iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117844

UUCD1 version

UUC-TaR-01130

Ensembl Protein ID

ENSTRUP00000033156.1

UniProt Accession

H2U890; H2U890_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000013067.1	ENSTRUT00000033281.1	ENSTRUP00000033155.1
ENSTRUG00000013067.1	ENSTRUT00000033282.1	ENSTRUP00000033156.1
ENSTRUG00000013067.1	ENSTRUT00000033283.1	ENSTRUP00000033157.1
ENSTRUG00000013067.1	ENSTRUT00000033284.1	ENSTRUP00000033158.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-100	337.8	160	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             ++  + +++ +++ +l+++++k + +lw+++++a+sp +l+ +++
   Q: 160  TGLRNLGNTCFMNAILQSLSNIEQFSCYFKElpavslrsgktAGRRMYHTRSQGDSSVSLVEEFRKTLCSLWQGSQTAFSPDSLFYTIW 248
           7******************************888888777664444444555588899******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l++el+  +n   + ++ +d  +ls    +   + + s+++ +F+g l++++ cl c+++s +++
   Q: 249  KIMPSFRGYQQQDAHEFMRYLLDHLHRELQYGRNGASHAASPQDGVRLSAADGKCCINGTASVVTSIFGGILQNEVNCLICGTESRKFD 337
           *****************************9999999999999999999999************************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y+c kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 338  PFLDLSLDIPSQFRQKRSkdqepgptcTLSDCLRSFTDLEELDETELYFCHKCKKRQKSTKKFWVQKLPKVLCLHLKRFHW--TAFLRN 424
           **********7776655577899********************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           ki+++vefpl+ Ld++ ++ +pe++  e++ Y+L+avvvH+G +++sGHY+ay  + +g+W++f+Ds+Vt ++e+ v +   ++aY+lf
   Q: 425  KIDTYVEFPLKgLDMRGYLLEPENSLPESCVYDLVAVVVHHGsGVGSGHYTAYGSH-EGCWYHFNDSTVTLTNEDAVRK---AKAYILF 509
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 510  YVE 512
           *76 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MECFHLNSSV SCPIDSSRFP NGTPSSWCCS VCRSNKSPWI CLTCLMVHCG RYVNGHAKKH 60
FEETQAVGVS QRKSDKQDKE KYHHSVCMDC SSYSVFCYRC DDFVVNDTKL GQVQKVREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTT TTCATTTGAA CTCCAGCGTA AGCTGTCCTA TAGATTCCTC AAGGTTTCCT 60
AACGGTACTC CGTCCTCCTG GTGTTGCAGC GGTAAGGGAA AAATGATAAT TGTCACTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	78.69	0.00e+00	784.00
IUUC-Apl-003358	Anas platyrhynchos	78.41	0.00e+00	716.00
IUUC-Aca-004454	Anolis carolinensis	77.09	0.00e+00	694.00
IUUC-Ame-011544	Astyanax mexicanus	77.69	0.00e+00	765.00
IUUC-Bta-012738	Bos taurus	78.35	0.00e+00	742.00
IUUC-Cel-018186	Caenorhabditis elegans	35.99	5.00e-59	221.00
IUUC-Cja-018893	Callithrix jacchus	78.50	0.00e+00	749.00
IUUC-Cfa-020607	Canis familiaris	78.89	0.00e+00	748.00
IUUC-Cpo-021828	Cavia porcellus	78.69	0.00e+00	741.00
IUUC-Csa-023884	Chlorocebus sabaeus	80.90	2.00e-180	625.00
IUUC-Cho-024863	Choloepus hoffmanni	71.79	0.00e+00	654.00
IUUC-Dre-028452	Danio rerio	78.89	0.00e+00	808.00
IUUC-Dno-029531	Dasypus novemcinctus	78.62	0.00e+00	698.00
IUUC-Dor-030913	Dipodomys ordii	71.73	2.00e-139	488.00
IUUC-Ete-032611	Echinops telfairi	72.94	0.00e+00	698.00
IUUC-Eca-033622	Equus caballus	79.02	0.00e+00	703.00
IUUC-Eeu-035268	Erinaceus europaeus	75.31	0.00e+00	642.00
IUUC-Fca-035801	Felis catus	79.02	0.00e+00	721.00
IUUC-Fal-036749	Ficedula albicollis	78.25	0.00e+00	699.00
IUUC-Gmo-039598	Gadus morhua	82.42	0.00e+00	842.00
IUUC-Gga-040883	Gallus gallus	78.21	0.00e+00	696.00
IUUC-Gac-042235	Gasterosteus aculeatus	86.73	0.00e+00	889.00
IUUC-Ggo-044767	Gorilla gorilla	74.39	0.00e+00	658.00
IUUC-Hsa-046581	Homo sapiens	78.31	0.00e+00	764.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	78.12	0.00e+00	744.00
IUUC-Lch-049732	Latimeria chalumnae	78.65	0.00e+00	808.00
IUUC-Loc-052371	Lepisosteus oculatus	81.57	0.00e+00	824.00
IUUC-Laf-054565	Loxodonta africana	77.93	0.00e+00	743.00
IUUC-Mcc-055522	Macaca mulatta	78.50	0.00e+00	767.00
IUUC-Meu-056754	Macropus eugenii	68.58	1.00e-137	483.00
IUUC-Mga-060095	Meleagris gallopavo	75.22	9.00e-146	509.00
IUUC-Mmr-060839	Microcebus murinus	78.69	0.00e+00	749.00
IUUC-Mdo-062339	Monodelphis domestica	79.95	4.00e-178	617.00
IUUC-Mmu-063638	Mus musculus	77.54	0.00e+00	723.00
IUUC-Mpu-066647	Mustela putorius furo	81.11	5.00e-180	623.00
IUUC-Mlu-067921	Myotis lucifugus	77.80	0.00e+00	719.00
IUUC-Nle-069752	Nomascus leucogenys	78.69	0.00e+00	767.00
IUUC-Opr-070636	Ochotona princeps	68.71	2.00e-171	595.00
IUUC-Ont-071638	Oreochromis niloticus	89.68	0.00e+00	858.00
IUUC-Oan-073417	Ornithorhynchus anatinus	73.51	0.00e+00	702.00
IUUC-Ocu-074620	Oryctolagus cuniculus	78.50	0.00e+00	743.00
IUUC-Ola-087281	Oryzias latipes	88.86	0.00e+00	754.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.23	7.00e-56	210.00
IUUC-Oga-088448	Otolemur garnettii	78.69	0.00e+00	769.00
IUUC-Oar-090132	Ovis aries	78.69	0.00e+00	747.00
IUUC-Ptr-090696	Pan troglodytes	78.86	0.00e+00	721.00
IUUC-Pan-092124	Papio anubis	78.31	0.00e+00	763.00
IUUC-Psi-093801	Pelodiscus sinensis	79.49	6.00e-177	613.00
IUUC-Pma-094472	Petromyzon marinus	72.73	2.00e-93	334.00
IUUC-Pfo-096330	Poecilia formosa	87.88	0.00e+00	924.00
IUUC-Pab-098191	Pongo abelii	78.69	0.00e+00	768.00
IUUC-Pca-100341	Procavia capensis	75.98	7.00e-165	573.00
IUUC-Pva-103177	Pteropus vampyrus	78.46	0.00e+00	743.00
IUUC-Rno-105048	Rattus norvegicus	77.63	0.00e+00	716.00
IUUC-Sha-107429	Sarcophilus harrisii	77.51	0.00e+00	696.00
IUUC-Sar-113024	Sorex araneus	78.51	0.00e+00	657.00
IUUC-Ssc-115749	Sus scrofa	75.52	2.00e-121	428.00
IUUC-Tgu-117277	Taeniopygia guttata	78.00	0.00e+00	714.00
IUUC-Tsy-119456	Tarsius syrichta	76.53	0.00e+00	693.00
IUUC-Tni-120251	Tetraodon nigroviridis	91.38	0.00e+00	986.00
IUUC-Tbe-127423	Tupaia belangeri	73.90	0.00e+00	684.00
IUUC-Ttr-128401	Tursiops truncatus	72.65	1.00e-180	625.00
IUUC-Vpa-130549	Vicugna pacos	69.05	1.00e-127	449.00
IUUC-Xtr-131892	Xenopus tropicalis	71.40	0.00e+00	681.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence