iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054565

UUCD1 version

UUC-LoA-01081

Ensembl Protein ID

ENSLAFP00000003395.3

UniProt Accession

G3STK4; G3STK4_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000004065.3	ENSLAFT00000004065.3	ENSLAFP00000003395.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-100	335.7	159	510
UBD/ZnF/ZnF_UBP	3.40e-27	94.8	27	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++ +a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSPTAFSPESLFYVVW 247
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGVLQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRNKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+a++ + +g+W++f+Ds+Vt ++ee+vl+   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSGPENCLYDLAAVVVHHGsGVGSGHYTAFATH-EGRWFHFNDSTVTLTDEETVLK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqdkaqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MECPHLGSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQVPLTN HKKSEKQDKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTC CGCACCTCGG CTCCAGCGTC TGCATCGCTC CGGACTCCGC CAAGTTCCCC 60
AACGGCTCCC CGTCGTCCTG GTGCTGCAGC GGTGAGTGCG GTCCGGGCCG GCGCGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100668665

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	97.69	0.00e+00	953.00
IUUC-Apl-003358	Anas platyrhynchos	95.31	0.00e+00	897.00
IUUC-Aca-004454	Anolis carolinensis	91.99	0.00e+00	823.00
IUUC-Ame-011544	Astyanax mexicanus	76.98	0.00e+00	737.00
IUUC-Bta-012738	Bos taurus	97.70	0.00e+00	936.00
IUUC-Cel-018186	Caenorhabditis elegans	37.99	4.00e-56	212.00
IUUC-Cja-018893	Callithrix jacchus	97.69	0.00e+00	947.00
IUUC-Cfa-020607	Canis familiaris	98.27	0.00e+00	940.00
IUUC-Cpo-021828	Cavia porcellus	95.58	0.00e+00	913.00
IUUC-Csa-023884	Chlorocebus sabaeus	98.35	0.00e+00	776.00
IUUC-Cho-024863	Choloepus hoffmanni	87.88	0.00e+00	812.00
IUUC-Dre-028452	Danio rerio	73.85	0.00e+00	748.00
IUUC-Dno-029531	Dasypus novemcinctus	97.14	0.00e+00	872.00
IUUC-Dor-030913	Dipodomys ordii	88.92	8.00e-177	613.00
IUUC-Ete-032611	Echinops telfairi	91.92	0.00e+00	880.00
IUUC-Eca-033622	Equus caballus	98.57	0.00e+00	879.00
IUUC-Eeu-035268	Erinaceus europaeus	92.23	0.00e+00	798.00
IUUC-Fca-035801	Felis catus	97.55	0.00e+00	904.00
IUUC-Fal-036749	Ficedula albicollis	94.50	0.00e+00	850.00
IUUC-Gmo-039598	Gadus morhua	76.13	0.00e+00	763.00
IUUC-Gga-040883	Gallus gallus	95.51	0.00e+00	862.00
IUUC-Gac-042235	Gasterosteus aculeatus	75.43	0.00e+00	740.00
IUUC-Ggo-044767	Gorilla gorilla	92.46	0.00e+00	838.00
IUUC-Hsa-046581	Homo sapiens	97.88	0.00e+00	972.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	98.27	0.00e+00	941.00
IUUC-Lch-049732	Latimeria chalumnae	91.15	0.00e+00	915.00
IUUC-Loc-052371	Lepisosteus oculatus	89.42	0.00e+00	903.00
IUUC-Mcc-055522	Macaca mulatta	98.27	0.00e+00	976.00
IUUC-Meu-056754	Macropus eugenii	86.30	1.00e-177	615.00
IUUC-Mga-060095	Meleagris gallopavo	94.36	0.00e+00	637.00
IUUC-Mmr-060839	Microcebus murinus	98.08	0.00e+00	939.00
IUUC-Mdo-062339	Monodelphis domestica	97.01	0.00e+00	756.00
IUUC-Mmu-063638	Mus musculus	96.15	0.00e+00	903.00
IUUC-Mpu-066647	Mustela putorius furo	98.16	0.00e+00	761.00
IUUC-Mlu-067921	Myotis lucifugus	96.94	0.00e+00	891.00
IUUC-Nle-069752	Nomascus leucogenys	98.27	0.00e+00	976.00
IUUC-Opr-070636	Ochotona princeps	82.50	0.00e+00	727.00
IUUC-Ont-071638	Oreochromis niloticus	76.21	0.00e+00	696.00
IUUC-Oan-073417	Ornithorhynchus anatinus	90.19	0.00e+00	891.00
IUUC-Ocu-074620	Oryctolagus cuniculus	95.96	0.00e+00	922.00
IUUC-Ola-087281	Oryzias latipes	78.34	3.00e-180	624.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.66	6.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	97.12	0.00e+00	966.00
IUUC-Oar-090132	Ovis aries	97.12	0.00e+00	935.00
IUUC-Ptr-090696	Pan troglodytes	98.17	0.00e+00	912.00
IUUC-Pan-092124	Papio anubis	97.88	0.00e+00	972.00
IUUC-Psi-093801	Pelodiscus sinensis	96.09	0.00e+00	749.00
IUUC-Pma-094472	Petromyzon marinus	72.81	1.00e-95	342.00
IUUC-Pfo-096330	Poecilia formosa	77.54	0.00e+00	775.00
IUUC-Pab-098191	Pongo abelii	98.46	0.00e+00	978.00
IUUC-Pca-100341	Procavia capensis	97.41	0.00e+00	732.00
IUUC-Pva-103177	Pteropus vampyrus	97.88	0.00e+00	926.00
IUUC-Rno-105048	Rattus norvegicus	94.83	0.00e+00	887.00
IUUC-Sha-107429	Sarcophilus harrisii	95.57	0.00e+00	867.00
IUUC-Sar-113024	Sorex araneus	95.74	0.00e+00	814.00
IUUC-Ssc-115749	Sus scrofa	96.44	1.00e-151	528.00
IUUC-Tgu-117277	Taeniopygia guttata	94.29	0.00e+00	883.00
IUUC-Tru-117844	Takifugu rubripes	78.12	0.00e+00	775.00
IUUC-Tsy-119456	Tarsius syrichta	95.71	0.00e+00	868.00
IUUC-Tni-120251	Tetraodon nigroviridis	73.95	0.00e+00	787.00
IUUC-Tbe-127423	Tupaia belangeri	91.35	0.00e+00	850.00
IUUC-Ttr-128401	Tursiops truncatus	91.00	0.00e+00	793.00
IUUC-Vpa-130549	Vicugna pacos	87.43	4.00e-163	566.00
IUUC-Xtr-131892	Xenopus tropicalis	83.18	0.00e+00	797.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence