iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073417

UUCD1 version

UUC-OrA-00838

Ensembl Protein ID

ENSOANP00000017660.2

UniProt Accession

F7D679; F7D679_ORNAN

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000011148.2	ENSOANT00000017663.2	ENSOANP00000017660.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-100	335.9	159	510

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    +   +++s ls + ++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSVILQENSGLSAS-NKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************7755555555555555555554.688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRNKRSknqengpmcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MECPHLGSSV CIAPDSAKFP HGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLNN HKKTEKQEKV QHTVCMDCSS YSTYCLDCQF FKTNINKIFQ VLTIRSQLEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGCCCTT CTTTTTTAAC GCGATGGGCG CGGGGGCGGC GCGCCGGCCG CTGGAGCGCT 60
GAGCGAGCGG GAGCGGGAGC GGGAGTCGCC CGCAGCAGCA GCAGCAGCAG CAGCAGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	89.81	0.00e+00	877.00
IUUC-Apl-003358	Anas platyrhynchos	91.22	0.00e+00	840.00
IUUC-Aca-004454	Anolis carolinensis	87.30	0.00e+00	771.00
IUUC-Ame-011544	Astyanax mexicanus	72.92	0.00e+00	689.00
IUUC-Bta-012738	Bos taurus	90.21	0.00e+00	860.00
IUUC-Cel-018186	Caenorhabditis elegans	37.29	6.00e-56	211.00
IUUC-Cja-018893	Callithrix jacchus	89.81	0.00e+00	863.00
IUUC-Cfa-020607	Canis familiaris	90.38	0.00e+00	864.00
IUUC-Cpo-021828	Cavia porcellus	88.46	0.00e+00	844.00
IUUC-Csa-023884	Chlorocebus sabaeus	90.54	0.00e+00	701.00
IUUC-Cho-024863	Choloepus hoffmanni	80.38	0.00e+00	740.00
IUUC-Dre-028452	Danio rerio	69.66	0.00e+00	696.00
IUUC-Dno-029531	Dasypus novemcinctus	89.80	0.00e+00	801.00
IUUC-Dor-030913	Dipodomys ordii	81.74	2.00e-160	558.00
IUUC-Ete-032611	Echinops telfairi	84.62	0.00e+00	808.00
IUUC-Eca-033622	Equus caballus	90.20	0.00e+00	803.00
IUUC-Eeu-035268	Erinaceus europaeus	85.07	0.00e+00	729.00
IUUC-Fca-035801	Felis catus	90.00	0.00e+00	828.00
IUUC-Fal-036749	Ficedula albicollis	90.02	0.00e+00	800.00
IUUC-Gmo-039598	Gadus morhua	72.41	0.00e+00	719.00
IUUC-Gga-040883	Gallus gallus	91.43	0.00e+00	814.00
IUUC-Gac-042235	Gasterosteus aculeatus	71.59	0.00e+00	686.00
IUUC-Ggo-044767	Gorilla gorilla	84.52	0.00e+00	759.00
IUUC-Hsa-046581	Homo sapiens	90.38	0.00e+00	893.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	90.38	0.00e+00	864.00
IUUC-Lch-049732	Latimeria chalumnae	85.77	0.00e+00	852.00
IUUC-Loc-052371	Lepisosteus oculatus	84.62	0.00e+00	840.00
IUUC-Laf-054565	Loxodonta africana	90.19	0.00e+00	864.00
IUUC-Mcc-055522	Macaca mulatta	90.38	0.00e+00	894.00
IUUC-Meu-056754	Macropus eugenii	81.69	3.00e-168	584.00
IUUC-Mga-060095	Meleagris gallopavo	87.24	5.00e-168	582.00
IUUC-Mmr-060839	Microcebus murinus	90.58	0.00e+00	865.00
IUUC-Mdo-062339	Monodelphis domestica	91.26	0.00e+00	701.00
IUUC-Mmu-063638	Mus musculus	89.04	0.00e+00	831.00
IUUC-Mpu-066647	Mustela putorius furo	90.11	0.00e+00	694.00
IUUC-Mlu-067921	Myotis lucifugus	88.57	0.00e+00	815.00
IUUC-Nle-069752	Nomascus leucogenys	90.77	0.00e+00	896.00
IUUC-Opr-070636	Ochotona princeps	75.96	0.00e+00	661.00
IUUC-Ont-071638	Oreochromis niloticus	72.84	0.00e+00	649.00
IUUC-Ocu-074620	Oryctolagus cuniculus	88.65	0.00e+00	850.00
IUUC-Ola-087281	Oryzias latipes	74.42	1.00e-166	578.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.72	6.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	90.00	0.00e+00	885.00
IUUC-Oar-090132	Ovis aries	90.19	0.00e+00	863.00
IUUC-Ptr-090696	Pan troglodytes	90.02	0.00e+00	832.00
IUUC-Pan-092124	Papio anubis	90.00	0.00e+00	888.00
IUUC-Psi-093801	Pelodiscus sinensis	90.80	0.00e+00	699.00
IUUC-Pma-094300	Petromyzon marinus	70.79	8.00e-99	352.00
IUUC-Pfo-096330	Poecilia formosa	73.13	0.00e+00	718.00
IUUC-Pab-098191	Pongo abelii	90.58	0.00e+00	895.00
IUUC-Pca-100341	Procavia capensis	86.27	0.00e+00	650.00
IUUC-Pva-103177	Pteropus vampyrus	89.81	0.00e+00	851.00
IUUC-Rno-105048	Rattus norvegicus	87.74	0.00e+00	816.00
IUUC-Sha-107429	Sarcophilus harrisii	91.15	0.00e+00	816.00
IUUC-Sar-113024	Sorex araneus	88.06	0.00e+00	743.00
IUUC-Ssc-115749	Sus scrofa	83.63	3.00e-130	456.00
IUUC-Tgu-117277	Taeniopygia guttata	89.80	0.00e+00	825.00
IUUC-Tru-117844	Takifugu rubripes	73.51	0.00e+00	715.00
IUUC-Tsy-119456	Tarsius syrichta	87.32	0.00e+00	791.00
IUUC-Tni-120251	Tetraodon nigroviridis	70.31	0.00e+00	735.00
IUUC-Tbe-127423	Tupaia belangeri	83.85	0.00e+00	781.00
IUUC-Ttr-128401	Tursiops truncatus	83.84	0.00e+00	722.00
IUUC-Vpa-130549	Vicugna pacos	77.84	2.00e-143	501.00
IUUC-Xtr-131892	Xenopus tropicalis	77.88	0.00e+00	739.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence