iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141552.17	ENST00000571570.5	ENSP00000458143.1
ENSG00000141552.17	ENST00000582222.5	ENSP00000464403.1
ENSG00000141552.17	ENST00000357385.7	ENSP00000349957.3
ENSG00000141552.17	ENST00000584197.5	ENSP00000464519.1
ENSG00000141552.17	ENST00000585259.1	ENSP00000462527.1
ENSG00000141552.17	ENST00000612413.4	ENSP00000484031.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	19690564; 21107322; 16763193

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0026	19.9	23	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+  f            +++++ ++C H+fh +C+ kw    + ++ +++CP Cr
   Q: 23   CGICRMAFngccpdckvpgdDCPLVWGQCSHCFHMHCILKW---LHAQQVQQHCPMCR 77
           9999666688788888888666677799*************...445999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Protein Sequence
(Fasta)

MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI 60
LKWLHAQQVQ QHCPMCRQEW KFKE 84

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGCTGCCA CTTGTCGGGA AGTTGTTTTG GCTGAAAAAA AAACCGCAAC AAGAGCAGAT 60
CTGTGAGTCT CAGTCCAGGG CTTTCCTGAC CCTCACGGCT ACTCCGGACC CTTCCTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF12861--zf-ANAPC11

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0097602--F:cullin family protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:51529

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002323	Ailuropoda melanoleuca	98.81	5.00e-45	171.00
IUUC-Aly-006393	Arabidopsis lyrata	68.29	5.00e-33	131.00
IUUC-Ath-006698	Arabidopsis thaliana	68.29	5.00e-33	131.00
IUUC-Ago-007824	Ashbya gossypii	42.42	6.00e-19	86.30
IUUC-Acl-008180	Aspergillus clavatus	57.50	6.00e-24	102.00
IUUC-Afl-008622	Aspergillus flavus	57.50	4.00e-24	102.00
IUUC-Afu-008844	Aspergillus fumigatus	56.25	2.00e-23	100.00
IUUC-Ani-009260	Aspergillus nidulans	56.25	1.00e-23	100.00
IUUC-Ang-009794	Aspergillus niger	58.23	2.00e-27	117.00
IUUC-Ame-011274	Astyanax mexicanus	91.67	1.00e-38	150.00
IUUC-Bgr-012017	Blumeria graminis	50.63	1.00e-18	84.00
IUUC-Bta-012644	Bos taurus	97.62	7.00e-45	171.00
IUUC-Bci-013779	Botrytis cinerea	52.94	1.00e-23	100.00
IUUC-Bdi-014975	Brachypodium distachyon	67.47	1.00e-31	127.00
IUUC-Bol-016184	Brassica oleracea	70.13	1.00e-31	127.00
IUUC-Bra-016983	Brassica rapa	65.48	3.00e-33	133.00
IUUC-Cel-018191	Caenorhabditis elegans	48.28	3.00e-18	83.60
IUUC-Cja-019909	Callithrix jacchus	100.00	1.00e-45	173.00
IUUC-Cfa-020306	Canis familiaris	98.81	5.00e-45	171.00
IUUC-Cpo-021773	Cavia porcellus	98.81	5.00e-45	171.00
IUUC-Cre-022961	Chlamydomonas reinhardtii	54.76	5.00e-24	102.00
IUUC-Csa-024274	Chlorocebus sabaeus	100.00	1.00e-45	173.00
IUUC-Cgl-026398	Colletotrichum gloeosporioides	53.57	3.00e-23	99.00
IUUC-Cne-027036	Cryptococcus neoformans	45.19	3.00e-22	96.70
IUUC-Cme-027263	Cyanidioschyzon merolae	55.95	2.00e-26	110.00
IUUC-Dre-027617	Danio rerio	91.67	5.00e-39	151.00
IUUC-Dse-031304	Dothistroma septosporum	58.02	9.00e-24	101.00
IUUC-Dme-031897	Drosophila melanogaster	72.29	4.00e-34	135.00
IUUC-Fca-036297	Felis catus	98.81	7.00e-46	174.00
IUUC-Fal-037228	Ficedula albicollis	88.10	2.00e-42	162.00
IUUC-Fox-037929	Fusarium oxysporum	60.34	1.00e-15	74.30
IUUC-Fso-038194	Fusarium solani	56.96	4.00e-22	95.50
IUUC-Gmo-039638	Gadus morhua	93.62	1.00e-18	84.00
IUUC-Gga-040897	Gallus gallus	91.67	1.00e-43	166.00
IUUC-Gac-041644	Gasterosteus aculeatus	93.62	1.00e-18	84.00
IUUC-Gma-043111	Glycine max	67.07	1.00e-32	131.00
IUUC-Hvu-047356	Hordeum vulgare	66.27	4.00e-31	125.00
IUUC-Itr-048453	Ictidomys tridecemlineatus	98.81	5.00e-45	171.00
IUUC-Kpa-049388	Komagataella pastoris	42.20	2.00e-18	84.30
IUUC-Lch-049838	Latimeria chalumnae	90.48	3.00e-42	162.00
IUUC-Lpe-050878	Leersia perrieri	73.02	1.00e-25	107.00
IUUC-Lma-053166	Leptosphaeria maculans	53.57	5.00e-24	102.00
IUUC-Laf-054221	Loxodonta africana	98.81	5.00e-45	171.00
IUUC-Mor-056930	Magnaporthe oryzae	56.47	2.00e-24	103.00
IUUC-Mtr-058104	Medicago truncatula	71.05	7.00e-32	128.00
IUUC-Mla-059079	Melampsora laricipopulina	47.66	4.00e-24	103.00
IUUC-Mvi-060446	Microbotryum violaceum	65.52	4.00e-22	97.40
IUUC-Mmu-064301	Mus musculus	98.81	5.00e-45	171.00
IUUC-Mac-064936	Musa acuminata	71.08	1.00e-33	134.00
IUUC-Mpu-066041	Mustela putorius furo	98.81	5.00e-45	171.00
IUUC-Mlu-067360	Myotis lucifugus	97.62	7.00e-45	171.00
IUUC-Ncr-068931	Neurospora crassa	56.10	1.00e-23	101.00
IUUC-Ont-072502	Oreochromis niloticus	92.77	7.00e-39	151.00
IUUC-Ocu-074751	Oryctolagus cuniculus	88.10	5.00e-40	155.00
IUUC-Oba-075026	Oryza barthii	69.88	2.00e-32	130.00
IUUC-Obr-076888	Oryza brachyantha	68.67	3.00e-32	130.00
IUUC-Ogl-077846	Oryza glaberrima	69.88	2.00e-32	129.00
IUUC-Ogu-078433	Oryza glumaepatula	68.67	6.00e-33	133.00
IUUC-Oin-079264	Oryza indica	69.88	2.00e-32	129.00
IUUC-Ome-081297	Oryza meridionalis	74.60	3.00e-26	111.00
IUUC-Oni-082739	Oryza nivara	69.88	5.00e-33	133.00
IUUC-Opu-083502	Oryza punctata	74.60	2.00e-25	107.00
IUUC-Oru-084838	Oryza rufipogon	69.88	7.00e-33	132.00
IUUC-Osa-085826	Oryza sativa	69.88	2.00e-32	129.00
IUUC-Ola-087572	Oryzias latipes	92.86	6.00e-39	151.00
IUUC-Olu-087765	Ostreococcus lucimarinus	52.94	1.00e-23	100.00
IUUC-Oga-088853	Otolemur garnettii	98.81	3.00e-45	172.00
IUUC-Oar-089687	Ovis aries	98.81	5.00e-45	171.00
IUUC-Ptr-091674	Pan troglodytes	100.00	1.00e-45	173.00
IUUC-Psi-093124	Pelodiscus sinensis	95.24	6.00e-44	167.00
IUUC-Pno-094852	Phaeosphaeria nodorum	53.57	7.00e-24	102.00
IUUC-Ppa-095866	Physcomitrella patens	65.79	2.00e-29	119.00
IUUC-Pfo-096410	Poecilia formosa	90.48	3.00e-38	149.00
IUUC-Pop-099204	Populus trichocarpa	71.43	1.00e-32	130.00
IUUC-Ppe-101903	Prunus persica	68.67	2.00e-32	129.00
IUUC-Pte-104160	Pyrenophora teres	52.38	6.00e-23	98.60
IUUC-Rno-104979	Rattus norvegicus	98.81	5.00e-45	171.00
IUUC-Sce-106149	Saccharomyces cerevisiae	44.12	4.00e-19	87.40
IUUC-Sja-107930	Schizosaccharomyces japonicus	52.94	5.00e-24	101.00
IUUC-Spo-108296	Schizosaccharomyces pombe	53.09	7.00e-22	94.70
IUUC-Ssl-108464	Sclerotinia sclerotiorum	47.50	5.00e-15	72.00
IUUC-Smo-109289	Selaginella moellendorffii	65.79	1.00e-29	120.00
IUUC-Sit-109777	Setaria italica	67.47	1.00e-31	127.00
IUUC-Sly-111381	Solanum lycopersicum	74.36	5.00e-14	68.90
IUUC-Stu-112287	Solanum tuberosum	70.13	2.00e-32	130.00
IUUC-Sbi-113803	Sorghum bicolor	67.47	1.00e-31	127.00
IUUC-Sre-115018	Sporisorium reilianum	55.81	4.00e-22	95.50
IUUC-Ssc-116403	Sus scrofa	95.18	7.00e-43	164.00
IUUC-Tgu-117375	Taeniopygia guttata	88.10	2.00e-42	162.00
IUUC-Tru-118064	Takifugu rubripes	90.00	8.00e-36	140.00
IUUC-Tni-120387	Tetraodon nigroviridis	90.48	2.00e-38	149.00
IUUC-Tca-121186	Theobroma cacao	71.43	3.00e-22	96.30
IUUC-Tre-122153	Trichoderma reesei	56.25	2.00e-23	100.00
IUUC-Tvi-122412	Trichoderma virens	52.94	2.00e-23	100.00
IUUC-Tae-125184	Triticum aestivum	67.47	1.00e-31	127.00
IUUC-Tur-126516	Triticum urartu	66.27	1.00e-31	127.00
IUUC-Tme-127121	Tuber melanosporum	53.01	2.00e-24	103.00
IUUC-Uma-129529	Ustilago maydis	57.32	2.00e-21	93.60
IUUC-Vvi-131191	Vitis vinifera	71.05	3.00e-32	130.00
IUUC-Xma-133275	Xiphophorus maculatus	89.29	9.00e-38	147.00
IUUC-Yli-134369	Yarrowia lipolytica	60.98	6.00e-26	108.00
IUUC-Zma-134869	Zea mays	67.47	2.00e-31	126.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence