iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140464.19	ENST00000395135.7	ENSP00000378567.3
ENSG00000140464.19	ENST00000395132.6	ENSP00000378564.2
ENSG00000140464.19	ENST00000268059.10	ENSP00000268059.6
ENSG00000140464.19	ENST00000354026.10	ENSP00000315434.8
ENSG00000140464.19	ENST00000268058.7	ENSP00000268058.3
ENSG00000140464.19	ENST00000565898.5	ENSP00000455838.1
ENSG00000140464.19	ENST00000569477.5	ENSP00000455612.1
ENSG00000140464.19	ENST00000569965.5	ENSP00000456486.1
ENSG00000140464.19	ENST00000567543.5	ENSP00000456277.1
ENSG00000140464.19	ENST00000435786.6	ENSP00000395576.2
ENSG00000140464.19	ENST00000564428.5	ENSP00000457023.1
ENSG00000140464.19	ENST00000563500.5	ENSP00000457032.1
ENSG00000140464.19	ENST00000565239.5	ENSP00000456989.1
ENSG00000140464.19	ENST00000567606.5	ENSP00000457669.1
ENSG00000140464.19	ENST00000566068.1	ENSP00000458061.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20130140

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	69.29	0.00e+00	1087.00	IUUC-Mmu-063118

Organism

Homo sapiens

Functional Description
(View)

Functional Description

Key component of PML bodies. PML bodies are formed by the interaction of PML homodimers (via SUMO-binding motif) with sumoylated PML, leading to the assembly of higher oligomers. Several types of PML bodies have been observed. PML bodies can form hollow spheres that can sequester target proteins inside. Interacts (via SUMO-binding motif) with sumoylated proteins. Interacts (via C-terminus) with p53/TP53. Recruits p53/TP53 and CHEK2 into PML bodies, which promotes p53/TP53 phosphorylation at 'Ser-20' and prevents its proteasomal degradation. Interacts with MDM2, and sequesters MDM2 in the nucleolus, thereby preventing ubiquitination of p53/TP53. Interaction with PML-RARA oncoprotein and certain viral proteins causes disassembly of PML bodies and abolishes the normal PML function. Interacts with HIPK2, TERT, SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with ELF4 (via C-terminus). Interacts with Lassa virus Z protein and rabies virus phosphoprotein. Interacts with ITPR3. Interacts (in the cytoplasm) with TGFBR1, TGFBR2 and PKM. Interacts (via the coiled-coil domain and when sumoylated) with SATB1. Interacts with UBE2I; the interaction is enhanced by arsenic binding. Interacts (PML-RARA oncoprotein, via the coiled-coil domain) with UBE2I; the interaction is enhanced by arsenic binding and is required for PML-RARA oncoprotein sumoylation and inhibition of RARA transactivational activity. Interacts with RB1, PPP1A, SMAD2, SMAD3, DAXX, RPL11 and MTOR. Interacts with PPARGC1A and KAT2A. Interacts with CSNK2A1 and CSNK2A3. Interacts with ANKRD2; the interaction is direct. Interacts (via SUMO-interacting motif) with sumoylated MORC3 (PubMed:20501696). Isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 interact with RNF4. Isoform PML-1 interacts with NLRP3. Isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5 interact with MAGEA2, RBL2, PER2 and E2F4. Isoform PML-2 interacts with CIITA. Isoform PML-2, isoform PML-3 and isoform PML-4 interact with TBX2. Isoform PML-4 interacts with RANBP2, HDAC7, KAT6A, WRN, PIN1, TBX3 and phosphorylated MAPK1/ERK2. Isoform PML-4 interacts with the CTNNB1 and TCF7L2/TCF4 complex. Isoform PML-4 preferentially interacts with MAPK7/BMK1 although other isoforms (isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6) also interact with it. Isoform PML-12 interacts with PIAS1, PIAS2 (isoform PIAS2-alpha) and CSNK2A1/CK2. Isoform PML-3 interacts with HFV bel1/tas and bet. Isoform PML-4 interacts with VZV capsid protein VP26/ORF23 capsid protein. Ths sumoylated isoform PML-4 interacts with encephalomyocarditis virus (EMCV) RNA-directed RNA polymerase 3D-POL (P3D-POL). Isoform PML-1 interacts with herpes simplex virus-1 (HHV-1) ICP0. Isoform PML-2 interacts with human adenovirus 2 E1A and this interaction stimulates E1A-dependent transcriptional activation (PubMed:23135708). Isoform PML-6 interacts with moloney murine leukemia virus (MoMLV) integrase (IN) and reverse transcriptase (RT). Isoform PML-4 and isoform PML-5 interact with human adenovirus 5 E1B-55K protein; these interactions promote efficient subnuclear targeting of E1B-55K to PML nuclear bodies (PubMed:20639899, PubMed:25772236).

Protein Sequence
(Fasta)

MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC 60
QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR 120

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Nucleotide Sequence
(Fasta)

CTCTCCAGAG GCGGGCCCTG AGCCGGCACC TCCCCTTTCG GACAGCTCAA GGGACTCAGC 60
CAACTGGCTC ACGCCTCCCC TTCAGCTTCT CTTCACGCAC TCCAAGATCT AAACCGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0053--Apoptosis
KW-0090--Biological rhythms
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021978--DUF3583
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12126--DUF3583
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050897--F:cobalt ion binding
GO:0003677--F:DNA binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0032183--F:SUMO binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007050--P:cell cycle arrest
GO:0045165--P:cell fate commitment
GO:0071353--P:cellular response to interleukin-4
GO:0090398--P:cellular senescence
GO:0032922--P:circadian regulation of gene expression
GO:0007182--P:common-partner SMAD protein phosphorylation
GO:0051607--P:defense response to virus
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0010761--P:fibroblast migration
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0051457--P:maintenance of protein location in nucleus
GO:0030099--P:myeloid cell differentiation
GO:0016525--P:negative regulation of angiogenesis
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:0045930--P:negative regulation of mitotic cell cycle
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0032938--P:negative regulation of translation in response to oxidative stress
GO:1902187--P:negative regulation of viral release from host cell
GO:0030578--P:PML body organization
GO:0060058--P:positive regulation of apoptotic process involved in mammary gland involution
GO:0002230--P:positive regulation of defense response to virus by host
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045345--P:positive regulation of MHC class I biosynthetic process
GO:1904816--P:positive regulation of protein localization to chromosome, telomeric region
GO:0032206--P:positive regulation of telomere maintenance
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization
GO:0006605--P:protein targeting
GO:0010522--P:regulation of calcium ion transport into cytosol
GO:0030155--P:regulation of cell adhesion
GO:0042752--P:regulation of circadian rhythm
GO:2000779--P:regulation of double-strand break repair
GO:0001932--P:regulation of protein phosphorylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006355--P:regulation of transcription, DNA-templated
GO:0034097--P:response to cytokine
GO:0010332--P:response to gamma radiation
GO:0001666--P:response to hypoxia
GO:0009411--P:response to UV
GO:0048384--P:retinoic acid receptor signaling pathway
GO:0007184--P:SMAD protein import into nucleus
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway

KEGG

hsa:5371

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001901	Ailuropoda melanoleuca	79.71	0.00e+00	1242.00
IUUC-Bta-012427	Bos taurus	75.37	0.00e+00	1239.00
IUUC-Cja-019029	Callithrix jacchus	92.85	0.00e+00	1480.00
IUUC-Cfa-021127	Canis familiaris	78.05	0.00e+00	1231.00
IUUC-Cpo-022553	Cavia porcellus	71.45	0.00e+00	1077.00
IUUC-Csa-023187	Chlorocebus sabaeus	94.93	0.00e+00	1056.00
IUUC-Cho-024937	Choloepus hoffmanni	72.61	1.00e-106	380.00
IUUC-Dno-029326	Dasypus novemcinctus	78.02	0.00e+00	1187.00
IUUC-Dor-030808	Dipodomys ordii	63.68	0.00e+00	754.00
IUUC-Ete-032746	Echinops telfairi	57.42	0.00e+00	635.00
IUUC-Eca-033234	Equus caballus	80.93	0.00e+00	1222.00
IUUC-Fca-035648	Felis catus	82.29	0.00e+00	1311.00
IUUC-Ggo-044927	Gorilla gorilla	99.77	0.00e+00	1652.00
IUUC-Itr-047861	Ictidomys tridecemlineatus	82.84	0.00e+00	1364.00
IUUC-Loc-052276	Lepisosteus oculatus	35.22	2.00e-53	204.00
IUUC-Laf-054059	Loxodonta africana	76.75	0.00e+00	1202.00
IUUC-Meu-056495	Macropus eugenii	55.41	1.00e-107	384.00
IUUC-Mga-059224	Meleagris gallopavo	32.85	4.00e-84	306.00
IUUC-Mmr-061507	Microcebus murinus	80.05	0.00e+00	1273.00
IUUC-Mdo-062196	Monodelphis domestica	46.78	0.00e+00	662.00
IUUC-Mmu-063118	Mus musculus	69.29	0.00e+00	1131.00
IUUC-Mpu-066024	Mustela putorius furo	73.89	0.00e+00	1161.00
IUUC-Mlu-066980	Myotis lucifugus	78.65	0.00e+00	1201.00
IUUC-Nle-069779	Nomascus leucogenys	97.73	0.00e+00	1536.00
IUUC-Ocu-074016	Oryctolagus cuniculus	65.91	0.00e+00	1043.00
IUUC-Oga-089085	Otolemur garnettii	71.44	0.00e+00	1125.00
IUUC-Oar-089980	Ovis aries	72.99	0.00e+00	1172.00
IUUC-Ptr-091681	Pan troglodytes	99.66	0.00e+00	1650.00
IUUC-Pan-091965	Papio anubis	94.56	0.00e+00	1494.00
IUUC-Psi-093577	Pelodiscus sinensis	37.88	4.00e-126	445.00
IUUC-Pab-098215	Pongo abelii	85.75	0.00e+00	1367.00
IUUC-Pca-100883	Procavia capensis	72.50	0.00e+00	858.00
IUUC-Pva-102465	Pteropus vampyrus	74.31	0.00e+00	822.00
IUUC-Rno-105120	Rattus norvegicus	69.06	0.00e+00	1167.00
IUUC-Sar-113320	Sorex araneus	62.21	1.00e-91	331.00
IUUC-Ssc-116042	Sus scrofa	76.92	0.00e+00	1239.00
IUUC-Tbe-127880	Tupaia belangeri	69.14	0.00e+00	903.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence