iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131892

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01035294

Gene Name

usp3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009728.3	ENSXETT00000021444.3	ENSXETP00000021444.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-84	283.6	180	518
UBD/ZnF/ZnF_UBP	2.90e-26	91.6	26	105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 14   SvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqD 91
           S++  + ni+++ ++++e             +++ + +++ + + +l+++++k + +lw+++++a+sp++l+ +++k+ ++f+gy+qqD
   Q: 180  SLIKYINNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDVNVSLVEEFRKTLCALWQGNQTAFSPESLFYVVWKIMPNFRGYQQQD 268
           77888899**********887777666654444444555577778******************************************** PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
           a+Ef+++lld+l+ el+ e + + ++  +++++++s  +++   +  +++++ +F+g l++++ cl c+++s +++pfldlsl++p++ 
   Q: 269  AHEFMRYLLDHLHLELQGEFDGSSHSVLSQANCSRSA-SNKCCINGASTVVTSVFGGVLQNEVNCLICGTESRKFDPFLDLSLDIPSQF 356
           ****************765555555554444444444.4677889999**************************************655 PP
   S: 181  etkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.L 259
            +k           +l+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+k++++v+fpl+ L
   Q: 357  RNKRCknqengptcTLRDCLRSFTDLEELDETELYTCLKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRNKVDTYVDFPLRgL 443
           33322566789999****************************************************7755..799************** PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           d+++f+ +pe+   e++ Y+L avvvH+G +++sGHY+ay+ + kg+W++f+Ds+Vt ++ee+v +   ++aY+lfY +
   Q: 444  DMKSFLLEPENIGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-KGRWFHFNDSTVTLTEEETVAK---AKAYILFYVE 518
           *******************************************.**********************...********76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl..................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                  ++++s++s+ycY+cdd+v++
   Q: 26   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQAPLnchkrqektdkdrmqhtvCMDCSSYSTYCYRCDDFVVN 105
           9*****************************************************************************85 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MECPHLTTSV CMPDAAVFPN GCPSSWCCSV CRSNKSPWVC LTCSSVHCGR YVNGHAKKHY 60
EDAQAPLNCH KRQEKTDKDR MQHTVCMDCS SYSTYCYRCD DFVVNDTKLC LVQKVREHLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGCC CGCACCTGAC CACCAGTGTT TGTATGTCCC GGACGCCGCC GTTTTTCCCA 60
ACGGCTGTCC TTCCTCATGG TGTTGCAGCG GTGAGTCTGG CTCCTCCTCC CCGAACTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	82.80	0.00e+00	801.00
IUUC-Apl-003358	Anas platyrhynchos	83.17	0.00e+00	764.00
IUUC-Aca-004454	Anolis carolinensis	80.19	0.00e+00	712.00
IUUC-Ame-011544	Astyanax mexicanus	70.92	0.00e+00	663.00
IUUC-Bta-012738	Bos taurus	82.83	0.00e+00	781.00
IUUC-Cja-018893	Callithrix jacchus	82.61	0.00e+00	791.00
IUUC-Cfa-020607	Canis familiaris	83.18	0.00e+00	787.00
IUUC-Cpo-021828	Cavia porcellus	82.61	0.00e+00	777.00
IUUC-Csa-023884	Chlorocebus sabaeus	83.10	0.00e+00	647.00
IUUC-Cho-024863	Choloepus hoffmanni	78.26	0.00e+00	720.00
IUUC-Dre-028452	Danio rerio	69.74	0.00e+00	680.00
IUUC-Dno-029531	Dasypus novemcinctus	83.37	0.00e+00	738.00
IUUC-Dor-030913	Dipodomys ordii	73.47	2.00e-144	505.00
IUUC-Ete-032611	Echinops telfairi	78.64	0.00e+00	736.00
IUUC-Eca-033622	Equus caballus	83.37	0.00e+00	736.00
IUUC-Eeu-035268	Erinaceus europaeus	78.92	0.00e+00	667.00
IUUC-Fca-035801	Felis catus	83.57	0.00e+00	763.00
IUUC-Fal-036749	Ficedula albicollis	83.40	0.00e+00	737.00
IUUC-Gmo-039598	Gadus morhua	70.33	0.00e+00	697.00
IUUC-Gga-040883	Gallus gallus	83.37	0.00e+00	738.00
IUUC-Gac-042235	Gasterosteus aculeatus	69.38	0.00e+00	665.00
IUUC-Ggo-044767	Gorilla gorilla	78.20	0.00e+00	695.00
IUUC-Hsa-046581	Homo sapiens	82.80	0.00e+00	811.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	83.36	0.00e+00	787.00
IUUC-Lch-049732	Latimeria chalumnae	81.59	0.00e+00	816.00
IUUC-Loc-052371	Lepisosteus oculatus	79.43	0.00e+00	796.00
IUUC-Laf-054565	Loxodonta africana	83.18	0.00e+00	784.00
IUUC-Mcc-055522	Macaca mulatta	83.36	0.00e+00	816.00
IUUC-Meu-056754	Macropus eugenii	72.99	5.00e-146	510.00
IUUC-Mga-060095	Meleagris gallopavo	80.06	8.00e-155	539.00
IUUC-Mmr-060839	Microcebus murinus	83.18	0.00e+00	788.00
IUUC-Mdo-062339	Monodelphis domestica	84.62	0.00e+00	647.00
IUUC-Mmu-063638	Mus musculus	82.80	0.00e+00	763.00
IUUC-Mpu-066647	Mustela putorius furo	83.48	0.00e+00	641.00
IUUC-Mlu-067921	Myotis lucifugus	82.57	0.00e+00	755.00
IUUC-Nle-069752	Nomascus leucogenys	82.99	0.00e+00	813.00
IUUC-Opr-070636	Ochotona princeps	73.49	2.00e-175	608.00
IUUC-Ont-071638	Oreochromis niloticus	71.10	0.00e+00	639.00
IUUC-Oan-073417	Ornithorhynchus anatinus	77.88	0.00e+00	752.00
IUUC-Ocu-074620	Oryctolagus cuniculus	81.85	0.00e+00	778.00
IUUC-Ola-087281	Oryzias latipes	70.98	2.00e-160	558.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.00	3.00e-47	181.00
IUUC-Oga-088448	Otolemur garnettii	82.42	0.00e+00	808.00
IUUC-Oar-090132	Ovis aries	82.80	0.00e+00	785.00
IUUC-Ptr-090696	Pan troglodytes	83.20	0.00e+00	764.00
IUUC-Pan-092124	Papio anubis	83.18	0.00e+00	813.00
IUUC-Psi-093801	Pelodiscus sinensis	83.94	0.00e+00	642.00
IUUC-Pma-094300	Petromyzon marinus	71.86	2.00e-96	345.00
IUUC-Pfo-096330	Poecilia formosa	72.66	0.00e+00	717.00
IUUC-Pab-098191	Pongo abelii	83.18	0.00e+00	815.00
IUUC-Pca-100341	Procavia capensis	80.46	5.00e-173	600.00
IUUC-Pva-103177	Pteropus vampyrus	83.18	0.00e+00	782.00
IUUC-Rno-105048	Rattus norvegicus	80.91	0.00e+00	749.00
IUUC-Sha-107429	Sarcophilus harrisii	83.60	0.00e+00	743.00
IUUC-Sar-113024	Sorex araneus	81.80	0.00e+00	685.00
IUUC-Ssc-115749	Sus scrofa	78.12	2.00e-123	434.00
IUUC-Tgu-117277	Taeniopygia guttata	83.57	0.00e+00	764.00
IUUC-Tru-117844	Takifugu rubripes	71.40	0.00e+00	705.00
IUUC-Tsy-119456	Tarsius syrichta	80.92	0.00e+00	728.00
IUUC-Tni-120251	Tetraodon nigroviridis	68.70	0.00e+00	721.00
IUUC-Tme-126976	Tuber melanosporum	34.04	2.00e-41	163.00
IUUC-Tbe-127423	Tupaia belangeri	80.91	0.00e+00	753.00
IUUC-Ttr-128401	Tursiops truncatus	76.71	0.00e+00	652.00
IUUC-Vpa-130549	Vicugna pacos	70.55	2.00e-130	458.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence