iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141569.10	ENST00000591668.5	ENSP00000465034.1
ENSG00000141569.10	ENST00000592642.1	ENSP00000466353.1
ENSG00000141569.10	ENST00000269383.7	ENSP00000269383.3
ENSG00000141569.10	ENST00000543309.5	ENSP00000441480.1
ENSG00000141569.10	ENST00000540128.1	ENSP00000444607.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19690564

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.50e-08	34.0	8	56
E3 activity/RING/RING	1.60e-05	27.0	12	51

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplte 52
           e + C+I l l +dPv+lp+G+ +  ++I+ w +++gk cP +r+p+ +
   Q: 8    EKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPD 56
           5789******************************************954 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl  ++d p++lpCgH f+  C+  w       ++++ CP Cr
   Q: 12   CAICLGLYQD-PVTLPCGHNFCGACIRDW----WDRCGKA-CPECR 51
           **********.9**************888....5556665.****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC REPFPDGAEL 60
RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR PLELFCRTEG RCVCSVCTVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCGCGAG GCCCGCGGTC CCTTTAAGAC GCCCGGGGCC CGCCTGGCTC TCGCCGCCGC 60
CGGGCCATGG CCGCGCAGCT GCTGGAGGAG AAGCTGACCT GCGCCATCTG CCTGGGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF00097--zf-C3HC4

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0010508--P:positive regulation of autophagy

KEGG

hsa:201292

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002422	Ailuropoda melanoleuca	75.94	2.00e-150	525.00
IUUC-Atr-002992	Amborella trichopoda	36.76	8.00e-11	61.20
IUUC-Apl-003984	Anas platyrhynchos	43.36	1.00e-17	81.60
IUUC-Ame-011110	Astyanax mexicanus	30.90	3.00e-52	199.00
IUUC-Bta-012830	Bos taurus	75.15	0.00e+00	632.00
IUUC-Bol-016180	Brassica oleracea	38.24	1.00e-11	63.90
IUUC-Bra-017905	Brassica rapa	38.24	1.00e-11	63.90
IUUC-Cja-019398	Callithrix jacchus	90.80	2.00e-128	451.00
IUUC-Cfa-021033	Canis familiaris	75.24	1.00e-149	523.00
IUUC-Cpo-021359	Cavia porcellus	69.83	1.00e-170	592.00
IUUC-Csa-023706	Chlorocebus sabaeus	93.04	0.00e+00	866.00
IUUC-Dre-027965	Danio rerio	30.77	1.00e-55	210.00
IUUC-Dno-029551	Dasypus novemcinctus	57.88	5.00e-153	535.00
IUUC-Dor-030830	Dipodomys ordii	67.06	5.00e-145	507.00
IUUC-Eca-033217	Equus caballus	74.73	1.00e-131	462.00
IUUC-Fca-036403	Felis catus	75.05	0.00e+00	673.00
IUUC-Fal-037118	Ficedula albicollis	41.47	7.00e-91	328.00
IUUC-Gmo-039107	Gadus morhua	31.95	6.00e-54	205.00
IUUC-Gac-042501	Gasterosteus aculeatus	33.40	2.00e-55	209.00
IUUC-Ggo-044481	Gorilla gorilla	89.96	0.00e+00	850.00
IUUC-Itr-049000	Ictidomys tridecemlineatus	66.60	3.00e-161	561.00
IUUC-Lch-050645	Latimeria chalumnae	31.43	1.00e-27	117.00
IUUC-Loc-052279	Lepisosteus oculatus	32.16	2.00e-56	213.00
IUUC-Laf-054143	Loxodonta africana	72.23	5.00e-173	600.00
IUUC-Mcc-055216	Macaca mulatta	91.68	0.00e+00	837.00
IUUC-Meu-056384	Macropus eugenii	65.22	1.00e-72	267.00
IUUC-Mtr-058007	Medicago truncatula	42.65	2.00e-13	70.10
IUUC-Mmr-061758	Microcebus murinus	82.84	0.00e+00	669.00
IUUC-Mdo-062422	Monodelphis domestica	47.49	4.00e-71	261.00
IUUC-Mmu-063753	Mus musculus	64.29	4.00e-162	564.00
IUUC-Mpu-065880	Mustela putorius furo	72.82	2.00e-173	602.00
IUUC-Mlu-067629	Myotis lucifugus	68.94	7.00e-88	317.00
IUUC-Nle-069604	Nomascus leucogenys	93.16	1.00e-171	595.00
IUUC-Opr-070884	Ochotona princeps	65.69	3.00e-169	588.00
IUUC-Oan-073697	Ornithorhynchus anatinus	55.11	2.00e-48	184.00
IUUC-Ocu-073936	Oryctolagus cuniculus	66.92	2.00e-170	592.00
IUUC-Ogu-078203	Oryza glumaepatula	38.24	3.00e-11	62.80
IUUC-Opu-083547	Oryza punctata	38.03	3.00e-11	62.80
IUUC-Oga-087916	Otolemur garnettii	79.44	2.00e-163	568.00
IUUC-Oar-090188	Ovis aries	75.24	1.00e-167	583.00
IUUC-Ptr-091364	Pan troglodytes	98.85	0.00e+00	634.00
IUUC-Pan-092240	Papio anubis	91.30	0.00e+00	885.00
IUUC-Psi-093439	Pelodiscus sinensis	45.89	9.00e-49	186.00
IUUC-Ppa-095897	Physcomitrella patens	46.81	2.00e-09	57.00
IUUC-Pfo-097460	Poecilia formosa	32.04	3.00e-55	209.00
IUUC-Pab-098661	Pongo abelii	88.01	0.00e+00	771.00
IUUC-Pop-099737	Populus trichocarpa	39.71	7.00e-11	63.20
IUUC-Pva-102208	Pteropus vampyrus	75.34	0.00e+00	647.00
IUUC-Rno-105456	Rattus norvegicus	63.53	2.00e-154	539.00
IUUC-Sha-107040	Sarcophilus harrisii	53.36	4.00e-121	428.00
IUUC-Sly-110934	Solanum lycopersicum	43.48	4.00e-14	72.40
IUUC-Sar-113700	Sorex araneus	68.36	4.00e-66	245.00
IUUC-Ssc-115895	Sus scrofa	74.95	0.00e+00	657.00
IUUC-Tru-118244	Takifugu rubripes	29.25	2.00e-48	186.00
IUUC-Tca-121416	Theobroma cacao	41.18	2.00e-13	69.70
IUUC-Tur-126688	Triticum urartu	38.24	6.00e-11	61.60
IUUC-Tbe-127865	Tupaia belangeri	71.17	6.00e-91	327.00
IUUC-Ttr-128578	Tursiops truncatus	76.31	0.00e+00	628.00
IUUC-Vvi-131424	Vitis vinifera	41.18	2.00e-12	67.00
IUUC-Xtr-131897	Xenopus tropicalis	34.71	2.00e-73	269.00
IUUC-Xma-133452	Xiphophorus maculatus	32.16	9.00e-55	207.00
IUUC-Zma-135432	Zea mays	53.19	3.00e-11	63.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence