709.00
IUUC-Rno-105048	Rattus norvegicus	73.66	0.00e+00	702.00
IUUC-Sha-107429	Sarcophilus harrisii	73.45	0.00e+00	673.00
IUUC-Sar-113024	Sorex araneus	73.57	0.00e+00	631.00
IUUC-Ssc-115749	Sus scrofa	69.89	2.00e-114	404.00
IUUC-Tgu-117277	Taeniopygia guttata	73.68	0.00e+00	682.00
IUUC-Tru-117844	Takifugu rubripes	78.89	0.00e+00	806.00
IUUC-Tsy-119456	Tarsius syrichta	71.60	0.00e+00	666.00
IUUC-Tni-120251	Tetraodon nigroviridis	76.39	0.00e+00	835.00
IUUC-Tbe-127423	Tupaia belangeri	70.23	0.00e+00	662.00
IUUC-Ttr-128401	Tursiops truncatus	68.15	6.00e-173	600.00
IUUC-Vpa-130549	Vicugna pacos	62.61	4.00e-120	424.00
IUUC-Xtr-131892	Xenopus tropicalis	69.74	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence