iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044767

UUCD1 version

UUC-GoG-01092

Ensembl Protein ID

ENSGGOP00000027100.1

UniProt Accession

G3SG64; G3SG64_GORGO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000015288.2	ENSGGOT00000015343.2	ENSGGOP00000014917.2
ENSGGOG00000015288.2	ENSGGOT00000028533.1	ENSGGOP00000027100.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-96	324.1	129	480
UBD/ZnF/ZnF_UBP	1.10e-25	90.1	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkal 77
           tGl+NlgNtC+mN++LQ+L  ip+    ++e              k++l  ++  + +g+l+++++k + +lw+++++a+sp++l+ ++
   Q: 129  TGLRNLGNTCFMNAILQSLRDIPPPCLHFKEalhstvirsegtAVKHDLYSRDLCDCEGSLVEEFRKTLCALWQGSQTAFSPESLFYVV 217
           7*********************9977777774333555544443333333333377778****************************** PP
   S: 78   kkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssre 166
           +k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s ++
   Q: 218  WKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKF 305
           ******************************77444444444444444444.45688899999*************************** PP
   S: 167  epfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
           +pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r
   Q: 306  DPFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLR 392
           ***********77655555678899999****************************************************7755..799 PP
   S: 247  ekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvl 333
           +k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+l
   Q: 393  NKVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYIL 477
           *********************************************************.9*********************...****** PP
   S: 334  fYk 336
           fY 
   Q: 478  FYV 480
           **6 PP

UBD/ZnF/ZnF_UBP

   S: 5    vcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           vc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 1    VCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqdkaqhtvCMDCSSYSTYCYRCDDFVVN 74
           6***********************************************************************85 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH YEDAQVPLTN HKKSEKQDKA QHTVCMDCSS 60
YSTYCYRCDD FVVNDTKLGL VQKVREHLQN LENSAFTADR HRKRKLLENS TLNSKLLKVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTC CACACCTGAG CTCCAGCGTC TGCATTGCTC CGGACTCAGC CAAGTTCCCC 60
AACGGCTCCC CGTCGTCCTG GTGCTGCAGC GGTGAGTGCG GCCACGGGCC GGCCCCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	92.06	0.00e+00	819.00
IUUC-Apl-003358	Anas platyrhynchos	90.02	0.00e+00	829.00
IUUC-Aca-004454	Anolis carolinensis	87.16	0.00e+00	738.00
IUUC-Ame-011544	Astyanax mexicanus	73.36	0.00e+00	640.00
IUUC-Bta-012738	Bos taurus	91.65	0.00e+00	802.00
IUUC-Cel-018186	Caenorhabditis elegans	36.90	5.00e-52	198.00
IUUC-Cja-018893	Callithrix jacchus	93.28	0.00e+00	822.00
IUUC-Cfa-020607	Canis familiaris	92.67	0.00e+00	805.00
IUUC-Cpo-021828	Cavia porcellus	90.63	0.00e+00	789.00
IUUC-Csa-023884	Chlorocebus sabaeus	92.96	0.00e+00	713.00
IUUC-Cho-024863	Choloepus hoffmanni	82.08	0.00e+00	682.00
IUUC-Dre-028452	Danio rerio	69.90	0.00e+00	647.00
IUUC-Dno-029531	Dasypus novemcinctus	91.65	0.00e+00	803.00
IUUC-Dor-030913	Dipodomys ordii	81.79	9.00e-159	553.00
IUUC-Ete-032611	Echinops telfairi	85.74	0.00e+00	744.00
IUUC-Eca-033622	Equus caballus	92.67	0.00e+00	808.00
IUUC-Eeu-035268	Erinaceus europaeus	87.35	0.00e+00	746.00
IUUC-Fca-035801	Felis catus	92.06	0.00e+00	837.00
IUUC-Fal-036749	Ficedula albicollis	89.00	0.00e+00	781.00
IUUC-Gmo-039598	Gadus morhua	73.44	0.00e+00	667.00
IUUC-Gga-040883	Gallus gallus	90.22	0.00e+00	796.00
IUUC-Gac-042235	Gasterosteus aculeatus	72.36	0.00e+00	640.00
IUUC-Hsa-046581	Homo sapiens	93.69	0.00e+00	848.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	92.87	0.00e+00	809.00
IUUC-Lch-049732	Latimeria chalumnae	86.35	0.00e+00	790.00
IUUC-Loc-052371	Lepisosteus oculatus	84.73	0.00e+00	781.00
IUUC-Laf-054565	Loxodonta africana	92.46	0.00e+00	805.00
IUUC-Mcc-055522	Macaca mulatta	93.89	0.00e+00	850.00
IUUC-Meu-056754	Macropus eugenii	77.38	4.00e-137	481.00
IUUC-Mga-060095	Meleagris gallopavo	86.09	1.00e-163	568.00
IUUC-Mmr-060839	Microcebus murinus	92.67	0.00e+00	805.00
IUUC-Mdo-062339	Monodelphis domestica	91.06	0.00e+00	688.00
IUUC-Mmu-063638	Mus musculus	91.04	0.00e+00	776.00
IUUC-Mpu-066647	Mustela putorius furo	91.74	0.00e+00	690.00
IUUC-Mlu-067921	Myotis lucifugus	91.04	0.00e+00	821.00
IUUC-Nle-069752	Nomascus leucogenys	93.69	0.00e+00	848.00
IUUC-Opr-070636	Ochotona princeps	81.02	0.00e+00	667.00
IUUC-Ont-071638	Oreochromis niloticus	71.85	0.00e+00	636.00
IUUC-Oan-073417	Ornithorhynchus anatinus	84.52	0.00e+00	759.00
IUUC-Ocu-074620	Oryctolagus cuniculus	91.04	0.00e+00	798.00
IUUC-Ola-087281	Oryzias latipes	73.33	9.00e-163	566.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.59	9.00e-49	186.00
IUUC-Oga-088448	Otolemur garnettii	91.65	0.00e+00	831.00
IUUC-Oar-090132	Ovis aries	91.65	0.00e+00	803.00
IUUC-Ptr-090696	Pan troglodytes	94.09	0.00e+00	855.00
IUUC-Pan-092124	Papio anubis	93.48	0.00e+00	845.00
IUUC-Psi-093801	Pelodiscus sinensis	90.14	0.00e+00	682.00
IUUC-Pma-094300	Petromyzon marinus	70.79	9.00e-98	349.00
IUUC-Pfo-096330	Poecilia formosa	73.98	0.00e+00	668.00
IUUC-Pab-098191	Pongo abelii	93.89	0.00e+00	850.00
IUUC-Pca-100341	Procavia capensis	88.52	8.00e-171	593.00
IUUC-Pva-103177	Pteropus vampyrus	92.26	0.00e+00	793.00
IUUC-Rno-105048	Rattus norvegicus	89.66	0.00e+00	760.00
IUUC-Sha-107429	Sarcophilus harrisii	91.24	0.00e+00	799.00
IUUC-Sar-113024	Sorex araneus	90.64	0.00e+00	753.00
IUUC-Ssc-115749	Sus scrofa	86.17	1.00e-130	459.00
IUUC-Tgu-117277	Taeniopygia guttata	89.21	0.00e+00	818.00
IUUC-Tru-117844	Takifugu rubripes	74.39	0.00e+00	672.00
IUUC-Tsy-119456	Tarsius syrichta	90.00	0.00e+00	801.00
IUUC-Tni-120251	Tetraodon nigroviridis	70.39	0.00e+00	684.00
IUUC-Tbe-127423	Tupaia belangeri	86.56	0.00e+00	727.00
IUUC-Ttr-128401	Tursiops truncatus	90.00	0.00e+00	777.00
IUUC-Vpa-130549	Vicugna pacos	80.90	5.00e-146	510.00
IUUC-Xtr-131892	Xenopus tropicalis	78.20	0.00e+00	683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence