iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033622

UUCD1 version

UUC-EqC-01035

Ensembl Protein ID

ENSECAP00000014854.1

UniProt Accession

F6WN00; F6WN00_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016660.1	ENSECAT00000018219.1	ENSECAP00000014854.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-100	336.1	131	482
UBD/ZnF/ZnF_UBP	1.40e-25	89.5	3	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 131  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 219
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls + ++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 220  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSPS-NKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 307
           *****************************7755555555555555555554.578899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 308  PFLDLSLDIPSQFRNKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 394
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++e++v++   ++aY+lf
   Q: 395  KVDTYVEFPLRgLDMKCYLLEPENSGPENCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEDTVVK---AKAYILF 479
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 480  YVE 482
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 5    vcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           vc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 3    VCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQTPLtnhkksekqdkaqhtvCMDCSSYSTYCYRCDDFVVN 76
           6***********************************************************************85 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LLVCRSNKSP WVCLTCSSVH CGRYVNGHAK KHYEDAQTPL TNHKKSEKQD KAQHTVCMDC 60
SSYSTYCYRC DDFVVNDTKL GLVQKVREHL QNLENSAFTA DRHRKRKLLE NSSLNSKLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTATTAGTGT GCCGGTCCAA CAAAAGCCCC TGGGTCTGTT TGACTTGTTC GAGTGTCCAC 60
TGTGGAAGGT AGGTGACATG CTTATTACCT CACTACCCTA AGTGCTTCTC TCAGTTTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	98.37	0.00e+00	895.00
IUUC-Apl-003358	Anas platyrhynchos	95.33	0.00e+00	901.00
IUUC-Aca-004454	Anolis carolinensis	92.74	0.00e+00	806.00
IUUC-Ame-011544	Astyanax mexicanus	76.80	0.00e+00	688.00
IUUC-Bta-012738	Bos taurus	98.37	0.00e+00	879.00
IUUC-Cel-018186	Caenorhabditis elegans	37.64	1.00e-55	210.00
IUUC-Cja-018893	Callithrix jacchus	97.96	0.00e+00	886.00
IUUC-Cfa-020607	Canis familiaris	98.98	0.00e+00	882.00
IUUC-Cpo-021828	Cavia porcellus	96.12	0.00e+00	856.00
IUUC-Csa-023884	Chlorocebus sabaeus	98.82	0.00e+00	780.00
IUUC-Cho-024863	Choloepus hoffmanni	88.57	0.00e+00	759.00
IUUC-Dre-028452	Danio rerio	73.48	0.00e+00	698.00
IUUC-Dno-029531	Dasypus novemcinctus	97.56	0.00e+00	876.00
IUUC-Dor-030913	Dipodomys ordii	89.22	4.00e-177	614.00
IUUC-Ete-032611	Echinops telfairi	91.43	0.00e+00	816.00
IUUC-Eeu-035268	Erinaceus europaeus	93.25	0.00e+00	805.00
IUUC-Fca-035801	Felis catus	98.37	0.00e+00	915.00
IUUC-Fal-036749	Ficedula albicollis	94.69	0.00e+00	850.00
IUUC-Gmo-039598	Gadus morhua	77.75	0.00e+00	725.00
IUUC-Gga-040883	Gallus gallus	95.53	0.00e+00	865.00
IUUC-Gac-042235	Gasterosteus aculeatus	77.19	0.00e+00	704.00
IUUC-Ggo-044767	Gorilla gorilla	92.67	0.00e+00	841.00
IUUC-Hsa-046581	Homo sapiens	98.16	0.00e+00	910.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	98.78	0.00e+00	880.00
IUUC-Lch-049732	Latimeria chalumnae	91.22	0.00e+00	857.00
IUUC-Loc-052371	Lepisosteus oculatus	89.39	0.00e+00	847.00
IUUC-Laf-054565	Loxodonta africana	98.57	0.00e+00	880.00
IUUC-Mcc-055522	Macaca mulatta	98.78	0.00e+00	916.00
IUUC-Meu-056754	Macropus eugenii	85.67	3.00e-158	551.00
IUUC-Mga-060095	Meleagris gallopavo	94.66	0.00e+00	638.00
IUUC-Mmr-060839	Microcebus murinus	98.57	0.00e+00	877.00
IUUC-Mdo-062339	Monodelphis domestica	97.47	0.00e+00	759.00
IUUC-Mmu-063638	Mus musculus	96.33	0.00e+00	842.00
IUUC-Mpu-066647	Mustela putorius furo	99.08	0.00e+00	768.00
IUUC-Mlu-067921	Myotis lucifugus	97.56	0.00e+00	900.00
IUUC-Nle-069752	Nomascus leucogenys	98.57	0.00e+00	915.00
IUUC-Opr-070636	Ochotona princeps	86.09	0.00e+00	724.00
IUUC-Ont-071638	Oreochromis niloticus	76.84	0.00e+00	701.00
IUUC-Oan-073417	Ornithorhynchus anatinus	90.20	0.00e+00	829.00
IUUC-Ocu-074620	Oryctolagus cuniculus	96.12	0.00e+00	860.00
IUUC-Ola-087281	Oryzias latipes	78.80	0.00e+00	630.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.33	1.00e-49	190.00
IUUC-Oga-088448	Otolemur garnettii	97.76	0.00e+00	906.00
IUUC-Oar-090132	Ovis aries	98.16	0.00e+00	879.00
IUUC-Ptr-090696	Pan troglodytes	98.37	0.00e+00	916.00
IUUC-Pan-092124	Papio anubis	98.37	0.00e+00	912.00
IUUC-Psi-093801	Pelodiscus sinensis	96.55	0.00e+00	753.00
IUUC-Pma-094472	Petromyzon marinus	72.69	8.00e-95	339.00
IUUC-Pfo-096330	Poecilia formosa	79.02	0.00e+00	736.00
IUUC-Pab-098191	Pongo abelii	98.78	0.00e+00	917.00
IUUC-Pca-100341	Procavia capensis	96.91	0.00e+00	666.00
IUUC-Pva-103177	Pteropus vampyrus	98.37	0.00e+00	867.00
IUUC-Rno-105048	Rattus norvegicus	94.92	0.00e+00	826.00
IUUC-Sha-107429	Sarcophilus harrisii	96.74	0.00e+00	870.00
IUUC-Sar-113024	Sorex araneus	96.80	0.00e+00	821.00
IUUC-Ssc-115749	Sus scrofa	96.80	4.00e-152	530.00
IUUC-Tgu-117277	Taeniopygia guttata	94.49	0.00e+00	886.00
IUUC-Tru-117844	Takifugu rubripes	79.23	0.00e+00	736.00
IUUC-Tsy-119456	Tarsius syrichta	95.71	0.00e+00	870.00
IUUC-Tni-120251	Tetraodon nigroviridis	75.00	0.00e+00	748.00
IUUC-Tbe-127423	Tupaia belangeri	91.63	0.00e+00	792.00
IUUC-Ttr-128401	Tursiops truncatus	91.82	0.00e+00	798.00
IUUC-Vpa-130549	Vicugna pacos	87.72	2.00e-163	568.00
IUUC-Xtr-131892	Xenopus tropicalis	83.37	0.00e+00	749.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence