iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074620

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAGW02025072

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000014775.3	ENSOCUT00000014775.3	ENSOCUP00000012707.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-100	336.0	159	509
UBD/ZnF/ZnF_UBP	4.70e-27	94.1	27	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDTSVSLVEEFRKTLCALWQGSQTAFSPESLFYVIW 247
           7******************************888888777775555555556688999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  ++ +++ + +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAVLQE-NSTLSASSKCCVNGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************664444444444444.3444445788889999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe+++ e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v +   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSDPENCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVGK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Yk 336
           Y 
   Q: 508  YV 509
           *6 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLtnhkksekqekiqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLTN HKKSEKQEKI QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTC CGCACCTCAG CTCCAGCGTC TGCATCGCTC CGGACTCAGC CAAGTTTCCC 60
AACGGGTCCC CGTCGTCCTG GTGCTGCAGC GGTGAGTGCG GCCCCGGCCC GGCCCGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100345783

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	96.35	0.00e+00	942.00
IUUC-Apl-003358	Anas platyrhynchos	94.08	0.00e+00	887.00
IUUC-Aca-004454	Anolis carolinensis	91.60	0.00e+00	825.00
IUUC-Ame-011544	Astyanax mexicanus	77.37	0.00e+00	741.00
IUUC-Bta-012738	Bos taurus	95.97	0.00e+00	919.00
IUUC-Cel-018186	Caenorhabditis elegans	37.05	4.00e-55	209.00
IUUC-Cja-018893	Callithrix jacchus	95.96	0.00e+00	935.00
IUUC-Cfa-020607	Canis familiaris	96.54	0.00e+00	925.00
IUUC-Cpo-021828	Cavia porcellus	94.81	0.00e+00	910.00
IUUC-Csa-023884	Chlorocebus sabaeus	96.47	0.00e+00	764.00
IUUC-Cho-024863	Choloepus hoffmanni	85.96	0.00e+00	796.00
IUUC-Dre-028452	Danio rerio	75.05	0.00e+00	757.00
IUUC-Dno-029531	Dasypus novemcinctus	94.90	0.00e+00	852.00
IUUC-Dor-030913	Dipodomys ordii	88.02	2.00e-175	608.00
IUUC-Ete-032611	Echinops telfairi	89.62	0.00e+00	864.00
IUUC-Eca-033622	Equus caballus	96.12	0.00e+00	859.00
IUUC-Eeu-035268	Erinaceus europaeus	91.62	0.00e+00	790.00
IUUC-Fca-035801	Felis catus	95.10	0.00e+00	886.00
IUUC-Fal-036749	Ficedula albicollis	93.48	0.00e+00	845.00
IUUC-Gmo-039598	Gadus morhua	77.10	0.00e+00	773.00
IUUC-Gga-040883	Gallus gallus	94.29	0.00e+00	852.00
IUUC-Gac-042235	Gasterosteus aculeatus	76.39	0.00e+00	746.00
IUUC-Ggo-044767	Gorilla gorilla	91.04	0.00e+00	831.00
IUUC-Hsa-046581	Homo sapiens	96.54	0.00e+00	965.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	96.73	0.00e+00	927.00
IUUC-Lch-049732	Latimeria chalumnae	89.23	0.00e+00	903.00
IUUC-Loc-052371	Lepisosteus oculatus	88.65	0.00e+00	896.00
IUUC-Laf-054565	Loxodonta africana	95.96	0.00e+00	922.00
IUUC-Mcc-055522	Macaca mulatta	96.35	0.00e+00	961.00
IUUC-Meu-056754	Macropus eugenii	84.66	2.00e-175	608.00
IUUC-Mga-060095	Meleagris gallopavo	93.47	0.00e+00	635.00
IUUC-Mmr-060839	Microcebus murinus	96.73	0.00e+00	927.00
IUUC-Mdo-062339	Monodelphis domestica	95.63	0.00e+00	744.00
IUUC-Mmu-063638	Mus musculus	96.15	0.00e+00	904.00
IUUC-Mpu-066647	Mustela putorius furo	96.32	0.00e+00	747.00
IUUC-Mlu-067921	Myotis lucifugus	94.69	0.00e+00	873.00
IUUC-Nle-069752	Nomascus leucogenys	96.73	0.00e+00	963.00
IUUC-Opr-070636	Ochotona princeps	83.65	0.00e+00	744.00
IUUC-Ont-071638	Oreochromis niloticus	76.63	0.00e+00	696.00
IUUC-Oan-073417	Ornithorhynchus anatinus	88.65	0.00e+00	877.00
IUUC-Ola-087281	Oryzias latipes	78.57	2.00e-180	624.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.16	5.00e-48	184.00
IUUC-Oga-088448	Otolemur garnettii	96.15	0.00e+00	957.00
IUUC-Oar-090132	Ovis aries	95.77	0.00e+00	923.00
IUUC-Ptr-090696	Pan troglodytes	96.33	0.00e+00	901.00
IUUC-Pan-092124	Papio anubis	95.96	0.00e+00	956.00
IUUC-Psi-093801	Pelodiscus sinensis	93.79	0.00e+00	732.00
IUUC-Pma-094472	Petromyzon marinus	71.49	3.00e-94	337.00
IUUC-Pfo-096330	Poecilia formosa	79.34	0.00e+00	779.00
IUUC-Pab-098191	Pongo abelii	96.54	0.00e+00	962.00
IUUC-Pca-100341	Procavia capensis	94.30	0.00e+00	714.00
IUUC-Pva-103177	Pteropus vampyrus	95.58	0.00e+00	909.00
IUUC-Rno-105048	Rattus norvegicus	94.83	0.00e+00	889.00
IUUC-Sha-107429	Sarcophilus harrisii	94.77	0.00e+00	858.00
IUUC-Sar-113024	Sorex araneus	94.88	0.00e+00	802.00
IUUC-Ssc-115749	Sus scrofa	93.95	5.00e-149	520.00
IUUC-Tgu-117277	Taeniopygia guttata	93.67	0.00e+00	882.00
IUUC-Tru-117844	Takifugu rubripes	78.50	0.00e+00	775.00
IUUC-Tsy-119456	Tarsius syrichta	94.07	0.00e+00	856.00
IUUC-Tni-120251	Tetraodon nigroviridis	74.90	0.00e+00	792.00
IUUC-Tbe-127423	Tupaia belangeri	90.96	0.00e+00	845.00
IUUC-Ttr-128401	Tursiops truncatus	89.16	0.00e+00	776.00
IUUC-Vpa-130549	Vicugna pacos	86.23	2.00e-161	561.00
IUUC-Xtr-131892	Xenopus tropicalis	81.85	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence