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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046581
UUCD1 version UUC-HoS-01172
Ensembl Protein ID ENSP00000369681.3
UniProt Accession Q9Y6I4; B4DVU5; F5H1A6; Q8WVD0; UBP3_HUMAN
Genbank Protein ID AAD42992.1; AAP35933.1; BAG62807.1; EAW77651.1; AAH18113.1; AAH65300.1; AAI07138.1; AAI07139.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3
Genbank Nucleotide ID AF073344; BT007269; AK301236; AC007950; BC018113; BC065300; BC107137; BC107138
Gene Name USP3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140455.16 ENST00000561442.5 ENSP00000453688.1
ENSG00000140455.16 ENST00000380324.7 ENSP00000369681.3
ENSG00000140455.16 ENST00000557884.5 ENSP00000454043.1
ENSG00000140455.16 ENST00000559873.5 ENSP00000453767.1
ENSG00000140455.16 ENST00000559192.5 ENSP00000453228.1
ENSG00000140455.16 ENST00000558285.5 ENSP00000453619.1
ENSG00000140455.16 ENST00000559257.5 ENSP00000452947.1
ENSG00000140455.16 ENST00000559711.5 ENSP00000453138.1
ENSG00000140455.16 ENST00000540797.5 ENSP00000445828.1
ENSG00000140455.16 ENST00000268049.11 ENSP00000268049.7
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexHINTMentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 17980597
UBD/ZnF/ZnF_UBP ZnF_UBP 24366338
Classification
Family E-value Score Start End
DUB/USP 5.70e-100 336.5 159 509
UBD/ZnF/ZnF_UBP 9.90e-27 94.6 27 104
Active Site
Position(s) Description Evidence
168 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
471 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkea 81
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++k+ 
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIM 250
           7******************************888888777765555555555688889********************************** PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++pfldls
   Q: 251  PNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLS 341
           **************************77444444444444444444.45688899999********************************** PP
   S: 174  lpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefp 256
           l++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+k++++vefp
   Q: 342  LDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRNKVDTYVEFP 431
           ****77655555678899999****************************************************7755..799********** PP
   S: 257  le.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           l+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lfY 
   Q: 432  LRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILFYV 509
           ***********************************************.9*********************...********6 PP
   

   UBD/ZnF/ZnF_UBP
   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqdkvqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
 Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Protein Sequence
(Fasta)
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQVPLTN HKKSEKQDKV QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046581|DUB,USP;UBD,ZnF_UBP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGGATCTC GGAGTTACAC GTTCTACGGA GCGGGGCGCC GGGAGACGGC GGGCGAGAAA 60
ACCCGGCGTC CGGAAGCCCG TGCTTTCTTT GACGCAAGGG CTCGAGACGC AGCCGCCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046581|DUB,USP;UBD,ZnF_UBP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:9960
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001537 Ailuropoda melanoleuca 97.88 0.00e+00 955.00
IUUC-Apl-003358 Anas platyrhynchos 95.71 0.00e+00 900.00
IUUC-Aca-004454 Anolis carolinensis 91.60 0.00e+00 826.00
IUUC-Ame-011544 Astyanax mexicanus 76.79 0.00e+00 739.00
IUUC-Bta-012738 Bos taurus 97.12 0.00e+00 934.00
IUUC-Cel-018186 Caenorhabditis elegans 37.08 2.00e-55 209.00
IUUC-Cja-018893 Callithrix jacchus 98.65 0.00e+00 953.00
IUUC-Cfa-020607 Canis familiaris 98.46 0.00e+00 942.00
IUUC-Cpo-021828 Cavia porcellus 95.77 0.00e+00 919.00
IUUC-Csa-023884 Chlorocebus sabaeus 99.53 0.00e+00 784.00
IUUC-Cho-024863 Choloepus hoffmanni 88.08 0.00e+00 813.00
IUUC-Dre-028452 Danio rerio 73.66 0.00e+00 752.00
IUUC-Dno-029531 Dasypus novemcinctus 97.55 0.00e+00 873.00
IUUC-Dor-030913 Dipodomys ordii 89.52 5.00e-178 617.00
IUUC-Ete-032611 Echinops telfairi 91.54 0.00e+00 878.00
IUUC-Eca-033622 Equus caballus 98.16 0.00e+00 877.00
IUUC-Eeu-035268 Erinaceus europaeus 92.23 0.00e+00 799.00
IUUC-Fca-035801 Felis catus 97.76 0.00e+00 906.00
IUUC-Fal-036749 Ficedula albicollis 94.70 0.00e+00 853.00
IUUC-Gmo-039598 Gadus morhua 76.91 0.00e+00 769.00
IUUC-Gga-040883 Gallus gallus 95.92 0.00e+00 867.00
IUUC-Gac-042235 Gasterosteus aculeatus 75.43 0.00e+00 739.00
IUUC-Ggo-044767 Gorilla gorilla 93.69 0.00e+00 848.00
IUUC-Itr-047898 Ictidomys tridecemlineatus 98.46 0.00e+00 944.00
IUUC-Lch-049732 Latimeria chalumnae 91.15 0.00e+00 916.00
IUUC-Loc-052371 Lepisosteus oculatus 89.23 0.00e+00 903.00
IUUC-Laf-054565 Loxodonta africana 97.88 0.00e+00 939.00
IUUC-Mcc-055522 Macaca mulatta 99.23 0.00e+00 983.00
IUUC-Meu-056754 Macropus eugenii 86.30 3.00e-177 614.00
IUUC-Mga-060095 Meleagris gallopavo 94.36 0.00e+00 639.00
IUUC-Mmr-060839 Microcebus murinus 98.65 0.00e+00 944.00
IUUC-Mdo-062339 Monodelphis domestica 97.24 0.00e+00 758.00
IUUC-Mmu-063638 Mus musculus 96.54 0.00e+00 908.00
IUUC-Mpu-066647 Mustela putorius furo 98.16 0.00e+00 761.00
IUUC-Mlu-067921 Myotis lucifugus 96.53 0.00e+00 889.00
IUUC-Nle-069752 Nomascus leucogenys 99.23 0.00e+00 982.00
IUUC-Opr-070636 Ochotona princeps 83.08 0.00e+00 735.00
IUUC-Ont-071638 Oreochromis niloticus 76.63 0.00e+00 698.00
IUUC-Oan-073417 Ornithorhynchus anatinus 90.38 0.00e+00 892.00
IUUC-Ocu-074620 Oryctolagus cuniculus 96.54 0.00e+00 931.00
IUUC-Ola-087281 Oryzias latipes 78.57 0.00e+00 627.00
IUUC-Olu-087697 Ostreococcus lucimarinus 40.59 1.00e-48 187.00
IUUC-Oga-088448 Otolemur garnettii 97.69 0.00e+00 969.00
IUUC-Oar-090132 Ovis aries 96.92 0.00e+00 934.00
IUUC-Ptr-090696 Pan troglodytes 99.39 0.00e+00 924.00
IUUC-Pan-092124 Papio anubis 98.85 0.00e+00 979.00
IUUC-Psi-093801 Pelodiscus sinensis 96.32 0.00e+00 751.00
IUUC-Pma-094472 Petromyzon marinus 71.93 1.00e-94 338.00
IUUC-Pfo-096330 Poecilia formosa 78.12 0.00e+00 780.00
IUUC-Pab-098191 Pongo abelii 99.42 0.00e+00 984.00
IUUC-Pca-100341 Procavia capensis 96.11 0.00e+00 726.00
IUUC-Pva-103177 Pteropus vampyrus 97.88 0.00e+00 929.00
IUUC-Rno-105048 Rattus norvegicus 95.21 0.00e+00 892.00
IUUC-Sha-107429 Sarcophilus harrisii 95.98 0.00e+00 871.00
IUUC-Sar-113024 Sorex araneus 95.74 0.00e+00 816.00
IUUC-Ssc-115749 Sus scrofa 96.09 1.00e-151 529.00
IUUC-Tgu-117277 Taeniopygia guttata 94.90 0.00e+00 888.00
IUUC-Tru-117844 Takifugu rubripes 78.31 0.00e+00 776.00
IUUC-Tsy-119456 Tarsius syrichta 95.30 0.00e+00 868.00
IUUC-Tni-120251 Tetraodon nigroviridis 74.33 0.00e+00 788.00
IUUC-Tbe-127423 Tupaia belangeri 91.92 0.00e+00 856.00
IUUC-Ttr-128401 Tursiops truncatus 90.59 0.00e+00 789.00
IUUC-Vpa-130549 Vicugna pacos 87.43 6.00e-164 570.00
IUUC-Xtr-131892 Xenopus tropicalis 82.80 0.00e+00 799.00
Created Date 25-Jun-2017

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