iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069752

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADFV01035575

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000012274.2	ENSNLET00000015676.2	ENSNLEP00000014930.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-100	336.2	159	510
UBD/ZnF/ZnF_UBP	7.00e-29	99.9	27	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqekaqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQVPLTN HKKSEKQEKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTGAAAGT CCTACGACGT GCTGGAGGTA ACGCAGATGG TGAGTCACAG TGACAGGGTT 60
TGAACGCGGG TTCGTGGGCG CCCCTACGGG CCCAGCCACG CAGCATCTAG GTGGCTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100596423

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	98.08	0.00e+00	957.00
IUUC-Apl-003358	Anas platyrhynchos	96.12	0.00e+00	904.00
IUUC-Aca-004454	Anolis carolinensis	91.80	0.00e+00	827.00
IUUC-Ame-011544	Astyanax mexicanus	76.98	0.00e+00	742.00
IUUC-Bta-012738	Bos taurus	97.89	0.00e+00	939.00
IUUC-Cel-018186	Caenorhabditis elegans	37.08	2.00e-55	209.00
IUUC-Cja-018893	Callithrix jacchus	99.04	0.00e+00	957.00
IUUC-Cfa-020607	Canis familiaris	98.65	0.00e+00	944.00
IUUC-Cpo-021828	Cavia porcellus	95.96	0.00e+00	920.00
IUUC-Csa-023884	Chlorocebus sabaeus	100.00	0.00e+00	788.00
IUUC-Cho-024863	Choloepus hoffmanni	88.08	0.00e+00	815.00
IUUC-Dre-028452	Danio rerio	74.05	0.00e+00	751.00
IUUC-Dno-029531	Dasypus novemcinctus	97.55	0.00e+00	876.00
IUUC-Dor-030913	Dipodomys ordii	90.12	7.00e-179	619.00
IUUC-Ete-032611	Echinops telfairi	91.92	0.00e+00	881.00
IUUC-Eca-033622	Equus caballus	98.57	0.00e+00	881.00
IUUC-Eeu-035268	Erinaceus europaeus	92.64	0.00e+00	802.00
IUUC-Fca-035801	Felis catus	97.96	0.00e+00	909.00
IUUC-Fal-036749	Ficedula albicollis	95.11	0.00e+00	856.00
IUUC-Gmo-039598	Gadus morhua	77.10	0.00e+00	771.00
IUUC-Gga-040883	Gallus gallus	96.33	0.00e+00	870.00
IUUC-Gac-042235	Gasterosteus aculeatus	76.01	0.00e+00	742.00
IUUC-Ggo-044767	Gorilla gorilla	93.69	0.00e+00	847.00
IUUC-Hsa-046581	Homo sapiens	99.23	0.00e+00	982.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	98.85	0.00e+00	948.00
IUUC-Lch-049732	Latimeria chalumnae	91.54	0.00e+00	920.00
IUUC-Loc-052371	Lepisosteus oculatus	89.62	0.00e+00	907.00
IUUC-Laf-054565	Loxodonta africana	98.27	0.00e+00	942.00
IUUC-Mcc-055522	Macaca mulatta	99.62	0.00e+00	987.00
IUUC-Meu-056754	Macropus eugenii	86.58	1.00e-177	616.00
IUUC-Mga-060095	Meleagris gallopavo	94.66	0.00e+00	640.00
IUUC-Mmr-060839	Microcebus murinus	98.65	0.00e+00	945.00
IUUC-Mdo-062339	Monodelphis domestica	97.70	0.00e+00	761.00
IUUC-Mmu-063638	Mus musculus	97.31	0.00e+00	915.00
IUUC-Mpu-066647	Mustela putorius furo	98.62	0.00e+00	765.00
IUUC-Mlu-067921	Myotis lucifugus	96.94	0.00e+00	893.00
IUUC-Opr-070636	Ochotona princeps	83.08	0.00e+00	734.00
IUUC-Ont-071638	Oreochromis niloticus	77.26	0.00e+00	702.00
IUUC-Oan-073417	Ornithorhynchus anatinus	90.77	0.00e+00	895.00
IUUC-Ocu-074620	Oryctolagus cuniculus	96.73	0.00e+00	929.00
IUUC-Ola-087281	Oryzias latipes	79.03	0.00e+00	630.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.33	5.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	97.69	0.00e+00	970.00
IUUC-Oar-090132	Ovis aries	97.69	0.00e+00	941.00
IUUC-Ptr-090696	Pan troglodytes	99.39	0.00e+00	922.00
IUUC-Pan-092124	Papio anubis	99.23	0.00e+00	982.00
IUUC-Psi-093801	Pelodiscus sinensis	96.78	0.00e+00	754.00
IUUC-Pma-094472	Petromyzon marinus	72.37	9.00e-95	339.00
IUUC-Pfo-096330	Poecilia formosa	78.50	0.00e+00	783.00
IUUC-Pab-098191	Pongo abelii	99.81	0.00e+00	988.00
IUUC-Pca-100341	Procavia capensis	96.37	0.00e+00	728.00
IUUC-Pva-103177	Pteropus vampyrus	98.27	0.00e+00	932.00
IUUC-Rno-105048	Rattus norvegicus	95.98	0.00e+00	899.00
IUUC-Sha-107429	Sarcophilus harrisii	96.38	0.00e+00	874.00
IUUC-Sar-113024	Sorex araneus	96.16	0.00e+00	820.00
IUUC-Ssc-115749	Sus scrofa	96.44	5.00e-152	530.00
IUUC-Tgu-117277	Taeniopygia guttata	95.31	0.00e+00	892.00
IUUC-Tru-117844	Takifugu rubripes	78.69	0.00e+00	780.00
IUUC-Tsy-119456	Tarsius syrichta	95.71	0.00e+00	871.00
IUUC-Tni-120251	Tetraodon nigroviridis	74.90	0.00e+00	793.00
IUUC-Tbe-127423	Tupaia belangeri	92.69	0.00e+00	863.00
IUUC-Ttr-128401	Tursiops truncatus	91.41	0.00e+00	796.00
IUUC-Vpa-130549	Vicugna pacos	88.32	3.00e-165	573.00
IUUC-Xtr-131892	Xenopus tropicalis	82.99	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence