iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000140600.16	ENST00000427482.6	ENSP00000391372.2
ENSG00000140600.16	ENST00000563901.5	ENSP00000456249.1
ENSG00000140600.16	ENST00000324537.5	ENSP00000320092.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-13	51.5	297	350

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            ++ lyd+e++n++eL +k+Gd++++   ++ de+W +g    +g +G+fP n+ve +
   Q: 297  CCRGLYDFEPENQGELGFKEGDIITLT--NQIDENWYEG--MIHGESGFFPINYVEVI 350
           5889**********************7..99********..8*************976 PP

Organism

Homo sapiens

Functional Description
(View)

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).

Protein Sequence
(Fasta)

MDGIFAGIIC NQANRCLTWT SQQLFSEKIS GAEGTKLDDE FLDMERKIDV TNKVVAEILS 60
KTTEYLQPNP AYRAKLGMLN TVSKIRGQVK TTGYPQTEGL LGDCMLKYGK ELGEDSTFGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCTCAAG TAGCCCAGGT CTCCACGCAA CAATGAAGCG TGGGCGGCCC CAGCAGCTTC 60
ATTTGCATAT CGCCGCGGCT TGGCCAATGG GCTGCGCAGG GGCTTTGGAA CGCAGTGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR028501--Endophilin-A
IPR032469--Endophilin-A3_BAR
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50002--SH3

Pfam

PF03114--BAR
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00721--BAR
SM00326--SH3

Gene Ontology

GO:0031901--C:early endosome membrane
GO:0070062--C:extracellular exosome
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0007417--P:central nervous system development
GO:0006897--P:endocytosis
GO:0007165--P:signal transduction

KEGG

hsa:6457

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001598	Ailuropoda melanoleuca	84.51	3.00e-173	600.00
IUUC-Apl-003422	Anas platyrhynchos	82.25	1.00e-157	549.00
IUUC-Ame-010779	Astyanax mexicanus	72.51	3.00e-152	531.00
IUUC-Bta-012748	Bos taurus	94.59	0.00e+00	635.00
IUUC-Cja-019400	Callithrix jacchus	97.61	0.00e+00	655.00
IUUC-Cfa-020979	Canis familiaris	91.67	1.00e-174	605.00
IUUC-Cpo-021364	Cavia porcellus	95.20	0.00e+00	630.00
IUUC-Csa-023447	Chlorocebus sabaeus	98.51	0.00e+00	630.00
IUUC-Cho-024825	Choloepus hoffmanni	78.61	1.00e-145	509.00
IUUC-Dre-028063	Danio rerio	75.59	2.00e-154	538.00
IUUC-Dno-029219	Dasypus novemcinctus	88.36	2.00e-167	581.00
IUUC-Dse-031165	Dothistroma septosporum	41.54	5.00e-12	67.40
IUUC-Dme-031633	Drosophila melanogaster	48.93	9.00e-97	347.00
IUUC-Ete-033094	Echinops telfairi	78.25	4.00e-147	514.00
IUUC-Eca-033209	Equus caballus	92.84	2.00e-180	625.00
IUUC-Fca-036354	Felis catus	85.71	1.00e-175	608.00
IUUC-Fal-037519	Ficedula albicollis	81.76	8.00e-147	513.00
IUUC-Gmo-038787	Gadus morhua	72.40	1.00e-146	512.00
IUUC-Gga-041064	Gallus gallus	81.52	1.00e-157	549.00
IUUC-Gac-042091	Gasterosteus aculeatus	73.59	4.00e-150	524.00
IUUC-Ggo-045608	Gorilla gorilla	79.29	6.00e-141	493.00
IUUC-Itr-048671	Ictidomys tridecemlineatus	94.93	0.00e+00	635.00
IUUC-Lch-050556	Latimeria chalumnae	68.83	1.00e-151	529.00
IUUC-Loc-052711	Lepisosteus oculatus	73.10	1.00e-158	552.00
IUUC-Laf-054427	Loxodonta africana	91.29	4.00e-168	583.00
IUUC-Mcc-055620	Macaca mulatta	98.21	0.00e+00	629.00
IUUC-Mor-056932	Magnaporthe oryzae	34.62	8.00e-13	70.10
IUUC-Mga-059193	Meleagris gallopavo	78.47	6.00e-156	543.00
IUUC-Mmr-060860	Microcebus murinus	79.33	2.00e-156	545.00
IUUC-Mmu-064365	Mus musculus	85.63	1.00e-168	585.00
IUUC-Mpu-066396	Mustela putorius furo	94.03	0.00e+00	636.00
IUUC-Nle-069316	Nomascus leucogenys	98.59	0.00e+00	701.00
IUUC-Opr-070964	Ochotona princeps	90.96	2.00e-174	604.00
IUUC-Ont-071397	Oreochromis niloticus	69.92	7.00e-149	520.00
IUUC-Oar-089220	Ovis aries	93.99	0.00e+00	628.00
IUUC-Ptr-090984	Pan troglodytes	99.72	0.00e+00	710.00
IUUC-Pan-092153	Papio anubis	98.51	0.00e+00	630.00
IUUC-Psi-093559	Pelodiscus sinensis	82.46	7.00e-161	560.00
IUUC-Pab-098780	Pongo abelii	84.34	3.00e-152	530.00
IUUC-Pva-103165	Pteropus vampyrus	76.20	4.00e-136	477.00
IUUC-Rno-104935	Rattus norvegicus	85.67	2.00e-169	587.00
IUUC-Sja-107704	Schizosaccharomyces japonicus	24.93	1.00e-11	64.70
IUUC-Spo-108224	Schizosaccharomyces pombe	26.70	2.00e-24	107.00
IUUC-Tsy-119366	Tarsius syrichta	94.94	0.00e+00	669.00
IUUC-Tbe-127252	Tupaia belangeri	75.73	1.00e-132	465.00
IUUC-Ttr-128272	Tursiops truncatus	86.88	5.00e-156	543.00
IUUC-Xtr-131882	Xenopus tropicalis	72.55	2.00e-152	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence