iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000017714.7	ENSRNOT00000057739.4	ENSRNOP00000054551.4
ENSRNOG00000017714.7	ENSRNOT00000080319.1	ENSRNOP00000073732.1

Annotation

mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-99	333.9	161	512
UBD/ZnF/ZnF_UBP	8.10e-26	90.4	27	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 161  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 249
           7******************************888888777775555555556688999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+l + +++   +  +++++++F+g l++++ cl c+++s +++
   Q: 250  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTL-SANNKCCINGASTVVTTIFGGILQNEVNCLICGTESRKFD 337
           *****************************7644444444444443334.446788999999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+ L+lhLkRf+++   + r+
   Q: 338  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTA--YLRN 424
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++v+fpl+ Ld++ ++ +pe++  +++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt+++ee+v +   ++aY+lf
   Q: 425  KVDTYVQFPLRgLDMKCYLLEPENSGPDSCLYDLAAVVVHHGsGVGSGHYTAYAVH-EGRWFHFNDSTVTVTDEETVGK---AKAYILF 509
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 510  YVE 512
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl..................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye  + pl                  ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEMHEIPLlnhpxkrsekqekaqhtvCMDCSSYSTYCYRCDDFVVN 106
           9*****************************************************************************85 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEMHEIPLLN HPXKRSEKQE KAQHTVCMDC SSYSTYCYRC DDFVVNDTKL GLVQKVREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCCACCT TCTGCCCAGC GCCGGGTCAG AAGCGACCCC AGACGGAGCC TCCGAAGTCC 60
CTCCGCCCCA GAGCCTCGGC CGTCCCCGCC GCCGTCCTCG TGGCCATGGA GTGTCCGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	95.40	0.00e+00	930.00
IUUC-Apl-003358	Anas platyrhynchos	92.89	0.00e+00	872.00
IUUC-Aca-004454	Anolis carolinensis	89.69	0.00e+00	801.00
IUUC-Ame-011544	Astyanax mexicanus	75.83	0.00e+00	724.00
IUUC-Bta-012738	Bos taurus	94.84	0.00e+00	907.00
IUUC-Cel-018186	Caenorhabditis elegans	36.49	3.00e-54	206.00
IUUC-Cja-018893	Callithrix jacchus	95.98	0.00e+00	929.00
IUUC-Cfa-020607	Canis familiaris	95.40	0.00e+00	912.00
IUUC-Cpo-021828	Cavia porcellus	93.87	0.00e+00	899.00
IUUC-Csa-023884	Chlorocebus sabaeus	96.94	0.00e+00	767.00
IUUC-Cho-024863	Choloepus hoffmanni	85.82	0.00e+00	798.00
IUUC-Dre-028452	Danio rerio	73.66	0.00e+00	743.00
IUUC-Dno-029531	Dasypus novemcinctus	94.51	0.00e+00	847.00
IUUC-Dor-030913	Dipodomys ordii	87.20	4.00e-172	597.00
IUUC-Ete-032611	Echinops telfairi	89.27	0.00e+00	856.00
IUUC-Eca-033622	Equus caballus	94.92	0.00e+00	845.00
IUUC-Eeu-035268	Erinaceus europaeus	89.82	0.00e+00	772.00
IUUC-Fca-035801	Felis catus	94.31	0.00e+00	875.00
IUUC-Fal-036749	Ficedula albicollis	92.70	0.00e+00	832.00
IUUC-Gmo-039598	Gadus morhua	76.22	0.00e+00	761.00
IUUC-Gga-040883	Gallus gallus	93.09	0.00e+00	837.00
IUUC-Gac-042235	Gasterosteus aculeatus	74.90	0.00e+00	733.00
IUUC-Ggo-044767	Gorilla gorilla	89.66	0.00e+00	813.00
IUUC-Hsa-046581	Homo sapiens	95.21	0.00e+00	946.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	95.59	0.00e+00	914.00
IUUC-Lch-049732	Latimeria chalumnae	88.46	0.00e+00	893.00
IUUC-Loc-052371	Lepisosteus oculatus	87.12	0.00e+00	884.00
IUUC-Laf-054565	Loxodonta africana	94.83	0.00e+00	908.00
IUUC-Mcc-055522	Macaca mulatta	95.59	0.00e+00	951.00
IUUC-Meu-056754	Macropus eugenii	83.65	4.00e-171	594.00
IUUC-Mga-060095	Meleagris gallopavo	92.04	1.00e-178	619.00
IUUC-Mmr-060839	Microcebus murinus	95.40	0.00e+00	911.00
IUUC-Mdo-062339	Monodelphis domestica	95.63	0.00e+00	744.00
IUUC-Mmu-063638	Mus musculus	98.28	0.00e+00	914.00
IUUC-Mpu-066647	Mustela putorius furo	96.55	0.00e+00	749.00
IUUC-Mlu-067921	Myotis lucifugus	93.50	0.00e+00	860.00
IUUC-Nle-069752	Nomascus leucogenys	95.98	0.00e+00	953.00
IUUC-Opr-070636	Ochotona princeps	81.42	0.00e+00	716.00
IUUC-Ont-071638	Oreochromis niloticus	75.37	0.00e+00	692.00
IUUC-Oan-073417	Ornithorhynchus anatinus	87.74	0.00e+00	863.00
IUUC-Ocu-074620	Oryctolagus cuniculus	94.83	0.00e+00	910.00
IUUC-Ola-087281	Oryzias latipes	77.88	2.00e-179	622.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.67	1.00e-47	183.00
IUUC-Oga-088448	Otolemur garnettii	94.83	0.00e+00	941.00
IUUC-Oar-090132	Ovis aries	94.83	0.00e+00	910.00
IUUC-Ptr-090696	Pan troglodytes	95.13	0.00e+00	885.00
IUUC-Pan-092124	Papio anubis	95.21	0.00e+00	946.00
IUUC-Psi-093801	Pelodiscus sinensis	94.25	0.00e+00	736.00
IUUC-Pma-094472	Petromyzon marinus	71.74	7.00e-93	332.00
IUUC-Pfo-096330	Poecilia formosa	76.58	0.00e+00	770.00
IUUC-Pab-098191	Pongo abelii	95.79	0.00e+00	952.00
IUUC-Pca-100341	Procavia capensis	94.33	0.00e+00	708.00
IUUC-Pva-103177	Pteropus vampyrus	94.83	0.00e+00	899.00
IUUC-Sha-107429	Sarcophilus harrisii	93.39	0.00e+00	842.00
IUUC-Sar-113024	Sorex araneus	93.63	0.00e+00	793.00
IUUC-Ssc-115749	Sus scrofa	95.37	6.00e-150	523.00
IUUC-Tgu-117277	Taeniopygia guttata	92.89	0.00e+00	870.00
IUUC-Tru-117844	Takifugu rubripes	77.63	0.00e+00	766.00
IUUC-Tsy-119456	Tarsius syrichta	93.48	0.00e+00	847.00
IUUC-Tni-120251	Tetraodon nigroviridis	73.56	0.00e+00	781.00
IUUC-Tbe-127423	Tupaia belangeri	90.23	0.00e+00	836.00
IUUC-Ttr-128401	Tursiops truncatus	87.98	0.00e+00	763.00
IUUC-Vpa-130549	Vicugna pacos	86.31	9.00e-160	555.00
IUUC-Xtr-131892	Xenopus tropicalis	80.91	0.00e+00	781.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence